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Q4R1H1

- TYRP2_PIG

UniProt

Q4R1H1 - TYRP2_PIG

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Protein
L-dopachrome tautomerase
Gene
DCT, TYRP2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in regulating eumelanin and phaeomelanin levels By similarity.

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi189 – 1891Zinc A By similarity
Metal bindingi211 – 2111Zinc A By similarity
Metal bindingi220 – 2201Zinc A By similarity
Metal bindingi369 – 3691Zinc B By similarity
Metal bindingi373 – 3731Zinc B By similarity
Metal bindingi396 – 3961Zinc B By similarity

GO - Molecular functioni

  1. dopachrome isomerase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell development Source: Ensembl
  2. developmental pigmentation Source: Ensembl
  3. melanin biosynthetic process from tyrosine Source: UniProtKB
  4. positive regulation of neuroblast proliferation Source: Ensembl
  5. ventricular zone neuroblast division Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 472449Lumenal, melanosome Reviewed prediction
Add
BLAST
Transmembranei473 – 49321Helical; Reviewed prediction
Add
BLAST
Topological domaini494 – 51926Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. melanosome Source: UniProtKB
  4. melanosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 519496L-dopachrome tautomerase
PRO_0000240477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi342 – 3421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi377 – 3771N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex By similarity.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000010135.

Structurei

3D structure databases

ProteinModelPortaliQ4R1H1.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301916.
GeneTreeiENSGT00500000044790.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
KOiK01827.
OMAiWPRKFFN.
OrthoDBiEOG7TJ3HG.
TreeFamiTF315865.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4R1H1-1 [UniParc]FASTAAdd to Basket

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MVPFRWGLLL GCLGSALGPG AQAQFPRVCM TVGSLQAKEC CPPLGAEPSN    50
VCGSLEGRGR CAEVQADTRP WSGPYVLRNQ DDRERWPRKF FDRTCRCTGN 100
FAGYNCGDCK FGWTGPNCDQ KKPLVVRQNI HSLTAQEREQ FLGALDLAKN 150
TPHPDYVITT QHWLGLLGPN GTQPQIANCS IYDLFVWLHY YSVRDTLLGP 200
GRPYKAIDFS HQGPAFVTWH RYHLLWLERA LQRLTGNESF AVPYWNFATG 250
RNECDVCTDQ LLGAARPDDP TLISQNSRFS SWEIVCDSLD DYNRRVTLCN 300
GTYEGLLRRN QVGRNSEKLP SLKDIEDCLS LKQFDNPPFF QNSTFSFRNA 350
LEGFDKADGT LDSQVMSLHN LVHSFLNGTS ALPHSAANDP VFVVLHSFTD 400
AIFDEWMKRF SPPVDAWPQE LAPIGHNRMY NMVPFFPPVT NEELFLTADQ 450
LGYSYAIDLP VSVEGTPDWT TTLSVVMGML VVLVGLSALL LFLQYRRLRK 500
GYTPLMETQL SHKRYTEEA 519
Length:519
Mass (Da):58,573
Last modified:July 19, 2005 - v1
Checksum:iE44F33A8D8CD2292
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB207241 mRNA. Translation: BAD99582.1.
RefSeqiNP_001020398.1. NM_001025227.1.
UniGeneiSsc.42739.

Genome annotation databases

EnsembliENSSSCT00000010405; ENSSSCP00000010135; ENSSSCG00000009490.
GeneIDi574066.
KEGGissc:574066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB207241 mRNA. Translation: BAD99582.1 .
RefSeqi NP_001020398.1. NM_001025227.1.
UniGenei Ssc.42739.

3D structure databases

ProteinModelPortali Q4R1H1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000010135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000010405 ; ENSSSCP00000010135 ; ENSSSCG00000009490 .
GeneIDi 574066.
KEGGi ssc:574066.

Organism-specific databases

CTDi 1638.

Phylogenomic databases

eggNOGi NOG301916.
GeneTreei ENSGT00500000044790.
HOGENOMi HOG000118376.
HOVERGENi HBG003553.
KOi K01827.
OMAi WPRKFFN.
OrthoDBi EOG7TJ3HG.
TreeFami TF315865.

Enzyme and pathway databases

UniPathwayi UPA00785 .

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequences and mapping of genes encoding porcine tyrosinase (TYR) and tyrosinase-related proteins (TYRP1 and TYRP2)."
    Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N., Awata T.
    Anim. Genet. 36:513-516(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiTYRP2_PIG
AccessioniPrimary (citable) accession number: Q4R1H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 19, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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