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Q4R4P9 (ACBG1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase ACSBG1

EC=6.2.1.3
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 1
Gene names
Name:ACSBG1
ORF Names:QtrA-12214
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length724 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Microsome By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.

Sequence caution

The sequence BAE01926.1 differs from that shown. Reason: Frameshift at position 601.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 724724Long-chain-fatty-acid--CoA ligase ACSBG1
PRO_0000315809

Regions

Nucleotide binding282 – 2909ATP By similarity
Nucleotide binding472 – 4776ATP By similarity

Sites

Binding site5501ATP By similarity
Binding site5651ATP By similarity
Binding site7011ATP By similarity

Amino acid modifications

Modified residue6581Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R4P9 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: FD4738EC60704BF3

FASTA72480,998
        10         20         30         40         50         60 
MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMTVGTTQEK LKTSSLTDRQ PLSKESLNHA 

        70         80         90        100        110        120 
LKLSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDFS 

       130        140        150        160        170        180 
ALGFKCQDKW EHISYSQYYL LARRAAKGFL KLGLERAHSV AILGFNSPEW FFSAVGTVFA 

       190        200        210        220        230        240 
GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KVWKQLPHLK AVVIYKEPPP 

       250        260        270        280        290        300 
NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT 

       310        320        330        340        350        360 
WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL 

       370        380        390        400        410        420 
VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL 

       430        440        450        460        470        480 
KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMTAETQ HFFLGLNIRL YAGYGLSETS 

       490        500        510        520        530        540 
GPHFMSSPCN YRLYSSGKLV PGCRVKLVNQ DTEGIGEICL WGRTIFMGYL NMEDKTCEAI 

       550        560        570        580        590        600 
DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI 

       610        620        630        640        650        660 
GTDQRKFLSM LLTLKCTLDP DTSDPTDNLT EQAVEFCQRV GSRATTVSEI VGKDEAVYQA 

       670        680        690        700        710        720 
IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKDIIDSFYR 


EQKM 

« Hide

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Temporal cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB169845 mRNA. Translation: BAE01926.1. Frameshift.
UniGeneMfa.8976.

3D structure databases

ProteinModelPortalQ4R4P9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG054660.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACBG1_MACFA
AccessionPrimary (citable) accession number: Q4R4P9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families