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Protein

Pre-mRNA-splicing factor SYF2

Gene

Syf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in pre-mRNA splicing as component of the spliceosome.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-RNO-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor SYF2
Gene namesi
Name:Syf2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621592 Syf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002503782 – 242Pre-mRNA-splicing factor SYF2Add BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki142Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki233Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ4QRB2
PRIDEiQ4QRB2

PTM databases

iPTMnetiQ4QRB2
PhosphoSitePlusiQ4QRB2

Expressioni

Gene expression databases

BgeeiENSRNOG00000060597
GenevisibleiQ4QRB2 RN

Interactioni

Subunit structurei

Identified in the spliceosome C complex. Interacts with CCNDBP1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024271

Structurei

3D structure databases

ProteinModelPortaliQ4QRB2
SMRiQ4QRB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 91Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the SYF2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2609 Eukaryota
ENOG410XY86 LUCA
GeneTreeiENSGT00390000017845
HOGENOMiHOG000190170
HOVERGENiHBG080129
InParanoidiQ4QRB2
KOiK12868
OMAiRRRMHND
OrthoDBiEOG091G0MY0
PhylomeDBiQ4QRB2
TreeFamiTF313041

Family and domain databases

InterProiView protein in InterPro
IPR013260 mRNA_splic_SYF2
PANTHERiPTHR13264 PTHR13264, 1 hit
PfamiView protein in Pfam
PF08231 SYF2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QRB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVTEVVVP ADGAEARPLA AEELAAQKRE QRLRKFRELH LKRNEARKLN
60 70 80 90 100
HQEVVEEDKR LKLPANWEAK KARLEWELQE EEKKKECAAR GEDYEKVKLL
110 120 130 140 150
EISAEDAERW ERRKKKKNPD LGFSDYAAAQ LRQYHRLTKQ IKPDMESYER
160 170 180 190 200
QREKHGEDFF PTSNSLLHGT HVPSSEEIDR MVLDLEKQIE KRDKYSRRRP
210 220 230 240
YNDDADIDYI NERNAKFNKK AERFYGKYTA EIKQNLERGT AV
Length:242
Mass (Da):28,712
Last modified:July 19, 2005 - v1
Checksum:iFFCC25142541B847
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11A → S in AAK53393 (PubMed:12473062).Curated1
Sequence conflicti174S → F in AAK53393 (PubMed:12473062).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF366369 mRNA Translation: AAK53393.1
BC097289 mRNA Translation: AAH97289.1
RefSeqiNP_596908.1, NM_133417.1
UniGeneiRn.162117

Genome annotation databases

EnsembliENSRNOT00000091494; ENSRNOP00000072888; ENSRNOG00000060597
GeneIDi170933
KEGGirno:170933
UCSCiRGD:621592 rat

Similar proteinsi

Entry informationi

Entry nameiSYF2_RAT
AccessioniPrimary (citable) accession number: Q4QRB2
Secondary accession number(s): Q91Y33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome