ID   ACBG1_MACFA             Reviewed;         724 AA.
AC   Q4R4P9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   16-JUN-2009, entry version 24.
DE   RecName: Full=Long-chain-fatty-acid--CoA ligase ACSBG1;
DE            EC=6.2.1.3;
DE   AltName: Full=Acyl-CoA synthetase bubblegum family member 1;
GN   Name=ACSBG1; ORFNames=QtrA-12214;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates activation of long-chain fatty acids for both
CC       synthesis of cellular lipids, and degradation via beta-oxidation.
CC       Able to activate long-chain fatty acids. Can activate diverse
CC       saturated, monosaturated and polyunsaturated fatty acids (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a long-chain carboxylic acid + CoA = AMP
CC       + diphosphate + an acyl-CoA.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasmic
CC       vesicle (By similarity). Microsome (By similarity). Endoplasmic
CC       reticulum (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family. Bubblegum subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE01926.1; Type=Frameshift; Positions=601;
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DR   EMBL; AB169845; BAE01926.1; ALT_FRAME; mRNA.
DR   HOVERGEN; Q4R4P9; -.
DR   BRENDA; 6.2.1.3; 3438.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004467; F:long-chain-fatty-acid-CoA ligase activity; IEA:EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   Pfam; PF00501; AMP-binding; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum;
KW   Fatty acid metabolism; Ligase; Lipid metabolism; Microsome;
KW   Nucleotide-binding; Phosphoprotein.
FT   CHAIN         1    724       Long-chain-fatty-acid--CoA ligase ACSBG1.
FT                                /FTId=PRO_0000315809.
FT   NP_BIND     282    290       ATP (By similarity).
FT   NP_BIND     472    477       ATP (By similarity).
FT   BINDING     550    550       ATP (By similarity).
FT   BINDING     565    565       ATP (By similarity).
FT   BINDING     701    701       ATP (By similarity).
FT   MOD_RES     135    135       Phosphotyrosine (By similarity).
FT   MOD_RES     138    138       Phosphotyrosine (By similarity).
FT   MOD_RES     139    139       Phosphotyrosine (By similarity).
FT   MOD_RES     658    658       Phosphotyrosine (By similarity).
SQ   SEQUENCE   724 AA;  80998 MW;  FD4738EC60704BF3 CRC64;
     MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMTVGTTQEK LKTSSLTDRQ PLSKESLNHA
     LKLSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDFS
     ALGFKCQDKW EHISYSQYYL LARRAAKGFL KLGLERAHSV AILGFNSPEW FFSAVGTVFA
     GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KVWKQLPHLK AVVIYKEPPP
     NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT
     WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL
     VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL
     KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMTAETQ HFFLGLNIRL YAGYGLSETS
     GPHFMSSPCN YRLYSSGKLV PGCRVKLVNQ DTEGIGEICL WGRTIFMGYL NMEDKTCEAI
     DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI
     GTDQRKFLSM LLTLKCTLDP DTSDPTDNLT EQAVEFCQRV GSRATTVSEI VGKDEAVYQA
     IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKDIIDSFYR
     EQKM
//