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Q4R502

- IDHP_MACFA

UniProt

Q4R502 - IDHP_MACFA

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Protein

Isocitrate dehydrogenase [NADP], mitochondrial

Gene
IDH2, QnpA-13564
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex By similarity.

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei117 – 1171Substrate By similarity
Binding sitei122 – 1221NADP By similarity
Binding sitei149 – 1491Substrate By similarity
Binding sitei172 – 1721Substrate By similarity
Sitei179 – 1791Critical for catalysis By similarity
Sitei251 – 2511Critical for catalysis By similarity
Metal bindingi291 – 2911Magnesium or manganese By similarity
Binding sitei299 – 2991NADP By similarity
Metal bindingi314 – 3141Magnesium or manganese By similarity
Binding sitei367 – 3671NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi115 – 1173NADP By similarity
Nucleotide bindingi349 – 3546NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB
  2. magnesium ion binding Source: UniProtKB
  3. NAD binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: UniProtKB
  2. glyoxylate cycle Source: UniProtKB-KW
  3. isocitrate metabolic process Source: UniProtKB
  4. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP], mitochondrial (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
ICD-M
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:IDH2
ORF Names:QnpA-13564
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3939Mitochondrion By similarityAdd
BLAST
Chaini40 – 452413Isocitrate dehydrogenase [NADP], mitochondrialPRO_0000236186Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451N6-acetyllysine By similarity
Modified residuei48 – 481N6-acetyllysine By similarity
Modified residuei67 – 671N6-acetyllysine By similarity
Modified residuei69 – 691N6-acetyllysine By similarity
Modified residuei80 – 801N6-acetyllysine; alternate By similarity
Modified residuei80 – 801N6-succinyllysine; alternate By similarity
Modified residuei106 – 1061N6-acetyllysine; alternate By similarity
Modified residuei106 – 1061N6-succinyllysine; alternate By similarity
Modified residuei155 – 1551N6-acetyllysine By similarity
Modified residuei166 – 1661N6-acetyllysine; alternate By similarity
Modified residuei166 – 1661N6-succinyllysine; alternate By similarity
Modified residuei180 – 1801N6-acetyllysine; alternate By similarity
Modified residuei180 – 1801N6-succinyllysine; alternate By similarity
Modified residuei193 – 1931N6-acetyllysine; alternate By similarity
Modified residuei193 – 1931N6-succinyllysine; alternate By similarity
Modified residuei199 – 1991N6-acetyllysine By similarity
Modified residuei256 – 2561N6-acetyllysine; alternate By similarity
Modified residuei256 – 2561N6-succinyllysine; alternate By similarity
Modified residuei263 – 2631N6-acetyllysine By similarity
Modified residuei272 – 2721N6-acetyllysine By similarity
Modified residuei275 – 2751N6-acetyllysine By similarity
Modified residuei280 – 2801N6-acetyllysine By similarity
Modified residuei282 – 2821N6-acetyllysine; alternate By similarity
Modified residuei282 – 2821N6-succinyllysine; alternate By similarity
Modified residuei384 – 3841N6-acetyllysine; alternate By similarity
Modified residuei384 – 3841N6-succinyllysine; alternate By similarity
Modified residuei400 – 4001N6-acetyllysine By similarity
Modified residuei413 – 4131N6-acetyllysine By similarity
Modified residuei442 – 4421N6-acetyllysine By similarity

Post-translational modificationi

Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3 By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ4R502.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ4R502.
SMRiQ4R502. Positions 40-452.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni134 – 1407Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG006119.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R502-1 [UniParc]FASTAAdd to Basket

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MAGYLRVVRS LCRASGSRPA WAPAALTAPT SQEQTRRHYA DKRIKVAKPV    50
VEMDGDEMTR IIWQFIKEKL ILPHVDIQLK YFDLGLPNRD QTDDQVTIDS 100
ALATQKYSVA VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGTVFRE 150
PIICKNIPRL VPGWTKPITI GRHAHGDQYK ATDFVADRAG TFKMVFTPKD 200
GSGVKEWEVY NFPAGGVGMG MYNTDESISG FAHSCFQYAI QKKWPLYMST 250
KNTILKAYDG RFKDIFQEIF DKHYKTDFDK NKIWYEHRLI DDMVAQVLKS 300
SGGFVWACKN YDGDVQSDIL AQGFGSLGLM TSVLVCPDGK TIEAEAAHGT 350
VTRHYREHQK GRPTSTNPIA SIFAWTRGLE HRGKLDGNQD LIRFAQTLEK 400
VCVETVESGA MTKDLAGCIH GLSNVKLNEH FLNTTDFLDT IKSNLDRALG 450
RQ 452
Length:452
Mass (Da):50,883
Last modified:July 19, 2005 - v1
Checksum:iBBB5D9C734BD8844
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB169742 mRNA. Translation: BAE01823.1.
RefSeqiNP_001271517.1. NM_001284588.1.
UniGeneiMfa.8831.

Genome annotation databases

GeneIDi101925784.
KEGGimcf:101925784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB169742 mRNA. Translation: BAE01823.1 .
RefSeqi NP_001271517.1. NM_001284588.1.
UniGenei Mfa.8831.

3D structure databases

ProteinModelPortali Q4R502.
SMRi Q4R502. Positions 40-452.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q4R502.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101925784.
KEGGi mcf:101925784.

Organism-specific databases

CTDi 3418.

Phylogenomic databases

HOVERGENi HBG006119.
KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Parietal cortex.

Entry informationi

Entry nameiIDHP_MACFA
AccessioniPrimary (citable) accession number: Q4R502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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