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Reviewed, UniProtKB/Swiss-Prot Q4R4T8 (LGMN_MACFA)

Last modified June 16, 2009. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Legumain
    EC=3.4.22.34
Alternative name(s):
    Asparaginyl endopeptidase
    Protease, cysteine 1
Gene names
Name: LGMN
Synonyms: PRSC1
ORF Names: QccE-20451
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

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Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system By similarity.

Catalytic activity

Hydrolysis of proteins and small molecule substrates at -Asn-|-Xaa- bonds.

Subcellular location

Lysosome By similarity.

Post-translational modification

Glycosylated Probable.

Sequence similarities

Belongs to the peptidase C13 family.

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Ontologies

Keywords
   Cellular componentLysosome
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   PTMGlycoprotein
Zymogen
Gene Ontology (GO)
   Biological processproteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular componentlysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioncysteine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 323306Legumain
PRO_0000259472
Propeptide324 – 433110 By similarity
PRO_0000259473

Sites

Active site1481 Potential
Active site1891 Potential
Site323 – 3242Cleavage; by autolysis By similarity

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
Q4R4T8-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 872951A13370D504

FASTA43349,438
        10         20         30         40         50         60 
MVWKVAVFLS VTLGIGAVPI DDPEDGGKHW VVIVAGSNGW YNYRHQADAC HAYQIIHRNG 

        70         80         90        100        110        120 
IPDEQIVVMM YDDIAYSEDN PTPGIVINRP NGTDVYQGVP KDYTGEDVTP QNFLAVLRGD 

       130        140        150        160        170        180 
AEAVKGIGSG KVLKSGPQDH VFVYFTDHGS TGILVFPNED LHVKDLNETI YYMYKHKMYR 

       190        200        210        220        230        240 
KMVFYIEACE SGSMMNHLPD NINVYATTAA NPRESSYACY YDEKRSTYLG DWYSVNWMED 

       250        260        270        280        290        300 
SDVEDLTKET LHKQYHLVKS HTNTSHVMQY GNKTISTMKV MQFQGMKHKA SSPLSLPPVT 

       310        320        330        340        350        360 
HLDLTPSPDV PLTIMKRKLM NTNDLEESRQ LTEEIQRHLD ARHLIEKSVR KIVSLLAASE 

       370        380        390        400        410        420 
AEVEQLLSER APLTGHSCYP EALLHFRTHC FNWHSPTYEY ALRHLYVLVN LCEKPYPLHR 

       430 
IKLSMDHVCL GHY

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References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

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Cross-references

Sequence databases

AB169806 mRNA. Translation: BAE01887.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

MEROPSC13.004.

Phylogenomic databases

HOVERGENQ4R4T8.

Enzyme and pathway databases

BRENDA3.4.22.34. 3438.

Family and domain databases

InterProIPR001096. Peptidase_C13.
[Graphical view]
PANTHERPTHR12000. Peptidase_C13. 1 hit.
PfamPF01650. Peptidase_C13. 1 hit.
[Graphical view]
PRINTSPR00776. HEMOGLOBNASE.
ProtoNetSearch...

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Entry information

Entry nameLGMN_MACFA
AccessionPrimary (citable) accession number: Q4R4T8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 19, 2005
Last modified: June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents