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Protein

Alcohol dehydrogenase 2

Gene

ADH2

Organism
Oryza sativa subsp. indica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalyticBy similarity1
Metal bindingi49Zinc 1By similarity1
Binding sitei49NADBy similarity1
Binding sitei49SubstrateBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Binding sitei69SubstrateBy similarity1
Metal bindingi99Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi105Zinc 2By similarity1
Metal bindingi113Zinc 2By similarity1
Metal bindingi177Zinc 1; catalyticBy similarity1
Binding sitei226NADBy similarity1
Binding sitei231NADBy similarity1
Binding sitei272NAD; via carbonyl oxygenBy similarity1
Binding sitei295NAD; via carbonyl oxygenBy similarity1
Binding sitei322NAD; via amide nitrogenBy similarity1
Binding sitei372NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 207NADBy similarity6
Nucleotide bindingi295 – 297NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 2 (EC:1.1.1.1By similarity)
Gene namesi
Name:ADH2
OrganismiOryza sativa subsp. indica (Rice)
Taxonomic identifieri39946 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002914621 – 379Alcohol dehydrogenase 2Add BLAST379

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

STRINGi39946.BGIOSGA034309-PA.

Structurei

3D structure databases

ProteinModelPortaliQ4R1E8.
SMRiQ4R1E8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4R1E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD
60 70 80 90 100
VYFWEAKGQT PVFPRILGHE AGGIVESVGE GVTELAPGDH VLPVFTGECK
110 120 130 140 150
ECDHCKSEES NMCDLLRINV DRGVMIGDGK SRFTIKGKPI FHFVGTSTFS
160 170 180 190 200
EYTVIHVGCL AKINPEAPLD KVCILSCGFS TGFGATVNVA KPKKGQTVAI
210 220 230 240 250
FGLGAVGLAA MEGARLSGAS RIIGVDLNPA KFEQAKKFGC TDFVNPKDHS
260 270 280 290 300
KPVHEVLIEM TNGGLDRAVE CTGNINAMIS CFECVHDGWG VAVLVGVPTK
310 320 330 340 350
DDVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPNVVELYMK KELELEKFIT
360 370
HSVPFSEINT AFDLMLKGES LRCVMRMDE
Length:379
Mass (Da):41,207
Last modified:July 19, 2005 - v1
Checksum:i2DF98CF6B6BEE8EA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4Missing in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti4Missing in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti20 – 21KP → EA in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti20 – 21KP → EA in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti34A → R in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti34A → R in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti87P → A in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti87P → A in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti181 – 182TG → SR in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti181 – 182TG → SR in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti254 – 255HE → Q in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti254 – 255HE → Q in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti298 – 299Missing in CAA34364 (PubMed:2562760).Curated2
Sequence conflicti298 – 299Missing in AAA33889 (PubMed:2332167).Curated2
Sequence conflicti321F → LI in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti321F → LI in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti351Missing in CAA34364 (PubMed:2562760).Curated1
Sequence conflicti351Missing in AAA33889 (PubMed:2332167).Curated1
Sequence conflicti369 – 374ESLRCV → RVSAAS in AAA33889 (PubMed:2332167).Curated6
Sequence conflicti376 – 378RMD → SMY in CAA34364 (PubMed:2562760).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16297 mRNA. Translation: CAA34364.1.
M36469 Genomic DNA. Translation: AAA33889.1.
AB208537 Genomic DNA. Translation: BAE00045.1.
PIRiJH0111. DERZA2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16297 mRNA. Translation: CAA34364.1.
M36469 Genomic DNA. Translation: AAA33889.1.
AB208537 Genomic DNA. Translation: BAE00045.1.
PIRiJH0111. DERZA2.

3D structure databases

ProteinModelPortaliQ4R1E8.
SMRiQ4R1E8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39946.BGIOSGA034309-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH2_ORYSI
AccessioniPrimary (citable) accession number: Q4R1E8
Secondary accession number(s): P18332
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 19, 2005
Last modified: February 15, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.