ID   LGMN_MACFA              Reviewed;         433 AA.
AC   Q4R4T8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 19.
DE   RecName: Full=Legumain;
DE            EC=3.4.22.34;
DE   AltName: Full=Asparaginyl endopeptidase;
DE   AltName: Full=Protease, cysteine 1;
DE   Flags: Precursor;
GN   Name=LGMN; Synonyms=PRSC1; ORFNames=QccE-20451;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has a strict specificity for hydrolysis of asparaginyl
CC       bonds. Can also cleave aspartyl bonds slowly, especially under
CC       acidic conditions. May be involved in the processing of proteins
CC       for MHC class II antigen presentation in the lysosomal/endosomal
CC       system (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of proteins and small molecule
CC       substrates at -Asn-|-Xaa- bonds.
CC   -!- SUBCELLULAR LOCATION: Lysosome (By similarity).
CC   -!- PTM: Glycosylated (Probable).
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
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DR   EMBL; AB169806; BAE01887.1; -; mRNA.
DR   MEROPS; C13.004; -.
DR   HOVERGEN; Q4R4T8; -.
DR   BRENDA; 3.4.22.34; 3438.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; Peptidase_C13; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
DR   PRINTS; PR00776; HEMOGLOBNASE.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Hydrolase; Lysosome; Protease; Signal; Thiol protease;
KW   Zymogen.
FT   SIGNAL        1     17       By similarity.
FT   CHAIN        18    323       Legumain.
FT                                /FTId=PRO_0000259472.
FT   PROPEP      324    433       By similarity.
FT                                /FTId=PRO_0000259473.
FT   ACT_SITE    148    148       Potential.
FT   ACT_SITE    189    189       Potential.
FT   SITE        323    324       Cleavage; by autolysis (By similarity).
FT   CARBOHYD     91     91       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    167    167       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    263    263       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    272    272       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   433 AA;  49438 MW;  872951A13370D504 CRC64;
     MVWKVAVFLS VTLGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG
     IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD
     AEAVKGIGSG KVLKSGPQDH VFVYFTDHGS TGILVFPNED LHVKDLNETI YYMYKHKMYR
     KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED
     SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKHKA SSPLSLPPVT
     HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE
     AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR
     IKLSMDHVCL GHY
//