Reviewed, UniProtKB/Swiss-Prot Q4R4W5 (IDI1_MACFA)

Names and origin

Protein names

Recommended name:
    Isopentenyl-diphosphate Delta-isomerase 1
    EC=5.3.3.2
Alternative name(s):
    Isopentenyl pyrophosphate isomerase 1
      Short name=IPP isomerase 1
      Short name=IPPI1

Gene names

Name:	IDI1
ORF Names:	QtrA-12624

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	227 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity.
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate.
Cofactor	Binds 1 magnesium ion per subunit By similarity.
Pathway	Isoprenoid biosynthesis; dimethylallyl-PP biosynthesis; dimethylallyl-PP from isopentenyl-PP: step 1/1.
Subunit structure	Monomer By similarity.
Subcellular location	Peroxisome By similarity.
Sequence similarities	Belongs to the IPP isomerase type 1 family.

Ontologies

Keywords
Biological process	Carotenoid biosynthesis Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Peroxisome
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	carotenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 227	227	Isopentenyl-diphosphate Delta-isomerase 1		PRO_0000205223
Regions
	Motif	225 – 227	3	Microbody targeting signal
Sites
	Active site	86	1
	Active site	148	1
	Metal binding	40	1	Magnesium By similarity
	Metal binding	51	1	Magnesium By similarity
	Metal binding	146	1	Magnesium By similarity
	Metal binding	148	1	Magnesium By similarity
	Binding site	36	1	Substrate By similarity
	Binding site	70	1	Substrate By similarity
	Binding site	74	1	Substrate By similarity
	Binding site	87	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R4W5-1 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: 0E5F3AF0A726CA64	FASTA	227	26,410
	10 20 30 40 50 60 MPEINTDHLD KQQVQLLAEM CILIDENDNK IGAETKKNCH LNENIEKGLL HRAFSVFLFN 70 80 90 100 110 120 TENKLLLQQR SDAKITFPGC FTNTCCSHPL SNPGELEEND ALGVRRAAQR RLKAELGIPL 130 140 150 160 170 180 EEVPPEEINY LTRIHYKAQS DGIWGEHEID YILFVRKNVT LNPDPNEIKS FCYVSKEELK 190 200 210 220 ELLKKAANGE IKITPWFQII AETFLFKWWD NLNHLNQFVD HEKIHRM

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Temporal cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB169779 mRNA. Translation: BAE01860.1. Different initiation.
3D structure databases
SMR	Q4R4W5. Positions 8-227.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R4W5.
Enzyme and pathway databases
BRENDA	5.3.3.2. 3438.
Family and domain databases
InterPro	IPR011876. IsopentenylPP_isomerase_typ1. IPR000086. NUDIX_hydrolase_core. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
PANTHER	PTHR10885. IPP_isom_1. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PIRSF	PIRSF018427. Isopntndiph_ism. 1 hit.
ProDom	PD004109. IPP_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR02150. IPP_isom_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI1_MACFA

Accession

Primary (citable) accession number: Q4R4W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	June 16, 2009
This is version 24 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)