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Protein

Iron-sulfur cluster assembly 1 homolog, mitochondrial

Gene

isca1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57IronBy similarity1
Metal bindingi121IronBy similarity1
Metal bindingi123IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Alternative name(s):
HESB-like domain-containing protein 2
Iron-sulfur assembly protein IscA
Gene namesi
Name:isca1
Synonyms:hbld2
ORF Names:zgc:114185
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-050626-94. isca1.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12MitochondrionSequence analysisAdd BLAST12
ChainiPRO_000004273913 – 129Iron-sulfur cluster assembly 1 homolog, mitochondrialAdd BLAST117

Proteomic databases

PaxDbiQ4QRC6.

Expressioni

Gene expression databases

BgeeiENSDARG00000051956.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068166.

Structurei

3D structure databases

ProteinModelPortaliQ4QRC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HesB/IscA family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1120. Eukaryota.
COG0316. LUCA.
GeneTreeiENSGT00490000043385.
HOGENOMiHOG000228314.
HOVERGENiHBG081809.
InParanoidiQ4QRC6.
KOiK13628.
OMAiEYTMEYV.
OrthoDBiEOG091G0YHY.
PhylomeDBiQ4QRC6.
TreeFamiTF314956.

Family and domain databases

Gene3Di2.60.300.12. 1 hit.
InterProiIPR000361. FeS_biogenesis.
IPR016092. FeS_cluster_insertion.
IPR017870. FeS_cluster_insertion_CS.
[Graphical view]
PfamiPF01521. Fe-S_biosyn. 1 hit.
[Graphical view]
SUPFAMiSSF89360. SSF89360. 1 hit.
TIGRFAMsiTIGR00049. TIGR00049. 1 hit.
PROSITEiPS01152. HESB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QRC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASIARATV RAVSRRKILS TRAALTLTPS AVNKVKQLLD NKPEYIGLKV
60 70 80 90 100
GVRTRGCNGL TYTLDYTKNK EQSDEEVLQD GVRVFIEKKA QLTLLGTEMD
110 120
FVETKLSSEF VFNNPNIKGT CGCGESFNI
Length:129
Mass (Da):14,248
Last modified:July 19, 2005 - v1
Checksum:iA777E319DB90D249
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097234 mRNA. Translation: AAH97234.1.
RefSeqiNP_001020349.1. NM_001025178.2.
UniGeneiDr.82921.

Genome annotation databases

EnsembliENSDART00000073676; ENSDARP00000068166; ENSDARG00000051956.
GeneIDi573999.
KEGGidre:573999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097234 mRNA. Translation: AAH97234.1.
RefSeqiNP_001020349.1. NM_001025178.2.
UniGeneiDr.82921.

3D structure databases

ProteinModelPortaliQ4QRC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000068166.

Proteomic databases

PaxDbiQ4QRC6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000073676; ENSDARP00000068166; ENSDARG00000051956.
GeneIDi573999.
KEGGidre:573999.

Organism-specific databases

CTDi81689.
ZFINiZDB-GENE-050626-94. isca1.

Phylogenomic databases

eggNOGiKOG1120. Eukaryota.
COG0316. LUCA.
GeneTreeiENSGT00490000043385.
HOGENOMiHOG000228314.
HOVERGENiHBG081809.
InParanoidiQ4QRC6.
KOiK13628.
OMAiEYTMEYV.
OrthoDBiEOG091G0YHY.
PhylomeDBiQ4QRC6.
TreeFamiTF314956.

Miscellaneous databases

PROiQ4QRC6.

Gene expression databases

BgeeiENSDARG00000051956.

Family and domain databases

Gene3Di2.60.300.12. 1 hit.
InterProiIPR000361. FeS_biogenesis.
IPR016092. FeS_cluster_insertion.
IPR017870. FeS_cluster_insertion_CS.
[Graphical view]
PfamiPF01521. Fe-S_biosyn. 1 hit.
[Graphical view]
SUPFAMiSSF89360. SSF89360. 1 hit.
TIGRFAMsiTIGR00049. TIGR00049. 1 hit.
PROSITEiPS01152. HESB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISCA1_DANRE
AccessioniPrimary (citable) accession number: Q4QRC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.