Q4R596 (SAHH_MACFA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 44.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenosylhomocysteinase Short name=AdoHcyase EC=3.3.1.1 Alternative name(s): S-adenosyl-L-homocysteine hydrolase | ||||
| Gene names |
| ||||
| Organism | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) | ||||
| Taxonomic identifier | 9541 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca |
Protein attributes
| Sequence length | 432 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine By similarity. |
| Catalytic activity | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. |
| Cofactor | Binds 1 NAD per subunit By similarity. |
| Pathway | |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Cytoplasm By similarity. Melanosome By similarity. |
| Sequence similarities | Belongs to the adenosylhomocysteinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Hydrolase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 432 | 431 | Adenosylhomocysteinase | PRO_0000260218 | |||||
Regions | |||||||||
| Region | 183 – 350 | 168 | NAD binding By similarity | ||||||
Sites | |||||||||
| Binding site | 57 | 1 | Substrate By similarity | ||||||
| Binding site | 131 | 1 | Substrate By similarity | ||||||
| Binding site | 156 | 1 | Substrate By similarity | ||||||
| Binding site | 186 | 1 | Substrate By similarity | ||||||
| Binding site | 190 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine By similarity | ||||||
| Modified residue | 408 | 1 | N6-acetyllysine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB169648 mRNA. Translation: BAE01729.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1LI4 based on UniProtKB P23526. |
| ProteinModelPortal | Q4R596. |
| SMR | Q4R596. Positions 3-432. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q4R596. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Phylogenomic databases | |
| HOVERGEN | HBG005041. |
Family and domain databases | |
| InterPro | IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view] |
| PANTHER | PTHR23420. Ad_hcy_hydrolase. 1 hit. |
| Pfam | PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view] |
| PIRSF | PIRSF001109. Ad_hcy_hydrolase. 1 hit. |
| SMART | SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00936. AhcY. 1 hit. |
| PROSITE | PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SAHH_MACFA | ||||||||
| Accession | Primary (citable) accession number: Q4R596 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with