Reviewed, UniProtKB/Swiss-Prot Q4R531 (P5CR3_MACFA)

Names and origin

Protein names

Recommended name:
    Pyrroline-5-carboxylate reductase 3
      Short name=P5C reductase 3
      Short name=P5CR 3
    EC=1.5.1.2
Alternative name(s):
    Pyrroline-5-carboxylate reductase-like protein

Gene names

Name:	PYCRL
ORF Names:	QccE-21944

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subunit structure	Homodecamer; composed of 5 homodimers By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Pyrroline-5-carboxylate reductase 3		PRO_0000324562
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R531-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 212CB2713A05E1E9	FASTA	274	28,558
	10 20 30 40 50 60 MAAAGSATRR VGFVGAGRMA GAIAQGLIRA GKVEAQRIVA SAPTDRNLCH FQALGCQTTH 70 80 90 100 110 120 SNQEVLQSCL LVIFATKPHI LPAVVAEVAP VVTAEHILVS VAAGVSLSTL EELLPPNTRV 130 140 150 160 170 180 LRVLPNLPCV VQEGAIVMAR GRHVGSSETK LLQHLLEACG RCEEVPEAYV DIHTGLSGSG 190 200 210 220 230 240 VAFVCAFSEA LAEGAIKMGM PSSLAHRIAA QTLLGTAKML LHEGQHPAQL RSDVCTPGGT 250 260 270 TIYGLHALEQ GGLRAATMSA VEAATCRARE LSRK

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB169713 mRNA. Translation: BAE01794.1.
3D structure databases
HSSP	HSSP built from PDB template 2AMF based on UniProtKB Q9A1S9.
SMR	Q4R531. Positions 9-274.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R531.
Enzyme and pathway databases
BRENDA	1.5.1.2. 3438.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
TIGRFAMs	TIGR00112. proC. 1 hit.
PROSITE	PS00521. P5CR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P5CR3_MACFA

Accession

Primary (citable) accession number: Q4R531

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	July 19, 2005
Last modified:	February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)