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Protein

Pre-mRNA-splicing factor SYF2

Gene

Syf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SYF2
Gene namesi
Name:Syf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621592. Syf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002503782 – 242Pre-mRNA-splicing factor SYF2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4QRB2.
PRIDEiQ4QRB2.

PTM databases

iPTMnetiQ4QRB2.
PhosphoSitePlusiQ4QRB2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017742.
GenevisibleiQ4QRB2. RN.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with CCNDBP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024271.

Structurei

3D structure databases

ProteinModelPortaliQ4QRB2.
SMRiQ4QRB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 91Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SYF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2609. Eukaryota.
ENOG410XY86. LUCA.
GeneTreeiENSGT00390000017845.
HOGENOMiHOG000190170.
HOVERGENiHBG080129.
InParanoidiQ4QRB2.
KOiK12868.
OMAiEKWERKK.
OrthoDBiEOG091G0MY0.
PhylomeDBiQ4QRB2.
TreeFamiTF313041.

Family and domain databases

InterProiIPR013260. mRNA_splic_SYF2.
[Graphical view]
PANTHERiPTHR13264. PTHR13264. 1 hit.
PfamiPF08231. SYF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QRB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVTEVVVP ADGAEARPLA AEELAAQKRE QRLRKFRELH LKRNEARKLN
60 70 80 90 100
HQEVVEEDKR LKLPANWEAK KARLEWELQE EEKKKECAAR GEDYEKVKLL
110 120 130 140 150
EISAEDAERW ERRKKKKNPD LGFSDYAAAQ LRQYHRLTKQ IKPDMESYER
160 170 180 190 200
QREKHGEDFF PTSNSLLHGT HVPSSEEIDR MVLDLEKQIE KRDKYSRRRP
210 220 230 240
YNDDADIDYI NERNAKFNKK AERFYGKYTA EIKQNLERGT AV
Length:242
Mass (Da):28,712
Last modified:July 19, 2005 - v1
Checksum:iFFCC25142541B847
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → S in AAK53393 (PubMed:12473062).Curated1
Sequence conflicti174S → F in AAK53393 (PubMed:12473062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF366369 mRNA. Translation: AAK53393.1.
BC097289 mRNA. Translation: AAH97289.1.
RefSeqiNP_596908.1. NM_133417.1.
UniGeneiRn.162117.

Genome annotation databases

EnsembliENSRNOT00000091494; ENSRNOP00000072888; ENSRNOG00000060597.
GeneIDi170933.
KEGGirno:170933.
UCSCiRGD:621592. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF366369 mRNA. Translation: AAK53393.1.
BC097289 mRNA. Translation: AAH97289.1.
RefSeqiNP_596908.1. NM_133417.1.
UniGeneiRn.162117.

3D structure databases

ProteinModelPortaliQ4QRB2.
SMRiQ4QRB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024271.

PTM databases

iPTMnetiQ4QRB2.
PhosphoSitePlusiQ4QRB2.

Proteomic databases

PaxDbiQ4QRB2.
PRIDEiQ4QRB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000091494; ENSRNOP00000072888; ENSRNOG00000060597.
GeneIDi170933.
KEGGirno:170933.
UCSCiRGD:621592. rat.

Organism-specific databases

CTDi25949.
RGDi621592. Syf2.

Phylogenomic databases

eggNOGiKOG2609. Eukaryota.
ENOG410XY86. LUCA.
GeneTreeiENSGT00390000017845.
HOGENOMiHOG000190170.
HOVERGENiHBG080129.
InParanoidiQ4QRB2.
KOiK12868.
OMAiEKWERKK.
OrthoDBiEOG091G0MY0.
PhylomeDBiQ4QRB2.
TreeFamiTF313041.

Enzyme and pathway databases

ReactomeiR-RNO-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ4QRB2.

Gene expression databases

BgeeiENSRNOG00000017742.
GenevisibleiQ4QRB2. RN.

Family and domain databases

InterProiIPR013260. mRNA_splic_SYF2.
[Graphical view]
PANTHERiPTHR13264. PTHR13264. 1 hit.
PfamiPF08231. SYF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYF2_RAT
AccessioniPrimary (citable) accession number: Q4QRB2
Secondary accession number(s): Q91Y33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.