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Protein

Beta-defensin 134

Gene

DEFB134

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

Caution

Was termed (Ref. 2) DEFB135.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 134
Alternative name(s):
Defensin, beta 134
Gene namesi
Name:DEFB134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000205882.8
HGNCiHGNC:32399 DEFB134
neXtProtiNX_Q4QY38

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205882
PharmGKBiPA164718735

Polymorphism and mutation databases

BioMutaiDEFB134
DMDMi74762871

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000004536020 – 66Beta-defensin 134Add BLAST47

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 58By similarity
Disulfide bondi38 ↔ 52By similarity
Disulfide bondi42 ↔ 59By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ4QY38
PRIDEiQ4QY38

Expressioni

Gene expression databases

BgeeiENSG00000205882

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000435010

Structurei

3D structure databases

ProteinModelPortaliQ4QY38
SMRiQ4QY38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFD3 Eukaryota
ENOG41118XV LUCA
GeneTreeiENSGT00400000024366
HOGENOMiHOG000112164
HOVERGENiHBG079896
InParanoidiQ4QY38
OMAiFQLECCI
OrthoDBiEOG091G14QD
PhylomeDBiQ4QY38

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QY38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPLLVVFVF LFLWDPVLAG INSLSSEMHK KCYKNGICRL ECYESEMLVA
60
YCMFQLECCV KGNPAP
Length:66
Mass (Da):7,552
Last modified:July 19, 2005 - v1
Checksum:iDA47541B373E1990
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012024 mRNA Translation: AAY59760.1
AY621331 mRNA Translation: AAT51870.1
BC130461 mRNA Translation: AAI30462.1
BC130463 mRNA Translation: AAI30464.1
CCDSiCCDS34847.1
RefSeqiNP_001289624.1, NM_001302695.1
XP_016869213.1, XM_017013724.1
XP_016885980.1, XM_017030491.1
XP_016885981.1, XM_017030492.1
XP_016885982.1, XM_017030493.1
UniGeneiHs.631852
Hs.98232

Genome annotation databases

EnsembliENST00000382205; ENSP00000371640; ENSG00000205882
ENST00000526438; ENSP00000435010; ENSG00000205882
GeneIDi613211
KEGGihsa:105379765
hsa:613211
UCSCiuc011kxn.3 human

Similar proteinsi

Entry informationi

Entry nameiDB134_HUMAN
AccessioniPrimary (citable) accession number: Q4QY38
Secondary accession number(s): A1L4A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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