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Protein

Beta-defensin 134

Gene

DEFB134

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 134
Alternative name(s):
Defensin, beta 134
Gene namesi
Name:DEFB134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32399. DEFB134.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164718735.

Polymorphism and mutation databases

BioMutaiDEFB134.
DMDMi74762871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 6647Beta-defensin 134PRO_0000045360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 58By similarity
Disulfide bondi38 ↔ 52By similarity
Disulfide bondi42 ↔ 59By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ4QY38.

Expressioni

Gene expression databases

BgeeiQ4QY38.
GenevestigatoriQ4QY38.

Organism-specific databases

HPAiHPA044494.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371640.

Structurei

3D structure databases

ProteinModelPortaliQ4QY38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG129910.
GeneTreeiENSGT00400000024366.
HOGENOMiHOG000112164.
HOVERGENiHBG079896.
InParanoidiQ4QY38.
OMAiFQLECCI.
OrthoDBiEOG7DJSQ9.
PhylomeDBiQ4QY38.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QY38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLVVFVF LFLWDPVLAG INSLSSEMHK KCYKNGICRL ECYESEMLVA
60
YCMFQLECCV KGNPAP
Length:66
Mass (Da):7,552
Last modified:July 19, 2005 - v1
Checksum:iDA47541B373E1990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012024 mRNA. Translation: AAY59760.1.
AY621331 mRNA. Translation: AAT51870.1.
BC130461 mRNA. Translation: AAI30462.1.
BC130463 mRNA. Translation: AAI30464.1.
CCDSiCCDS34847.1.
RefSeqiNP_001289624.1. NM_001302695.1.
UniGeneiHs.631852.
Hs.98232.

Genome annotation databases

EnsembliENST00000382205; ENSP00000371640; ENSG00000205882.
ENST00000526438; ENSP00000435010; ENSG00000205882.
GeneIDi613211.
KEGGihsa:613211.
UCSCiuc011kxn.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012024 mRNA. Translation: AAY59760.1.
AY621331 mRNA. Translation: AAT51870.1.
BC130461 mRNA. Translation: AAI30462.1.
BC130463 mRNA. Translation: AAI30464.1.
CCDSiCCDS34847.1.
RefSeqiNP_001289624.1. NM_001302695.1.
UniGeneiHs.631852.
Hs.98232.

3D structure databases

ProteinModelPortaliQ4QY38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371640.

Polymorphism and mutation databases

BioMutaiDEFB134.
DMDMi74762871.

Proteomic databases

PRIDEiQ4QY38.

Protocols and materials databases

DNASUi613211.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382205; ENSP00000371640; ENSG00000205882.
ENST00000526438; ENSP00000435010; ENSG00000205882.
GeneIDi613211.
KEGGihsa:613211.
UCSCiuc011kxn.2. human.

Organism-specific databases

CTDi613211.
GeneCardsiGC08M011851.
HGNCiHGNC:32399. DEFB134.
HPAiHPA044494.
neXtProtiNX_Q4QY38.
PharmGKBiPA164718735.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG129910.
GeneTreeiENSGT00400000024366.
HOGENOMiHOG000112164.
HOVERGENiHBG079896.
InParanoidiQ4QY38.
OMAiFQLECCI.
OrthoDBiEOG7DJSQ9.
PhylomeDBiQ4QY38.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii613211.
NextBioi112844.
PROiQ4QY38.

Gene expression databases

BgeeiQ4QY38.
GenevestigatoriQ4QY38.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
    Patil A., Zhang G.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiDB134_HUMAN
AccessioniPrimary (citable) accession number: Q4QY38
Secondary accession number(s): A1L4A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2005
Last modified: May 27, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (Ref. 2) DEFB135.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.