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Q4R180

- ORC3_RAT

UniProt

Q4R180 - ORC3_RAT

Protein

Origin recognition complex subunit 3

Gene

Orc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication By similarity. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Origin recognition complex subunit 3
    Gene namesi
    Name:Orc3
    Synonyms:Orc3l
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1308457. Orc3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nuclear origin of replication recognition complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 711711Origin recognition complex subunit 3PRO_0000329971Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231PhosphoserineBy similarity
    Modified residuei515 – 5151PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4R180.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4R180.

    Interactioni

    Subunit structurei

    Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011085.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORC3 family.Curated

    Phylogenomic databases

    eggNOGiNOG296366.
    HOGENOMiHOG000047785.
    HOVERGENiHBG007599.
    InParanoidiQ4R180.
    KOiK02605.
    PhylomeDBiQ4R180.

    Family and domain databases

    InterProiIPR020795. ORC3.
    [Graphical view]
    PANTHERiPTHR12748. PTHR12748. 1 hit.
    PfamiPF07034. ORC3_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4R180-1 [UniParc]FASTAAdd to Basket

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    MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL    50
    WQRIKSETEQ LQEGLNENLF DNLVDFLQKS HSEFQKNSGN WGSQMRLREI 100
    PTAALILGVN VTDHDVIFRS LTETLHNNVT PYVVSLQAKD CPDVKHFLQK 150
    LTSELIDCCV DRNSKEEKND KALRRTSYSM DSLSSWYSTV AQKTGPKMTS 200
    KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL HEFPLILIFG 250
    IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK 300
    LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA 350
    KKRINVFSVN QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL 400
    LEDLHVYHIN YFLVLRCLHN FTSSLPKYPL GRQIRELYCT CLEKKIWDSE 450
    EYESALQLLR MLAKDELMGI LEQCVKVLNS STEKQLSNTA QKIKGFLTQF 500
    QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR TTKKPTKFEM 550
    LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH 600
    TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE 650
    AFATVVTAAE KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT 700
    DHVARLTWGG C 711
    Length:711
    Mass (Da):81,901
    Last modified:July 19, 2005 - v1
    Checksum:iD5D8B3EB087027AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB219142 mRNA. Translation: BAE02662.1.
    RefSeqiNP_001020453.1. NM_001025282.1.
    UniGeneiRn.162803.

    Genome annotation databases

    GeneIDi313138.
    KEGGirno:313138.
    UCSCiRGD:1308457. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB219142 mRNA. Translation: BAE02662.1 .
    RefSeqi NP_001020453.1. NM_001025282.1.
    UniGenei Rn.162803.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011085.

    Proteomic databases

    PRIDEi Q4R180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 313138.
    KEGGi rno:313138.
    UCSCi RGD:1308457. rat.

    Organism-specific databases

    CTDi 23595.
    RGDi 1308457. Orc3.

    Phylogenomic databases

    eggNOGi NOG296366.
    HOGENOMi HOG000047785.
    HOVERGENi HBG007599.
    InParanoidi Q4R180.
    KOi K02605.
    PhylomeDBi Q4R180.

    Miscellaneous databases

    NextBioi 665703.
    PROi Q4R180.

    Gene expression databases

    Genevestigatori Q4R180.

    Family and domain databases

    InterProi IPR020795. ORC3.
    [Graphical view ]
    PANTHERi PTHR12748. PTHR12748. 1 hit.
    Pfami PF07034. ORC3_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat origin recognition complex, subunit 3."
      Saitoh Y.
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiORC3_RAT
    AccessioniPrimary (citable) accession number: Q4R180
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3