Reviewed, UniProtKB/Swiss-Prot Q4R581 (PLCD_MACFA)

Names and origin

Protein names

Recommended name:
    1-acyl-sn-glycerol-3-phosphate acyltransferase delta
    EC=2.3.1.51
Alternative name(s):
    1-acylglycerol-3-phosphate O-acyltransferase 4
      Short name=1-AGP acyltransferase 4
      Short name=1-AGPAT 4
    Lysophosphatidic acid acyltransferase delta
      Short name=LPAAT-delta

Gene names

Name:	AGPAT4
ORF Names:	QccE-15256

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone By similarity.
Catalytic activity	Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.
Sequence similarities	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-acylglycerol-3-phosphate O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	1-acyl-sn-glycerol-3-phosphate acyltransferase delta		PRO_0000293477
Regions
	Transmembrane	11 – 31	21	Potential
	Transmembrane	125 – 145	21	Potential
	Transmembrane	307 – 327	21	Potential
	Transmembrane	338 – 358	21	Potential
	Motif	96 – 101	6	HXXXXD motif

Sequences

	Sequence		Length	Mass (Da)
	Q4R581-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 5200441D0729BB67	FASTA	378	44,049
	10 20 30 40 50 60 MDLAGLLKSQ FLCHLVFCYV FIASGLIINT VQLFTLLLWP INKQLFRKIN CRLSYCISSQ 70 80 90 100 110 120 LVMLLEWWSG TECTIFTDPR AYPKYGKENA IVVLNHKFEI DFLCGWSLSE RFGLLGGSKV 130 140 150 160 170 180 LAKKELAYVP IIGWMWYFTE MVFCSRKWEQ DRKTVATSLQ HLRDYPEKYF FLIHCEGTRF 190 200 210 220 230 240 TEKKHEISMQ VARAKGLPRL KHHPLPRTKG FAITVRSLRN VVSAVYDCTL NFRNNENPTL 250 260 270 280 290 300 LGVLNGKKYH ADLYVRRIPL EDIPEDDDRC SAWLHKLYQE KDAFQEEYYR TGTFPETPMV 310 320 330 340 350 360 PPRRPWTLVN WLFWASLVLY PFFQFLVSMI RSGSSLTLAS FILVFFVASM GVRWMIGVTE 370 IDKGSAYGNS DSKQKQND

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB169663 mRNA. Translation: BAE01744.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R581.
Enzyme and pathway databases
BRENDA	2.3.1.51. 3438.
Family and domain databases
InterPro	IPR002123. Acyltransferase. [Graphical view]
Pfam	PF01553. Acyltransferase. 1 hit. [Graphical view]
SMART	SM00563. PlsC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLCD_MACFA

Accession

Primary (citable) accession number: Q4R581

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 19, 2005
Last modified:	October 13, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)