ID   UCK1_MACFA              Reviewed;         254 AA.
AC   Q4R4K2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 28.
DE   RecName: Full=Uridine-cytidine kinase 1;
DE            Short=UCK 1;
DE            EC=2.7.1.48;
DE   AltName: Full=Uridine monophosphokinase 1;
DE   AltName: Full=Cytidine monophosphokinase 1;
GN   Name=UCK1; ORFNames=QnpA-18547;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphorylates uridine and cytidine to uridine
CC       monophosphate and cytidine monophosphate. Does not phosphorylate
CC       deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP
CC       as a phosphate donor (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
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DR   EMBL; AB169892; BAE01973.1; -; mRNA.
DR   HOVERGEN; Q4R4K2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:EC.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR006083; PRK_URK.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    254       Uridine-cytidine kinase 1.
FT                                /FTId=PRO_0000346100.
FT   NP_BIND      30     38       ATP (By similarity).
FT   BINDING      87     87       Substrate (By similarity).
FT   BINDING     115    115       Substrate (By similarity).
FT   BINDING     120    120       Substrate (By similarity).
FT   BINDING     146    146       Substrate (By similarity).
FT   BINDING     155    155       Substrate (By similarity).
FT   BINDING     163    163       Substrate (By similarity).
FT   BINDING     192    192       ATP (By similarity).
SQ   SEQUENCE   254 AA;  28683 MW;  AB5262AE6E02E168 CRC64;
     MASAGGDECE GAAPEADRPH QRPFLIGVSG GTASGKSTVC EKIMGLLGQN EVEQRQRKVV
     ILSQDRFYKV LTAEQKAKAL KGQYNFDHPD AFDNDLMHRT LKNIVEGKTV EVPTYDFVTH
     SSQEIRDMFH LRLFVDTDSD VRLSRRVLRD VRRGRDLEQI LTQYTTFVKP AFEEFCLPTK
     KYADVIIPRG VDNMVAINLI VQHIQDILNG DICKWHRGGS NGRSYKRTFS EPGDHPGMLT
     SGKRSHLESS SRPH
//