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Q4R1H1

- TYRP2_PIG

UniProt

Q4R1H1 - TYRP2_PIG

Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Involved in regulating eumelanin and phaeomelanin levels.By similarity

    Catalytic activityi

    L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi189 – 1891Zinc ABy similarity
    Metal bindingi211 – 2111Zinc ABy similarity
    Metal bindingi220 – 2201Zinc ABy similarity
    Metal bindingi369 – 3691Zinc BBy similarity
    Metal bindingi373 – 3731Zinc BBy similarity
    Metal bindingi396 – 3961Zinc BBy similarity

    GO - Molecular functioni

    1. dopachrome isomerase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell development Source: Ensembl
    2. developmental pigmentation Source: Ensembl
    3. melanin biosynthetic process from tyrosine Source: UniProtKB
    4. positive regulation of neuroblast proliferation Source: Ensembl
    5. ventricular zone neuroblast division Source: Ensembl

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00785.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-dopachrome tautomerase (EC:5.3.3.12)
    Short name:
    DCT
    Short name:
    DT
    Alternative name(s):
    L-dopachrome Delta-isomerase
    Tyrosinase-related protein 2
    Short name:
    TRP-2
    Short name:
    TRP2
    Gene namesi
    Name:DCT
    Synonyms:TYRP2
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 11

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. melanosome Source: UniProtKB
    4. melanosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 519496L-dopachrome tautomerasePRO_0000240477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000010135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ4R1H1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 472449Lumenal, melanosomeSequence AnalysisAdd
    BLAST
    Topological domaini494 – 51926CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei473 – 49321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301916.
    GeneTreeiENSGT00500000044790.
    HOGENOMiHOG000118376.
    HOVERGENiHBG003553.
    KOiK01827.
    OMAiWPRKFFN.
    OrthoDBiEOG7TJ3HG.
    TreeFamiTF315865.

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4R1H1-1 [UniParc]FASTAAdd to Basket

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    MVPFRWGLLL GCLGSALGPG AQAQFPRVCM TVGSLQAKEC CPPLGAEPSN    50
    VCGSLEGRGR CAEVQADTRP WSGPYVLRNQ DDRERWPRKF FDRTCRCTGN 100
    FAGYNCGDCK FGWTGPNCDQ KKPLVVRQNI HSLTAQEREQ FLGALDLAKN 150
    TPHPDYVITT QHWLGLLGPN GTQPQIANCS IYDLFVWLHY YSVRDTLLGP 200
    GRPYKAIDFS HQGPAFVTWH RYHLLWLERA LQRLTGNESF AVPYWNFATG 250
    RNECDVCTDQ LLGAARPDDP TLISQNSRFS SWEIVCDSLD DYNRRVTLCN 300
    GTYEGLLRRN QVGRNSEKLP SLKDIEDCLS LKQFDNPPFF QNSTFSFRNA 350
    LEGFDKADGT LDSQVMSLHN LVHSFLNGTS ALPHSAANDP VFVVLHSFTD 400
    AIFDEWMKRF SPPVDAWPQE LAPIGHNRMY NMVPFFPPVT NEELFLTADQ 450
    LGYSYAIDLP VSVEGTPDWT TTLSVVMGML VVLVGLSALL LFLQYRRLRK 500
    GYTPLMETQL SHKRYTEEA 519
    Length:519
    Mass (Da):58,573
    Last modified:July 19, 2005 - v1
    Checksum:iE44F33A8D8CD2292
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB207241 mRNA. Translation: BAD99582.1.
    RefSeqiNP_001020398.1. NM_001025227.1.
    UniGeneiSsc.42739.

    Genome annotation databases

    EnsembliENSSSCT00000010405; ENSSSCP00000010135; ENSSSCG00000009490.
    GeneIDi574066.
    KEGGissc:574066.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB207241 mRNA. Translation: BAD99582.1 .
    RefSeqi NP_001020398.1. NM_001025227.1.
    UniGenei Ssc.42739.

    3D structure databases

    ProteinModelPortali Q4R1H1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000010135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000010405 ; ENSSSCP00000010135 ; ENSSSCG00000009490 .
    GeneIDi 574066.
    KEGGi ssc:574066.

    Organism-specific databases

    CTDi 1638.

    Phylogenomic databases

    eggNOGi NOG301916.
    GeneTreei ENSGT00500000044790.
    HOGENOMi HOG000118376.
    HOVERGENi HBG003553.
    KOi K01827.
    OMAi WPRKFFN.
    OrthoDBi EOG7TJ3HG.
    TreeFami TF315865.

    Enzyme and pathway databases

    UniPathwayi UPA00785 .

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and mapping of genes encoding porcine tyrosinase (TYR) and tyrosinase-related proteins (TYRP1 and TYRP2)."
      Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N., Awata T.
      Anim. Genet. 36:513-516(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skin.

    Entry informationi

    Entry nameiTYRP2_PIG
    AccessioniPrimary (citable) accession number: Q4R1H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3