Reviewed, UniProtKB/Swiss-Prot Q4R4K2 (UCK1_MACFA)

Names and origin

Protein names

Recommended name:
    Uridine-cytidine kinase 1
      Short name=UCK 1
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase 1
    Cytidine monophosphokinase 1

Gene names

Name:	UCK1
ORF Names:	QnpA-18547

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor By similarity.
Catalytic activity	ATP + uridine = ADP + UMP. ATP + cytidine = ADP + CMP.
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Uridine-cytidine kinase 1		PRO_0000346100
Regions
	Nucleotide binding	30 – 38	9	ATP By similarity
Sites
	Binding site	87	1	Substrate By similarity
	Binding site	115	1	Substrate By similarity
	Binding site	120	1	Substrate By similarity
	Binding site	146	1	Substrate By similarity
	Binding site	155	1	Substrate By similarity
	Binding site	163	1	Substrate By similarity
	Binding site	192	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R4K2-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: AB5262AE6E02E168	FASTA	254	28,683
	10 20 30 40 50 60 MASAGGDECE GAAPEADRPH QRPFLIGVSG GTASGKSTVC EKIMGLLGQN EVEQRQRKVV 70 80 90 100 110 120 ILSQDRFYKV LTAEQKAKAL KGQYNFDHPD AFDNDLMHRT LKNIVEGKTV EVPTYDFVTH 130 140 150 160 170 180 SSQEIRDMFH LRLFVDTDSD VRLSRRVLRD VRRGRDLEQI LTQYTTFVKP AFEEFCLPTK 190 200 210 220 230 240 KYADVIIPRG VDNMVAINLI VQHIQDILNG DICKWHRGGS NGRSYKRTFS EPGDHPGMLT 250 SGKRSHLESS SRPH

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Parietal cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB169892 mRNA. Translation: BAE01973.1.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q4R4K2.
Family and domain databases
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
ProtoNet	Search...

Entry information

Entry name

UCK1_MACFA

Accession

Primary (citable) accession number: Q4R4K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)