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Q4R4V2

- PPM1G_MACFA

UniProt

Q4R4V2 - PPM1G_MACFA

Protein

Protein phosphatase 1G

Gene

PPM1G

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi60 – 601Manganese 2By similarity
    Metal bindingi61 – 611Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi442 – 4421Manganese 2By similarity
    Metal bindingi497 – 4971Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1G (EC:3.1.3.16)
    Gene namesi
    Name:PPM1G
    ORF Names:QccE-12260
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Protein phosphatase 1GPRO_0000286608Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831PhosphoserineBy similarity
    Modified residuei384 – 3841N6-acetyllysineBy similarity
    Modified residuei528 – 5281PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ4R4V2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4R4V2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi258 – 32770Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi266 – 2727Poly-Glu
    Compositional biasi306 – 3116Poly-Glu
    Compositional biasi540 – 5456Poly-Lys

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    HOVERGENiHBG053647.
    KOiK17499.

    Family and domain databases

    Gene3Di3.60.40.10. 2 hits.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 2 hits.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4R4V2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAYLSQPNT VKCSGDGVGA PRLPLSYGFS AMQGWRVSME DAHNCIPELD    50
    SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA 100
    IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT 150
    MTIEELLTRY GQNCHKGPPH SKSGAGTGEE PRSQGLNGEA GPEDSTREAP 200
    SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR 250
    VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300
    AEEDDEEEEE EEMMVPGMEG KEEPGSDSGT TAVVALIRGK QLIVANAGDS 350
    RCVVSEAGKA LDMSYDHKPE DEVELARIKN AGGKVTMDGR VNGGLNLSRA 400
    IGDHFYKRNK NLPPEEQMIS ALPDIKVLTL TDDHEFMVIA CDGIWNVMSS 450
    QEVVDFIQSK ISQRDENGEL RLLSSIVEEL LDQCLAPDTS GDGTGCDNMT 500
    CIIICFKPRN TAELQPESGK RKLEEVLSTE GAEENGNSDK KKKAKRD 547
    Length:547
    Mass (Da):59,474
    Last modified:July 19, 2005 - v1
    Checksum:iF854E511D3430F16
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB169792 mRNA. Translation: BAE01873.1.
    RefSeqiNP_001271868.1. NM_001284939.1.
    UniGeneiMfa.1169.

    Genome annotation databases

    GeneIDi101865411.
    KEGGimcf:101865411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB169792 mRNA. Translation: BAE01873.1 .
    RefSeqi NP_001271868.1. NM_001284939.1.
    UniGenei Mfa.1169.

    3D structure databases

    ProteinModelPortali Q4R4V2.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q4R4V2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 101865411.
    KEGGi mcf:101865411.

    Organism-specific databases

    CTDi 5496.

    Phylogenomic databases

    HOVERGENi HBG053647.
    KOi K17499.

    Family and domain databases

    Gene3Di 3.60.40.10. 2 hits.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 2 hits.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
      International consortium for macaque cDNA sequencing and analysis
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiPPM1G_MACFA
    AccessioniPrimary (citable) accession number: Q4R4V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3