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Q4R4V2

- PPM1G_MACFA

UniProt

Q4R4V2 - PPM1G_MACFA

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Protein

Protein phosphatase 1G

Gene
PPM1G, QccE-12260
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Manganese 1 By similarity
Metal bindingi60 – 601Manganese 2 By similarity
Metal bindingi61 – 611Manganese 1; via carbonyl oxygen By similarity
Metal bindingi442 – 4421Manganese 2 By similarity
Metal bindingi497 – 4971Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1G (EC:3.1.3.16)
Gene namesi
Name:PPM1G
ORF Names:QccE-12260
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Protein phosphatase 1GPRO_0000286608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine By similarity
Modified residuei384 – 3841N6-acetyllysine By similarity
Modified residuei528 – 5281Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ4R4V2.

Structurei

3D structure databases

ProteinModelPortaliQ4R4V2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 32770Asp/Glu-rich (acidic)Add
BLAST
Compositional biasi266 – 2727Poly-Glu
Compositional biasi306 – 3116Poly-Glu
Compositional biasi540 – 5456Poly-Lys

Sequence similaritiesi

Belongs to the PP2C family.

Phylogenomic databases

HOVERGENiHBG053647.
KOiK17499.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 2 hits.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4R4V2-1 [UniParc]FASTAAdd to Basket

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MGAYLSQPNT VKCSGDGVGA PRLPLSYGFS AMQGWRVSME DAHNCIPELD    50
SETAMFSVYD GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA 100
IDAKLTTEEV IKELAQIAGR PTEDEDEKEK VADEDDVDNE EAALLHEEAT 150
MTIEELLTRY GQNCHKGPPH SKSGAGTGEE PRSQGLNGEA GPEDSTREAP 200
SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS CSSASDKLPR 250
VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300
AEEDDEEEEE EEMMVPGMEG KEEPGSDSGT TAVVALIRGK QLIVANAGDS 350
RCVVSEAGKA LDMSYDHKPE DEVELARIKN AGGKVTMDGR VNGGLNLSRA 400
IGDHFYKRNK NLPPEEQMIS ALPDIKVLTL TDDHEFMVIA CDGIWNVMSS 450
QEVVDFIQSK ISQRDENGEL RLLSSIVEEL LDQCLAPDTS GDGTGCDNMT 500
CIIICFKPRN TAELQPESGK RKLEEVLSTE GAEENGNSDK KKKAKRD 547
Length:547
Mass (Da):59,474
Last modified:July 19, 2005 - v1
Checksum:iF854E511D3430F16
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB169792 mRNA. Translation: BAE01873.1.
RefSeqiNP_001271868.1. NM_001284939.1.
UniGeneiMfa.1169.

Genome annotation databases

GeneIDi101865411.
KEGGimcf:101865411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB169792 mRNA. Translation: BAE01873.1 .
RefSeqi NP_001271868.1. NM_001284939.1.
UniGenei Mfa.1169.

3D structure databases

ProteinModelPortali Q4R4V2.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q4R4V2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 101865411.
KEGGi mcf:101865411.

Organism-specific databases

CTDi 5496.

Phylogenomic databases

HOVERGENi HBG053647.
KOi K17499.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 2 hits.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPPM1G_MACFA
AccessioniPrimary (citable) accession number: Q4R4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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