ID   CATB_MACFA              Reviewed;         339 AA.
AC   Q4R5M2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Cathepsin B;
DE            EC=3.4.22.1;
DE   Contains:
DE     RecName: Full=Cathepsin B light chain;
DE   Contains:
DE     RecName: Full=Cathepsin B heavy chain;
DE   Flags: Precursor;
GN   Name=CTSB; ORFNames=QccE-13673;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thiol protease which is believed to participate in
CC       intracellular degradation and turnover of proteins. Has also been
CC       implicated in tumor invasion and metastasis (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of proteins with broad specificity
CC       for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in
CC       small molecule substrates (thus differing from cathepsin L). In
CC       addition to being an endopeptidase, shows peptidyl-dipeptidase
CC       activity, liberating C-terminal dipeptides.
CC   -!- SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by
CC       a disulfide bond (By similarity).
CC   -!- SUBCELLULAR LOCATION: Lysosome (By similarity). Melanosome (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the peptidase C1 family.
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DR   EMBL; AB169521; BAE01603.1; -; mRNA.
DR   SMR; Q4R5M2; 18-333.
DR   MEROPS; C01.060; -.
DR   HOVERGEN; Q4R5M2; -.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0050790; P:regulation of catalytic activity; IEA:InterPro.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR013128; Peptidase_C1A.
DR   InterPro; IPR000668; Peptidase_C1A_C.
DR   InterPro; IPR015643; Peptidase_C1A_cathepsin-B.
DR   InterPro; IPR012599; Propeptide_C1A.
DR   PANTHER; PTHR12411:SF16; CathepsinB_like; 1.
DR   PANTHER; PTHR12411; Peptidase_C1A; 1.
DR   Pfam; PF00112; Peptidase_C1; 1.
DR   Pfam; PF08127; Propeptide_C1; 1.
DR   PRINTS; PR00705; PAPAIN.
DR   ProDom; PD000158; Peptidase_C1; 1.
DR   SMART; SM00645; Pept_C1; 1.
DR   PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR   PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Signal;
KW   Thiol protease; Zymogen.
FT   SIGNAL        1     17       Potential.
FT   PROPEP       18     79       Activation peptide (By similarity).
FT                                /FTId=PRO_0000330875.
FT   CHAIN        80    333       Cathepsin B.
FT                                /FTId=PRO_0000330876.
FT   CHAIN        80    126       Cathepsin B light chain (By similarity).
FT                                /FTId=PRO_0000330877.
FT   CHAIN       129    333       Cathepsin B heavy chain (By similarity).
FT                                /FTId=PRO_0000330878.
FT   PROPEP      334    339       By similarity.
FT                                /FTId=PRO_0000330879.
FT   ACT_SITE    108    108       By similarity.
FT   ACT_SITE    278    278       By similarity.
FT   ACT_SITE    298    298       By similarity.
FT   CARBOHYD    192    192       N-linked (GlcNAc...) (Potential).
FT   DISULFID     93    122       By similarity.
FT   DISULFID    105    150       By similarity.
FT   DISULFID    141    207       By similarity.
FT   DISULFID    142    146       By similarity.
FT   DISULFID    179    211       By similarity.
FT   DISULFID    187    198       By similarity.
SQ   SEQUENCE   339 AA;  37776 MW;  57D18B0CE1CD56CF CRC64;
     MWWLWASLCC LLALGDARSR PSFHPLSDEL VNYVNKQNTT WQAGHNFYNV DVSYLKRLCG
     TFLGGPKPPQ RVMFTEDLKL PESFDAREQW PQCPTIKEIR DQGSCGSCWA FGAVEAISDR
     ICIHTNAHVS VEVSAEDLLT CCGIMCGDGC NGGYPAGAWN FWTRKGLVSG GLYDSHVGCR
     PYSIPPCEHH VNGSRPPCTG EGDTPKCSKI CEPGYSPTYK QDKHYGYNSY SVSNSEKDIM
     AEIYKNGPVE GAFSVYSDFL LYKSGVYQHV TGEMMGGHAI RILGWGVENG TPYWLVANSW
     NTDWGDNGFF KILRGQDHCG IESEVVAGIP RTDQYWEKI
//