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Q4R1H1 (TYRP2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-dopachrome tautomerase

Short name=DCT
Short name=DT
EC=5.3.3.12
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name=TRP-2
Short name=TRP2
Gene names
Name:DCT
Synonyms:TYRP2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in regulating eumelanin and phaeomelanin levels By similarity.

Catalytic activity

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Pathway

Pigment biosynthesis; melanin biosynthesis.

Subunit structure

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex By similarity.

Subcellular location

Melanosome membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the tyrosinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 519496L-dopachrome tautomerase
PRO_0000240477

Regions

Topological domain24 – 472449Lumenal, melanosome Potential
Transmembrane473 – 49321Helical; Potential
Topological domain494 – 51926Cytoplasmic Potential

Sites

Metal binding1891Zinc A By similarity
Metal binding2111Zinc A By similarity
Metal binding2201Zinc A By similarity
Metal binding3691Zinc B By similarity
Metal binding3731Zinc B By similarity
Metal binding3961Zinc B By similarity

Amino acid modifications

Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3421N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q4R1H1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: E44F33A8D8CD2292

FASTA51958,573
        10         20         30         40         50         60 
MVPFRWGLLL GCLGSALGPG AQAQFPRVCM TVGSLQAKEC CPPLGAEPSN VCGSLEGRGR 

        70         80         90        100        110        120 
CAEVQADTRP WSGPYVLRNQ DDRERWPRKF FDRTCRCTGN FAGYNCGDCK FGWTGPNCDQ 

       130        140        150        160        170        180 
KKPLVVRQNI HSLTAQEREQ FLGALDLAKN TPHPDYVITT QHWLGLLGPN GTQPQIANCS 

       190        200        210        220        230        240 
IYDLFVWLHY YSVRDTLLGP GRPYKAIDFS HQGPAFVTWH RYHLLWLERA LQRLTGNESF 

       250        260        270        280        290        300 
AVPYWNFATG RNECDVCTDQ LLGAARPDDP TLISQNSRFS SWEIVCDSLD DYNRRVTLCN 

       310        320        330        340        350        360 
GTYEGLLRRN QVGRNSEKLP SLKDIEDCLS LKQFDNPPFF QNSTFSFRNA LEGFDKADGT 

       370        380        390        400        410        420 
LDSQVMSLHN LVHSFLNGTS ALPHSAANDP VFVVLHSFTD AIFDEWMKRF SPPVDAWPQE 

       430        440        450        460        470        480 
LAPIGHNRMY NMVPFFPPVT NEELFLTADQ LGYSYAIDLP VSVEGTPDWT TTLSVVMGML 

       490        500        510 
VVLVGLSALL LFLQYRRLRK GYTPLMETQL SHKRYTEEA 

« Hide

References

[1]"Sequences and mapping of genes encoding porcine tyrosinase (TYR) and tyrosinase-related proteins (TYRP1 and TYRP2)."
Okumura N., Hayashi T., Sekikawa H., Matsumoto T., Mikawa A., Hamasima N., Awata T.
Anim. Genet. 36:513-516(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB207241 mRNA. Translation: BAD99582.1.
RefSeqNP_001020398.1. NM_001025227.1.
UniGeneSsc.42739.

3D structure databases

ProteinModelPortalQ4R1H1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000010135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000010405; ENSSSCP00000010135; ENSSSCG00000009490.
GeneID574066.
KEGGssc:574066.

Organism-specific databases

CTD1638.

Phylogenomic databases

eggNOGNOG301916.
GeneTreeENSGT00500000044790.
HOGENOMHOG000118376.
HOVERGENHBG003553.
KOK01827.
OMAWPRKFFN.
OrthoDBEOG7TJ3HG.
TreeFamTF315865.

Enzyme and pathway databases

UniPathwayUPA00785.

Family and domain databases

Gene3D1.10.1280.10. 1 hit.
InterProIPR002227. Tyrosinase.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSPR00092. TYROSINASE.
SUPFAMSSF48056. SSF48056. 1 hit.
PROSITEPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRP2_PIG
AccessionPrimary (citable) accession number: Q4R1H1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways