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Q4R1E8 (ADH2_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 2
EC=1.1.1.1
Gene names
Name:ADH2
OrganismOryza sativa subsp. indica (Rice)
Taxonomic identifier39946 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Alcohol dehydrogenase 2
PRO_0000291462

Regions

Nucleotide binding202 – 2076NAD By similarity
Nucleotide binding295 – 2973NAD By similarity

Sites

Metal binding471Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding991Zinc 2 By similarity
Metal binding1021Zinc 2 By similarity
Metal binding1051Zinc 2 By similarity
Metal binding1131Zinc 2 By similarity
Metal binding1771Zinc 1; catalytic By similarity
Binding site2261NAD By similarity
Binding site2311NAD By similarity
Binding site3721NAD By similarity

Experimental info

Sequence conflict41Missing in CAA34364. Ref.1
Sequence conflict41Missing in AAA33889. Ref.2
Sequence conflict20 – 212KP → EA in CAA34364. Ref.1
Sequence conflict20 – 212KP → EA in AAA33889. Ref.2
Sequence conflict341A → R in CAA34364. Ref.1
Sequence conflict341A → R in AAA33889. Ref.2
Sequence conflict871P → A in CAA34364. Ref.1
Sequence conflict871P → A in AAA33889. Ref.2
Sequence conflict181 – 1822TG → SR in CAA34364. Ref.1
Sequence conflict181 – 1822TG → SR in AAA33889. Ref.2
Sequence conflict254 – 2552HE → Q in CAA34364. Ref.1
Sequence conflict254 – 2552HE → Q in AAA33889. Ref.2
Sequence conflict298 – 2992Missing in CAA34364. Ref.1
Sequence conflict298 – 2992Missing in AAA33889. Ref.2
Sequence conflict3211F → LI in CAA34364. Ref.1
Sequence conflict3211F → LI in AAA33889. Ref.2
Sequence conflict3511Missing in CAA34364. Ref.1
Sequence conflict3511Missing in AAA33889. Ref.2
Sequence conflict369 – 3746ESLRCV → RVSAAS in AAA33889. Ref.2
Sequence conflict376 – 3783RMD → SMY in CAA34364. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q4R1E8 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 2DF98CF6B6BEE8EA

FASTA37941,207
        10         20         30         40         50         60 
MATAGKVIKC KAAVAWEAGK PLSIEEVEVA PPQAMEVRVK ILYTALCHTD VYFWEAKGQT 

        70         80         90        100        110        120 
PVFPRILGHE AGGIVESVGE GVTELAPGDH VLPVFTGECK ECDHCKSEES NMCDLLRINV 

       130        140        150        160        170        180 
DRGVMIGDGK SRFTIKGKPI FHFVGTSTFS EYTVIHVGCL AKINPEAPLD KVCILSCGFS 

       190        200        210        220        230        240 
TGFGATVNVA KPKKGQTVAI FGLGAVGLAA MEGARLSGAS RIIGVDLNPA KFEQAKKFGC 

       250        260        270        280        290        300 
TDFVNPKDHS KPVHEVLIEM TNGGLDRAVE CTGNINAMIS CFECVHDGWG VAVLVGVPTK 

       310        320        330        340        350        360 
DDVFKTHPMN FLNEKTLKGT FFGNYKPRTD LPNVVELYMK KELELEKFIT HSVPFSEINT 

       370 
AFDLMLKGES LRCVMRMDE

« Hide

References

[1]"Rice alcohol dehydrogenase genes: anaerobic induction, organ specific expression and characterization of cDNA clones."
Xie Y., Wu R.
Plant Mol. Biol. 13:53-68(1989) [PubMed: 2562760] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. IR26.
Tissue: Seedling.
[2]"Molecular analysis of an alcohol dehydrogenase-encoding genomic clone (adh2) from rice."
Xie Y., Wu R.
Gene 87:185-191(1990) [PubMed: 2332167] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Nucleotide polymorphism in the Adh2 region of the wild rice Oryza rufipogon."
Yoshida K., Miyashita N.T.
Theor. Appl. Genet. 111:1215-1228(2005) [PubMed: 16133310] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. IR36.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X16297 mRNA. Translation: CAA34364.1.
M36469 Genomic DNA. Translation: AAA33889.1.
AB208537 Genomic DNA. Translation: BAE00045.1.
PIRDERZA2. JH0111.

3D structure databases

HSSPHSSP built from PDB template 1M6H based on UniProtKB P11766.
ProteinModelPortalQ4R1E8.
SMRQ4R1E8. Positions 4-377.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os11g10510.1; LOC_Os11g10510.1; LOC_Os11g10510.

Organism-specific databases

GrameneQ4R1E8.

Family and domain databases

InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 2 hits.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH2_ORYSI
AccessionPrimary (citable) accession number: Q4R1E8
Secondary accession number(s): P18332
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 19, 2005
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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