Q4R3W4 (KAD8_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase 8
EC=2.7.4.3

Gene names

Name:	AK8
ORF Names:	QtsA-13756

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adenylate kinase. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subcellular location	Cytoplasm › cytosol By similarity.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB cytidylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Adenylate kinase 8		PRO_0000279384
Regions
	Nucleotide binding	275 – 282	8	ATP Potential
	Region	270 – 479	210	Adenylate kinase By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4R3W4 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 1A1B001390D88C59	FASTA	479	54,710
	10 20 30 40 50 60 MDSASVPHRI PPEMPQYGEE NHIFELMQNM LEQLLIHQPE DPIPFMIQHL HKDNDNVPRI 70 80 90 100 110 120 VILGPPASGK TTIAMWLCKH LNSSLLTLEN LVLNEFSLTA TKAKRLYLQR KTIPSALLVQ 130 140 150 160 170 180 LIQERLAEED CVKRGWILDG IPETREQALR IQTLGITPRH VIVLSAPDTV LIERNLGKRI 190 200 210 220 230 240 DPQTGEIYHT TFDWPPESEI QNRLMVPEDI SELETAQKLL EYHRNIVRVI PSYPKILKVI 250 260 270 280 290 300 SADQPCVDVF YQALTYVQSN HRTNAPFTPR VLLLGPVGSG KSLQAALLAQ KYRLVNVCCG 310 320 330 340 350 360 QLLKEAMADR TTFGELIQPF FEKEMAVLDS LLMKVLSQRL DQQDCIQKGW VLHGVPRDLD 370 380 390 400 410 420 QAHLLNSLGY NPNRVFFLNV PFDSIMERLT LRRIDPVTGE RYHLMYKPPP TMEILARLLQ 430 440 450 460 470 NPKDAEEQVK LKMDLSYRNS ADLEQLYGSA ITVNGDQDPY TVFEYIESGI INPLPKKIP

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB179151 mRNA. Translation: BAE02202.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZAK based on UniProtKB P43188.
ProteinModelPortal	Q4R3W4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG080569.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR007862. Adenylate_kinase_lid-dom. [Graphical view]
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 2 hits. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
SUPFAM	SSF57774. Adenylate_kinase_Znf_lid. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAD8_MACFA

Accession

Primary (citable) accession number: Q4R3W4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	July 19, 2005
Last modified:	September 21, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program