ID   P5CR3_MACFA             Reviewed;         274 AA.
AC   Q4R531;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=Pyrroline-5-carboxylate reductase 3;
DE            Short=P5C reductase 3;
DE            Short=P5CR 3;
DE            EC=1.5.1.2;
DE   AltName: Full=Pyrroline-5-carboxylate reductase-like protein;
GN   Name=PYCRL; ORFNames=QccE-21944;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SUBUNIT: Homodecamer; composed of 5 homodimers (By similarity).
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; AB169713; BAE01794.1; -; mRNA.
DR   HOVERGEN; Q4R531; -.
DR   BRENDA; 1.5.1.2; 3438.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    274       Pyrroline-5-carboxylate reductase 3.
FT                                /FTId=PRO_0000324562.
SQ   SEQUENCE   274 AA;  28558 MW;  212CB2713A05E1E9 CRC64;
     MAAAGSATRR VGFVGAGRMA GAIAQGLIRA GKVEAQRIVA SAPTDRNLCH FQALGCQTTH
     SNQEVLQSCL LVIFATKPHI LPAVVAEVAP VVTAEHILVS VAAGVSLSTL EELLPPNTRV
     LRVLPNLPCV VQEGAIVMAR GRHVGSSETK LLQHLLEACG RCEEVPEAYV DIHTGLSGSG
     VAFVCAFSEA LAEGAIKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT
     TIYGLHALEQ GGLRAATMSA VEAATCRARE LSRK
//