ID   PLD3_MACFA              Reviewed;         490 AA.
AC   Q4R583;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   24-MAR-2009, entry version 24.
DE   RecName: Full=Phospholipase D3;
DE            Short=PLD 3;
DE            EC=3.1.4.4;
DE   AltName: Full=Choline phosphatase 3;
DE   AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D3;
GN   Name=PLD3; ORFNames=QccE-15167;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: A phosphatidylcholine + H(2)O = choline + a
CC       phosphatidate.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type II membrane protein (By similarity).
CC   -!- PTM: Glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the phospholipase D family.
CC   -!- SIMILARITY: Contains 2 PLD phosphodiesterase domains.
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DR   EMBL; AB169661; BAE01742.1; -; mRNA.
DR   HOVERGEN; Q4R583; -.
DR   BRENDA; 3.1.4.4; 3438.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070290; F:NAPE-specific phospholipase D activity; IEA:EC.
DR   GO; GO:0004630; F:phospholipase D activity; IEA:EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR013582; PLD_envelope.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF08371; PLD_envelope; 1.
DR   Pfam; PF00614; PLDc; 2.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Hydrolase; Lipid degradation;
KW   Membrane; Repeat; Signal-anchor; Transmembrane.
FT   CHAIN         1    490       Phospholipase D3.
FT                                /FTId=PRO_0000280327.
FT   TOPO_DOM      1     38       Cytoplasmic (Potential).
FT   TRANSMEM     39     59       Signal-anchor for type II membrane
FT                                protein (Potential).
FT   TOPO_DOM     60    490       Lumenal (Potential).
FT   DOMAIN      196    223       PLD phosphodiesterase 1.
FT   DOMAIN      411    437       PLD phosphodiesterase 2.
FT   ACT_SITE    201    201       Potential.
FT   ACT_SITE    203    203       Potential.
FT   ACT_SITE    208    208       Potential.
FT   CARBOHYD    132    132       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   490 AA;  54852 MW;  ED2891E1920AB9DF CRC64;
     MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW
     EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL
     DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVN VRIAVSKPNG PQPQTDLQAL
     LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL
     ARDLTKIFEA YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC
     PSGRTPDLKA LLNVVDNARS FIYIAVMNYL PTLEFSHPHR FWPAIDDGLR RAAYERGVKV
     RLLVSCWRHS ESSMRAFLLS LAALRDNHTH SDIQVKLFVV PADEAQARIP YARVNHNKYM
     VTERATYIGT SNWSGNYFTE TAGTSLLVMQ NGRGSLRSQL EAIFLRDWDS PYSHDLDASA
     DSVGNACRLL
//