Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Origin recognition complex subunit 3

Gene

Orc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 3
Gene namesi
Name:Orc3
Synonyms:Orc3l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308457 Orc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003299711 – 711Origin recognition complex subunit 3Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23PhosphoserineBy similarity1
Modified residuei515PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4R180
PRIDEiQ4R180

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011085

Structurei

3D structure databases

SMRiQ4R180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC3 family.Curated

Phylogenomic databases

eggNOGiKOG2538 Eukaryota
ENOG410XT1W LUCA
HOGENOMiHOG000047785
HOVERGENiHBG007599
InParanoidiQ4R180
KOiK02605
PhylomeDBiQ4R180

Family and domain databases

InterProiView protein in InterPro
IPR020795 ORC3
PANTHERiPTHR12748 PTHR12748, 1 hit
PfamiView protein in Pfam
PF07034 ORC3_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q4R180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL
60 70 80 90 100
WQRIKSETEQ LQEGLNENLF DNLVDFLQKS HSEFQKNSGN WGSQMRLREI
110 120 130 140 150
PTAALILGVN VTDHDVIFRS LTETLHNNVT PYVVSLQAKD CPDVKHFLQK
160 170 180 190 200
LTSELIDCCV DRNSKEEKND KALRRTSYSM DSLSSWYSTV AQKTGPKMTS
210 220 230 240 250
KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL HEFPLILIFG
260 270 280 290 300
IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK
310 320 330 340 350
LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA
360 370 380 390 400
KKRINVFSVN QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL
410 420 430 440 450
LEDLHVYHIN YFLVLRCLHN FTSSLPKYPL GRQIRELYCT CLEKKIWDSE
460 470 480 490 500
EYESALQLLR MLAKDELMGI LEQCVKVLNS STEKQLSNTA QKIKGFLTQF
510 520 530 540 550
QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR TTKKPTKFEM
560 570 580 590 600
LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH
610 620 630 640 650
TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE
660 670 680 690 700
AFATVVTAAE KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT
710
DHVARLTWGG C
Length:711
Mass (Da):81,901
Last modified:July 19, 2005 - v1
Checksum:iD5D8B3EB087027AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219142 mRNA Translation: BAE02662.1
RefSeqiNP_001020453.1, NM_001025282.1
UniGeneiRn.162803

Genome annotation databases

GeneIDi313138
KEGGirno:313138
UCSCiRGD:1308457 rat

Similar proteinsi

Entry informationi

Entry nameiORC3_RAT
AccessioniPrimary (citable) accession number: Q4R180
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health