Q4R4D7 (INP4B_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type II inositol-3,4-bisphosphate 4-phosphatase
EC=3.1.3.66

Alternative name(s):
Inositol polyphosphate 4-phosphatase type II

Gene names

Name:	INPP4B
ORF Names:	QtsA-10790

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	813 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate By similarity.
Catalytic activity	1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Enzyme regulation	Strongly inhibited by inositol hexakisphosphate By similarity.
Pathway	Signal transduction; phosphatidylinositol signaling pathway.
Sequence similarities	Belongs to the inositol-3,4-bisphosphate 4-phosphatase family. Contains 1 C2 domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 813	813	Type II inositol-3,4-bisphosphate 4-phosphatase		PRO_0000190236
Regions
	Domain	25 – 149	125	C2
Amino acid modifications
	Modified residue	376	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R4D7 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 9A256E8AC42F8162	FASTA	813	91,815
	10 20 30 40 50 60 MEIKEEGASE EGQHFLPAAQ ASDPGDCQFT SIQKTPNEPQ LEFILACKDL VAPVRDRKLN 70 80 90 100 110 120 TLVQISVIHP VEQSLTRYSS TEIVEGTRDP LFLTGVTFPS EYPIYEETKI KLTVYDVKDK 130 140 150 160 170 180 SHDTVRTSVL PEHKDPPPEV GRSFLGYASF KVGELLKSKE QLLALSLRTS DGGKVVGTIE 190 200 210 220 230 240 VSVVKMGEIE DGEADHITTD VRGQKCALVC ECTAPESVSS KGEKTLEFVP VNLHLQRMQV 250 260 270 280 290 300 HSPHLKDALY DVITVGAPAA HFQGFKNGGL RKLLHRFETE RRNTGYQFIY YSPENTAKAK 310 320 330 340 350 360 EVLSNINQLQ PLVATHADLL LNSASQHSPD SLKNSLKMLS EKTELFVHAF KDQLVRSALL 370 380 390 400 410 420 ALYTARPGGV LKKPPSPKSS TEESSPQEQP PLMRRQDSIP HHSDYDEEEW DRVWANVGKS 430 440 450 460 470 480 LNCIIAMVDK LIERDGGSEG SGSNNDGEKE PSLADSIPSH PREDWYEQLY PLILTLKDCM 490 500 510 520 530 540 GEVVNRAKQS LTFVLLQELA YSLPQCLMLT LRRDIVFSQA LAGLVCGFII KLQTSLYDPG 550 560 570 580 590 600 FLQQLHTVGL IVQYEGLLST YSDEIGMLED MAVGISDLKK VAFKIIEAKS NDVLPVVTGR 610 620 630 640 650 660 REHYVVEVKL PARMFESLPL QIKEGQLLHV YPVLFNVGIN EQQTLAERFG DVSLQESINQ 670 680 690 700 710 720 ENFELLQEYY KIFMEKMPPD YISHFQEQND LKALLENLHQ NIQSKKRKNV EIMWLAATIC 730 740 750 760 770 780 RKLNGIRFTC CKSAKDRTSM SVTLEQCSIL RDEHQLHKDF FIRALDCMRR EGCRIENVLK 790 800 810 NIKCRKYAFN MLQLMAFPKY YRPPEGTYGK ADT

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB178977 mRNA. Translation: BAE02028.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG081796.
Family and domain databases
InterPro	IPR008973. C2_Ca/lipid-bd_dom_CaLB. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit.
PROSITE	PS50004. C2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

INP4B_MACFA

Accession

Primary (citable) accession number: Q4R4D7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	July 19, 2005
Last modified:	May 31, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program