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Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulating eumelanin and phaeomelanin levels.By similarity

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathway: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi189 – 1891Zinc ABy similarity
Metal bindingi211 – 2111Zinc ABy similarity
Metal bindingi220 – 2201Zinc ABy similarity
Metal bindingi369 – 3691Zinc BBy similarity
Metal bindingi373 – 3731Zinc BBy similarity
Metal bindingi396 – 3961Zinc BBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_360198. Melanin biosynthesis.
UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 472449Lumenal, melanosomeSequence AnalysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence AnalysisAdd
BLAST
Topological domaini494 – 51926CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 519496L-dopachrome tautomerasePRO_0000240477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010135.

Structurei

3D structure databases

ProteinModelPortaliQ4R1H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301916.
GeneTreeiENSGT00500000044790.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiQ4R1H1.
KOiK01827.
OMAiANCSIYN.
OrthoDBiEOG7TJ3HG.
TreeFamiTF315865.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R1H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPFRWGLLL GCLGSALGPG AQAQFPRVCM TVGSLQAKEC CPPLGAEPSN
60 70 80 90 100
VCGSLEGRGR CAEVQADTRP WSGPYVLRNQ DDRERWPRKF FDRTCRCTGN
110 120 130 140 150
FAGYNCGDCK FGWTGPNCDQ KKPLVVRQNI HSLTAQEREQ FLGALDLAKN
160 170 180 190 200
TPHPDYVITT QHWLGLLGPN GTQPQIANCS IYDLFVWLHY YSVRDTLLGP
210 220 230 240 250
GRPYKAIDFS HQGPAFVTWH RYHLLWLERA LQRLTGNESF AVPYWNFATG
260 270 280 290 300
RNECDVCTDQ LLGAARPDDP TLISQNSRFS SWEIVCDSLD DYNRRVTLCN
310 320 330 340 350
GTYEGLLRRN QVGRNSEKLP SLKDIEDCLS LKQFDNPPFF QNSTFSFRNA
360 370 380 390 400
LEGFDKADGT LDSQVMSLHN LVHSFLNGTS ALPHSAANDP VFVVLHSFTD
410 420 430 440 450
AIFDEWMKRF SPPVDAWPQE LAPIGHNRMY NMVPFFPPVT NEELFLTADQ
460 470 480 490 500
LGYSYAIDLP VSVEGTPDWT TTLSVVMGML VVLVGLSALL LFLQYRRLRK
510
GYTPLMETQL SHKRYTEEA
Length:519
Mass (Da):58,573
Last modified:July 19, 2005 - v1
Checksum:iE44F33A8D8CD2292
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB207241 mRNA. Translation: BAD99582.1.
RefSeqiNP_001020398.1. NM_001025227.1.
UniGeneiSsc.42739.

Genome annotation databases

EnsembliENSSSCT00000010405; ENSSSCP00000010135; ENSSSCG00000009490.
GeneIDi574066.
KEGGissc:574066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB207241 mRNA. Translation: BAD99582.1.
RefSeqiNP_001020398.1. NM_001025227.1.
UniGeneiSsc.42739.

3D structure databases

ProteinModelPortaliQ4R1H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000010405; ENSSSCP00000010135; ENSSSCG00000009490.
GeneIDi574066.
KEGGissc:574066.

Organism-specific databases

CTDi1638.

Phylogenomic databases

eggNOGiNOG301916.
GeneTreeiENSGT00500000044790.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiQ4R1H1.
KOiK01827.
OMAiANCSIYN.
OrthoDBiEOG7TJ3HG.
TreeFamiTF315865.

Enzyme and pathway databases

UniPathwayiUPA00785.
ReactomeiREACT_360198. Melanin biosynthesis.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences and mapping of genes encoding porcine tyrosinase (TYR) and tyrosinase-related proteins (TYRP1 and TYRP2)."
    Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N., Awata T.
    Anim. Genet. 36:513-516(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiTYRP2_PIG
AccessioniPrimary (citable) accession number: Q4R1H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 19, 2005
Last modified: May 27, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.