ID   MIF_MACFA               Reviewed;         115 AA.
AC   Q4R549;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   16-JUN-2009, entry version 27.
DE   RecName: Full=Macrophage migration inhibitory factor;
DE            Short=MIF;
DE            EC=5.3.2.1;
DE   AltName: Full=Phenylpyruvate tautomerase;
GN   Name=MIF; ORFNames=QccE-19130;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The expression of MIF at sites of inflammation suggest a
CC       role for the mediator in regulating the function of macrophage in
CC       host defense. Also acts as a phenylpyruvate tautomerase (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Keto-phenylpyruvate = enol-phenylpyruvate.
CC   -!- SUBUNIT: Homotrimer. Interacts with COPS5 and BNIPL (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the MIF family.
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DR   EMBL; AB169695; BAE01776.1; -; mRNA.
DR   SMR; Q4R549; 1-114, 2-115.
DR   PRIDE; Q4R549; -.
DR   HOVERGEN; Q4R549; -.
DR   BRENDA; 5.3.2.1; 3438.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0050178; F:phenylpyruvate tautomerase activity; IEA:EC.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR   InterPro; IPR014347; Tautomerase.
DR   Gene3D; G3DSA:3.30.429.10; Tautomerase; 1.
DR   PANTHER; PTHR11954; MIF; 1.
DR   Pfam; PF01187; MIF; 1.
DR   ProDom; PD004816; MIF; 1.
DR   PROSITE; PS01158; MIF; 1.
PE   3: Inferred from homology;
KW   Cytokine; Inflammatory response; Isomerase; Phosphoprotein.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    115       Macrophage migration inhibitory factor.
FT                                /FTId=PRO_0000158063.
FT   ACT_SITE      2      2       Proton acceptor; via imino nitrogen (By
FT                                similarity).
FT   MOD_RES      37     37       Phosphotyrosine (By similarity).
SQ   SEQUENCE   115 AA;  12476 MW;  56D51107C05286B2 CRC64;
     MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC
     SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA
//