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Q4R4V2 (PPM1G_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein phosphatase 1G
EC=3.1.3.16
Gene names
Name:PPM1G
ORF Names:QccE-12260
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphoprotein + H2O = a protein + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the PP2C family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
Phosphoprotein
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein serine/threonine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Protein phosphatase 1G
PRO_0000286608

Regions

Compositional bias258 – 32770Asp/Glu-rich (acidic)
Compositional bias266 – 2727Poly-Glu
Compositional bias306 – 3116Poly-Glu
Compositional bias540 – 5456Poly-Lys

Sites

Metal binding601Manganese 1 By similarity
Metal binding601Manganese 2 By similarity
Metal binding611Manganese 1; via carbonyl oxygen By similarity
Metal binding4421Manganese 2 By similarity
Metal binding4971Manganese 2 By similarity

Amino acid modifications

Modified residue1831Phosphoserine By similarity
Modified residue3841N6-acetyllysine By similarity
Modified residue5281Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R4V2 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: F854E511D3430F16

FASTA54759,474
        10         20         30         40         50         60 
MGAYLSQPNT VKCSGDGVGA PRLPLSYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 

        70         80         90        100        110        120 
GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 

       130        140        150        160        170        180 
PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGAGTGEE 

       190        200        210        220        230        240 
PRSQGLNGEA GPEDSTREAP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS 

       250        260        270        280        290        300 
CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 

       310        320        330        340        350        360 
AEEDDEEEEE EEMMVPGMEG KEEPGSDSGT TAVVALIRGK QLIVANAGDS RCVVSEAGKA 

       370        380        390        400        410        420 
LDMSYDHKPE DEVELARIKN AGGKVTMDGR VNGGLNLSRA IGDHFYKRNK NLPPEEQMIS 

       430        440        450        460        470        480 
ALPDIKVLTL TDDHEFMVIA CDGIWNVMSS QEVVDFIQSK ISQRDENGEL RLLSSIVEEL 

       490        500        510        520        530        540 
LDQCLAPDTS GDGTGCDNMT CIIICFKPRN TAELQPESGK RKLEEVLSTE GAEENGNSDK 


KKKAKRD

« Hide

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB169792 mRNA. Translation: BAE01873.1.

3D structure databases

HSSPHSSP built from PDB template 1A6Q based on UniProtKB P35813.
ProteinModelPortalQ4R4V2.
ModBaseSearch...

Proteomic databases

PRIDEQ4R4V2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG053647.

Family and domain databases

Gene3D3.60.40.10. 2 hits.
InterProIPR001932. PP2C-like.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 2 hits.
[Graphical view]
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. PP2C-related. 1 hit.
PROSITEPS01032. PP2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePPM1G_MACFA
AccessionPrimary (citable) accession number: Q4R4V2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 19, 2005
Last modified: March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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