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Protein

Maspardin

Gene

SPG21

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as a negative regulatory factor in CD4-dependent T-cell activation.By similarity

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

ESTHERimacfa-SPG21. Maspardin-ACP33-SPG21_like.

Names & Taxonomyi

Protein namesi
Recommended name:
Maspardin
Alternative name(s):
Spastic paraplegia 21 autosomal recessive Mast syndrome protein homolog
Gene namesi
Name:SPG21
ORF Names:QflA-14453
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308MaspardinPRO_0000227981Add
BLAST

Proteomic databases

PRIDEiQ4R5H6.

Interactioni

Subunit structurei

Interacts with CD4. Interacts with ALDH16A1.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ4R5H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily.Curated

Phylogenomic databases

HOVERGENiHBG080704.
KOiK19367.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR026151. Maspardin.
[Graphical view]
PANTHERiPTHR15913. PTHR15913. 1 hit.
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4R5H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEVKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP
60 70 80 90 100
PVSGTADVFF RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL
110 120 130 140 150
DKVHLFGASL GGFLAQKFAE YTHKSPRVHS LILCNSFSDT SIFNQTWTAN
160 170 180 190 200
SFWLMPAFML KKIVLGNFSS GPVDPMMADA IDFMVDRLES LGQSELASRL
210 220 230 240 250
TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK LYPNARRAHL
260 270 280 290 300
KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS

LGINQEEQ
Length:308
Mass (Da):34,973
Last modified:July 19, 2005 - v1
Checksum:i3BDD0A07F89981C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169567 mRNA. Translation: BAE01649.1.
RefSeqiNP_001270552.1. NM_001283623.1.
UniGeneiMfa.8304.

Genome annotation databases

GeneIDi101866571.
KEGGimcf:101866571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB169567 mRNA. Translation: BAE01649.1.
RefSeqiNP_001270552.1. NM_001283623.1.
UniGeneiMfa.8304.

3D structure databases

ProteinModelPortaliQ4R5H6.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimacfa-SPG21. Maspardin-ACP33-SPG21_like.

Proteomic databases

PRIDEiQ4R5H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101866571.
KEGGimcf:101866571.

Organism-specific databases

CTDi51324.

Phylogenomic databases

HOVERGENiHBG080704.
KOiK19367.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR026151. Maspardin.
[Graphical view]
PANTHERiPTHR15913. PTHR15913. 1 hit.
PfamiPF00561. Abhydrolase_1. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Frontal cortex.

Entry informationi

Entry nameiSPG21_MACFA
AccessioniPrimary (citable) accession number: Q4R5H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 19, 2005
Last modified: December 9, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.