Reviewed, UniProtKB/Swiss-Prot Q4R517 (SUCB1_MACFA)

Names and origin

Protein names

Recommended name:
    Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial
    EC=6.2.1.5
Alternative name(s):
    Succinyl-CoA synthetase beta-A chain
      Short name=SCS-betaA
    ATP-specific succinyl-CoA synthetase subunit beta

Gene names

Name:	SUCLA2
ORF Names:	QflA-11886

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion By similarity
	Chain	53 – 463	411	Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial		PRO_0000270821
Regions
	Domain	61 – 288	228	ATP-grasp
Amino acid modifications
	Modified residue	84	1	Phosphotyrosine By similarity
	Modified residue	279	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R517-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: C960AA81E3F78E2D	FASTA	463	49,960
	10 20 30 40 50 60 MAASVFYGRL LAVATLRNHR PRTALGAAAQ VLGSSGLFNN HGLQVQQQQQ RNLSLHEYMS 70 80 90 100 110 120 MELLQEAGVS IPKGCVAKSP DEAYAVAKKL GSKDVVIKAQ VLAGGRGKGT FESGLKGGVK 130 140 150 160 170 180 IVFSPEEAKA VSSQMIGKKL FTKQTGEKGR ICNQVLVCER KYPRREYYFA ITMERSFQGP 190 200 210 220 230 240 VLIGSSQGGV NIEDVAAETP EAIITEPIDI EEGIKKEQAL QLAQKMGFPP NIVESAAENM 250 260 270 280 290 300 VKLYSLFLKY DATMIEINPM VEDSDGAVLC MDAKINFDSN SAYRQKKIFD LQDWTQEDER 310 320 330 340 350 360 DKDAAQANLN YIGLDGNIGC LVNGAGLAMA TMDIIKLHGG TPANFLDVGG GATVHQVTEA 370 380 390 400 410 420 FKLITSDKKV LAILVNIFGG IMSCDVIAQG IVTALKDLEI KIPVVVRLQG TRVDDAKALI 430 440 450 460 AGSGLKILAC DDLDEAARMV VKLSEIVTLA KQAHVDVKFQ LPI

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Frontal cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB169727 mRNA. Translation: BAE01808.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R517.
Enzyme and pathway databases
BRENDA	6.2.1.5. 3438.
Family and domain databases
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01016. sucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCB1_MACFA

Accession

Primary (citable) accession number: Q4R517

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)