Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q4R4D7 (INP4B_MACFA)

Last modified March 3, 2009. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Type II inositol-3,4-bisphosphate 4-phosphatase
    EC=3.1.3.66
Alternative name(s):
    Inositol polyphosphate 4-phosphatase type II
Gene names
Name: INPP4B
ORF Names: QtsA-10790
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Hide | Top

Protein attributes

Sequence length813 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate By similarity.

Catalytic activity

1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

Enzyme regulation

Strongly inhibited by inositol hexakisphosphate By similarity.

Pathway

Signal transduction; phosphatidylinositol signaling pathway.

Sequence similarities

Belongs to the inositol-3,4-bisphosphate 4-phosphatase family.

Contains 1 C2 domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 813813Type II inositol-3,4-bisphosphate 4-phosphatase
PRO_0000190236

Regions

Domain25 – 149125C2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q4R4D7-1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 9A256E8AC42F8162

FASTA81391,815
        10         20         30         40         50         60 
MEIKEEGASE EGQHFLPAAQ ASDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN 

        70         80         90        100        110        120 
TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK 

       130        140        150        160        170        180 
SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLALSLRTS DGGKVVGTIE 

       190        200        210        220        230        240 
VSVVKMGEIE DGEADHITTD VRGQKCALVC ECTAPESVSS KGEKTLEFVP VNLHLQRMQV 

       250        260        270        280        290        300 
HSPHLKDALY DVITVGAPAA HFQGFKNGGL RKLLHRFETE RRNTGYQFIY YSPENTAKAK 

       310        320        330        340        350        360 
EVLSNINQLQ PLVATHADLL LNSASQHSPD SLKNSLKMLS EKTELFVHAF KDQLVRSALL 

       370        380        390        400        410        420 
ALYTARPGGV LKKPPSPKSS TEESSPQEQP PLMRRQDSIP HHSDYDEEEW DRVWANVGKS 

       430        440        450        460        470        480 
LNCIIAMVDK LIERDGGSEG SGSNNDGEKE PSLADSIPSH PREDWYEQLY PLILTLKDCM 

       490        500        510        520        530        540 
GEVVNRAKQS LTFVLLQELA YSLPQCLMLT LRRDIVFSQA LAGLVCGFII KLQTSLYDPG 

       550        560        570        580        590        600 
FLQQLHTVGL IVQYEGLLST YSDEIGMLED MAVGISDLKK VAFKIIEAKS NDVLPVVTGR 

       610        620        630        640        650        660 
REHYVVEVKL PARMFESLPL QIKEGQLLHV YPVLFNVGIN EQQTLAERFG DVSLQESINQ 

       670        680        690        700        710        720 
ENFELLQEYY KIFMEKMPPD YISHFQEQND LKALLENLHQ NIQSKKRKNV EIMWLAATIC 

       730        740        750        760        770        780 
RKLNGIRFTC CKSAKDRTSM SVTLEQCSIL RDEHQLHKDF FIRALDCMRR EGCRIENVLK 

       790        800        810 
NIKCRKYAFN MLQLMAFPKY YRPPEGTYGK ADT

« Hide

Hide | Top

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Hide | Top

Cross-references

Sequence databases

AB178977 mRNA. Translation: BAE02028.1.

3D structure databases

ModBaseSearch...

Phylogenomic databases

HOVERGENQ4R4D7.

Enzyme and pathway databases

BRENDA3.1.3.66. 3438.

Family and domain databases

PROSITEPS50004. C2. False negative.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameINP4B_MACFA
AccessionPrimary (citable) accession number: Q4R4D7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 19, 2005
Last modified: March 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents