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Protein

Origin recognition complex subunit 3

Gene

Orc3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Origin recognition complex subunit 3
Gene namesi
Name:Orc3
Synonyms:Orc3l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308457. Orc3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Origin recognition complex subunit 3PRO_0000329971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei515 – 5151PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4R180.

Expressioni

Gene expression databases

GenevisibleiQ4R180. RN.

Interactioni

Subunit structurei

Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011085.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORC3 family.Curated

Phylogenomic databases

eggNOGiNOG296366.
HOGENOMiHOG000047785.
HOVERGENiHBG007599.
InParanoidiQ4R180.
KOiK02605.
PhylomeDBiQ4R180.

Family and domain databases

InterProiIPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4R180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSSVSKGC FVFKPDFKKR KISVPIEDYF NNEELDSEDS KLRFETYRLL
60 70 80 90 100
WQRIKSETEQ LQEGLNENLF DNLVDFLQKS HSEFQKNSGN WGSQMRLREI
110 120 130 140 150
PTAALILGVN VTDHDVIFRS LTETLHNNVT PYVVSLQAKD CPDVKHFLQK
160 170 180 190 200
LTSELIDCCV DRNSKEEKND KALRRTSYSM DSLSSWYSTV AQKTGPKMTS
210 220 230 240 250
KKRATCSQWQ SPPVVLILKN MESFSTKVLQ DFIIISSQHL HEFPLILIFG
260 270 280 290 300
IATSPVIIHR LLPHSVSSLL CIELFQSLSC KEHLTVVLDK LLLTPQFPFK
310 320 330 340 350
LSKKALQVLT NIFLYHDFSI QNFIKGLKLS LLEHFYSQPL SVLCCDLSEA
360 370 380 390 400
KKRINVFSVN QCEKIRRLPS FRRYVENQPL EKQVALLTNE TFLKEETQSL
410 420 430 440 450
LEDLHVYHIN YFLVLRCLHN FTSSLPKYPL GRQIRELYCT CLEKKIWDSE
460 470 480 490 500
EYESALQLLR MLAKDELMGI LEQCVKVLNS STEKQLSNTA QKIKGFLTQF
510 520 530 540 550
QNLDDSKEEE DACGSQPKGL QKTDLYHLQK SLLEMKELRR TTKKPTKFEM
560 570 580 590 600
LRENVINFID NLVRDYLLPP EGQPLHEVVY FSAANTLREH LNAAPRIALH
610 620 630 640 650
TALNNPYYYL KNEALKSEEG CIPSVAPDIC IAYKLHLECS RLINLVDWSE
660 670 680 690 700
AFATVVTAAE KMDTNSTVSE EMSEIIHARF IRAVSELELL GFIKPTKQKT
710
DHVARLTWGG C
Length:711
Mass (Da):81,901
Last modified:July 19, 2005 - v1
Checksum:iD5D8B3EB087027AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219142 mRNA. Translation: BAE02662.1.
RefSeqiNP_001020453.1. NM_001025282.1.
UniGeneiRn.162803.

Genome annotation databases

GeneIDi313138.
KEGGirno:313138.
UCSCiRGD:1308457. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB219142 mRNA. Translation: BAE02662.1.
RefSeqiNP_001020453.1. NM_001025282.1.
UniGeneiRn.162803.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011085.

Proteomic databases

PRIDEiQ4R180.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi313138.
KEGGirno:313138.
UCSCiRGD:1308457. rat.

Organism-specific databases

CTDi23595.
RGDi1308457. Orc3.

Phylogenomic databases

eggNOGiNOG296366.
HOGENOMiHOG000047785.
HOVERGENiHBG007599.
InParanoidiQ4R180.
KOiK02605.
PhylomeDBiQ4R180.

Miscellaneous databases

NextBioi665703.
PROiQ4R180.

Gene expression databases

GenevisibleiQ4R180. RN.

Family and domain databases

InterProiIPR020795. ORC3.
[Graphical view]
PANTHERiPTHR12748. PTHR12748. 1 hit.
PfamiPF07034. ORC3_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat origin recognition complex, subunit 3."
    Saitoh Y.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiORC3_RAT
AccessioniPrimary (citable) accession number: Q4R180
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2005
Last modified: June 24, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.