ID   INP4B_MACFA             Reviewed;         813 AA.
AC   Q4R4D7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-MAR-2009, entry version 20.
DE   RecName: Full=Type II inositol-3,4-bisphosphate 4-phosphatase;
DE            EC=3.1.3.66;
DE   AltName: Full=Inositol polyphosphate 4-phosphatase type II;
GN   Name=INPP4B; ORFNames=QtsA-10790;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of
CC       phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-
CC       trisphosphate and inositol 1,4-bisphosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: 1-phosphatidyl-myo-inositol 3,4-bisphosphate +
CC       H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
CC   -!- ENZYME REGULATION: Strongly inhibited by inositol hexakisphosphate
CC       (By similarity).
CC   -!- PATHWAY: Signal transduction; phosphatidylinositol signaling
CC       pathway.
CC   -!- SIMILARITY: Belongs to the inositol-3,4-bisphosphate 4-phosphatase
CC       family.
CC   -!- SIMILARITY: Contains 1 C2 domain.
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DR   EMBL; AB178977; BAE02028.1; -; mRNA.
DR   HOVERGEN; Q4R4D7; -.
DR   BRENDA; 3.1.3.66; 3438.
DR   GO; GO:0034597; F:phosphatidyl-inositol-4,5-bisphosphate 4-ph...; IEA:EC.
DR   GO; GO:0016316; F:phosphatidylinositol-3,4-bisphosphate 4-pho...; IEA:EC.
DR   PROSITE; PS50004; C2; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Hydrolase.
FT   CHAIN         1    813       Type II inositol-3,4-bisphosphate 4-
FT                                phosphatase.
FT                                /FTId=PRO_0000190236.
FT   DOMAIN       25    149       C2.
SQ   SEQUENCE   813 AA;  91815 MW;  9A256E8AC42F8162 CRC64;
     MEIKEEGASE EGQHFLPAAQ ASDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN
     TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK
     SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLALSLRTS DGGKVVGTIE
     VSVVKMGEIE DGEADHITTD VRGQKCALVC ECTAPESVSS KGEKTLEFVP VNLHLQRMQV
     HSPHLKDALY DVITVGAPAA HFQGFKNGGL RKLLHRFETE RRNTGYQFIY YSPENTAKAK
     EVLSNINQLQ PLVATHADLL LNSASQHSPD SLKNSLKMLS EKTELFVHAF KDQLVRSALL
     ALYTARPGGV LKKPPSPKSS TEESSPQEQP PLMRRQDSIP HHSDYDEEEW DRVWANVGKS
     LNCIIAMVDK LIERDGGSEG SGSNNDGEKE PSLADSIPSH PREDWYEQLY PLILTLKDCM
     GEVVNRAKQS LTFVLLQELA YSLPQCLMLT LRRDIVFSQA LAGLVCGFII KLQTSLYDPG
     FLQQLHTVGL IVQYEGLLST YSDEIGMLED MAVGISDLKK VAFKIIEAKS NDVLPVVTGR
     REHYVVEVKL PARMFESLPL QIKEGQLLHV YPVLFNVGIN EQQTLAERFG DVSLQESINQ
     ENFELLQEYY KIFMEKMPPD YISHFQEQND LKALLENLHQ NIQSKKRKNV EIMWLAATIC
     RKLNGIRFTC CKSAKDRTSM SVTLEQCSIL RDEHQLHKDF FIRALDCMRR EGCRIENVLK
     NIKCRKYAFN MLQLMAFPKY YRPPEGTYGK ADT
//