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Q4QY38 (DB134_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 134
Alternative name(s):
Defensin, beta 134
Gene names
Name:DEFB134
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length66 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the beta-defensin family.

Caution

Was termed (Ref.2) DEFB135.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 6647Beta-defensin 134
PRO_0000045360

Amino acid modifications

Disulfide bond32 ↔ 58 By similarity
Disulfide bond38 ↔ 52 By similarity
Disulfide bond42 ↔ 59 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QY38 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: DA47541B373E1990

FASTA667,552
        10         20         30         40         50         60 
MKPLLVVFVF LFLWDPVLAG INSLSSEMHK KCYKNGICRL ECYESEMLVA YCMFQLECCV 


KGNPAP 

« Hide

References

« Hide 'large scale' references
[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
Patil A., Zhang G.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012024 mRNA. Translation: AAY59760.1.
AY621331 mRNA. Translation: AAT51870.1.
BC130461 mRNA. Translation: AAI30462.1.
BC130463 mRNA. Translation: AAI30464.1.
CCDSCCDS34847.1.
RefSeqNP_001028191.1. NM_001033019.1.
UniGeneHs.631852.

3D structure databases

ProteinModelPortalQ4QY38.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371640.

Polymorphism databases

DMDM74762871.

Proteomic databases

PRIDEQ4QY38.

Protocols and materials databases

DNASU613211.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382205; ENSP00000371640; ENSG00000205882.
ENST00000526438; ENSP00000435010; ENSG00000205882.
GeneID613211.
KEGGhsa:613211.
UCSCuc011kxn.2. human.

Organism-specific databases

CTD613211.
GeneCardsGC08M011851.
HGNCHGNC:32399. DEFB134.
HPAHPA044494.
neXtProtNX_Q4QY38.
PharmGKBPA164718735.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG129910.
HOGENOMHOG000112164.
HOVERGENHBG079896.
InParanoidQ4QY38.
OMAFQLECCI.
OrthoDBEOG7DJSQ9.
PhylomeDBQ4QY38.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ4QY38.
GenevestigatorQ4QY38.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio112844.
PROQ4QY38.

Entry information

Entry nameDB134_HUMAN
AccessionPrimary (citable) accession number: Q4QY38
Secondary accession number(s): A1L4A4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2005
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM