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Q4R180 (ORC3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Origin recognition complex subunit 3
Gene names
Name:Orc3
Synonyms:Orc3l
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length711 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication By similarity. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 By similarity.

Subunit structure

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ORC3 family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentNucleus
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnuclear origin of replication recognition complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 711711Origin recognition complex subunit 3
PRO_0000329971

Amino acid modifications

Modified residue231Phosphoserine By similarity
Modified residue5151Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4R180 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: D5D8B3EB087027AA

FASTA71181,901
        10         20         30         40         50         60 
MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL WQRIKSETEQ 

        70         80         90        100        110        120 
LQEGLNENLF DNLVDFLQKS HSEFQKNSGN WGSQMRLREI PTAALILGVN VTDHDVIFRS 

       130        140        150        160        170        180 
LTETLHNNVT PYVVSLQAKD CPDVKHFLQK LTSELIDCCV DRNSKEEKND KALRRTSYSM 

       190        200        210        220        230        240 
DSLSSWYSTV AQKTGPKMTS KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL 

       250        260        270        280        290        300 
HEFPLILIFG IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK 

       310        320        330        340        350        360 
LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA KKRINVFSVN 

       370        380        390        400        410        420 
QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL LEDLHVYHIN YFLVLRCLHN 

       430        440        450        460        470        480 
FTSSLPKYPL GRQIRELYCT CLEKKIWDSE EYESALQLLR MLAKDELMGI LEQCVKVLNS 

       490        500        510        520        530        540 
STEKQLSNTA QKIKGFLTQF QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR 

       550        560        570        580        590        600 
TTKKPTKFEM LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH 

       610        620        630        640        650        660 
TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE AFATVVTAAE 

       670        680        690        700        710 
KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT DHVARLTWGG C 

« Hide

References

[1]"Rat origin recognition complex, subunit 3."
Saitoh Y.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB219142 mRNA. Translation: BAE02662.1.
RefSeqNP_001020453.1. NM_001025282.1.
UniGeneRn.162803.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011085.

Proteomic databases

PRIDEQ4R180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID313138.
KEGGrno:313138.
UCSCRGD:1308457. rat.

Organism-specific databases

CTD23595.
RGD1308457. Orc3.

Phylogenomic databases

eggNOGNOG296366.
HOGENOMHOG000047785.
HOVERGENHBG007599.
InParanoidQ4R180.
KOK02605.
PhylomeDBQ4R180.

Gene expression databases

GenevestigatorQ4R180.

Family and domain databases

InterProIPR020795. ORC3.
[Graphical view]
PANTHERPTHR12748. PTHR12748. 1 hit.
PfamPF07034. ORC3_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio665703.
PROQ4R180.

Entry information

Entry nameORC3_RAT
AccessionPrimary (citable) accession number: Q4R180
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families