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Protein

Stimulated by retinoic acid gene 6 protein homolog

Gene

Stra6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).By similarity

GO - Molecular functioni

  • receptor activity Source: RGD
  • vitamin transporter activity Source: RGD

GO - Biological processi

  • retinoic acid metabolic process Source: RGD
  • vitamin A import Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-2453902. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Stimulated by retinoic acid gene 6 protein homolog
Gene namesi
Name:Stra6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1307551. Stra6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence analysisAdd
BLAST
Transmembranei51 – 7121HelicalSequence analysisAdd
BLAST
Topological domaini72 – 9827CytoplasmicSequence analysisAdd
BLAST
Transmembranei99 – 11921HelicalSequence analysisAdd
BLAST
Topological domaini120 – 20485ExtracellularSequence analysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence analysisAdd
BLAST
Topological domaini226 – 29671CytoplasmicSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 3258ExtracellularSequence analysis
Transmembranei326 – 34621HelicalSequence analysisAdd
BLAST
Topological domaini347 – 36216CytoplasmicSequence analysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence analysisAdd
BLAST
Topological domaini384 – 44057ExtracellularSequence analysisAdd
BLAST
Transmembranei441 – 46121HelicalSequence analysisAdd
BLAST
Topological domaini462 – 47514CytoplasmicSequence analysisAdd
BLAST
Transmembranei476 – 49621HelicalSequence analysisAdd
BLAST
Topological domaini497 – 51014ExtracellularSequence analysisAdd
BLAST
Transmembranei511 – 53121HelicalSequence analysisAdd
BLAST
Topological domaini532 – 670139CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Stimulated by retinoic acid gene 6 protein homologPRO_0000311231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi8 – 81N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4QR83.
PRIDEiQ4QR83.

PTM databases

PhosphoSiteiQ4QR83.

Expressioni

Gene expression databases

ExpressionAtlasiQ4QR83. baseline and differential.
GenevisibleiQ4QR83. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011074.

Structurei

3D structure databases

ProteinModelPortaliQ4QR83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYH. Eukaryota.
ENOG410YGRH. LUCA.
GeneTreeiENSGT00390000015272.
HOGENOMiHOG000154441.
HOVERGENiHBG106311.
InParanoidiQ4QR83.
OMAiAIFCWMS.
OrthoDBiEOG7CRTPB.
PhylomeDBiQ4QR83.
TreeFamiTF331851.

Family and domain databases

InterProiIPR026612. STRA6.
[Graphical view]
PANTHERiPTHR21444:SF16. PTHR21444:SF16. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4QR83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQASENGS QTSSGVTDDY SSWYIEEPLG AEEVQPEGVN PLCQPTVPPA
60 70 80 90 100
LHHACLASLS LLALLLLALL VRRRRLWPHC AHCRPGLPSP VDFLAGNRSW
110 120 130 140 150
TVPTAVFVAL FSNLCLLLPD ENPLPFLNRT AASSPDGEPE TSRGPWKLLA
160 170 180 190 200
LLYYPALYYP LAACATAGHR AAYLLGTVLS WVHVSVQVWQ RAECPQDPKI
210 220 230 240 250
YKHYSLLASL PLLLSLGFLS LWYPVQVVQS IRHRTGAGSQ GLQTSYSEKY
260 270 280 290 300
LRALLCPKKL DSCSHPASKR SLLSRAWAFS QHSIYTPEPG FCLPLKLVIS
310 320 330 340 350
ATLTGTATYQ VALLLLVSVV PTVQKVRAGI TTDVSYLLAG FGIVLSEDRQ
360 370 380 390 400
EVVELVKHHL WAVEACYISA LVLSCSLTFL LLIRSLRTHR ANLKALHRGA
410 420 430 440 450
ALDLGPPLQS THPSRQAIVC WMSFSAYQTA FSCLGLLVQQ VIFFLGTTIL
460 470 480 490 500
AFLVFVPLLH GRNLLLLRSL ESTWPFWLTL VLAVILQNIA ANWVFLESHH
510 520 530 540 550
GYPELTNRRM LCVATFLLFP INMLVGAIMA IWRVLLSSLY NTVHLGQMDL
560 570 580 590 600
SLLPQRAASL DPGYHTYRNF LRIEASQSHP GVIAFCALLL HVPSPQPQPP
610 620 630 640 650
LAPQDSLRPA AEEEGMQLLQ TKDLMAKGAG PKGSRSRARW GLAYTLLHNP
660 670
SLQAFRKAAL TSAKANGTQP
Length:670
Mass (Da):73,763
Last modified:July 19, 2005 - v1
Checksum:i4762A19CA3E816A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097373 mRNA. Translation: AAH97373.1.
RefSeqiNP_001025095.1. NM_001029924.1.
UniGeneiRn.12735.

Genome annotation databases

EnsembliENSRNOT00000090588; ENSRNOP00000070968; ENSRNOG00000008312.
GeneIDi363071.
KEGGirno:363071.
UCSCiRGD:1307551. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097373 mRNA. Translation: AAH97373.1.
RefSeqiNP_001025095.1. NM_001029924.1.
UniGeneiRn.12735.

3D structure databases

ProteinModelPortaliQ4QR83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011074.

PTM databases

PhosphoSiteiQ4QR83.

Proteomic databases

PaxDbiQ4QR83.
PRIDEiQ4QR83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090588; ENSRNOP00000070968; ENSRNOG00000008312.
GeneIDi363071.
KEGGirno:363071.
UCSCiRGD:1307551. rat.

Organism-specific databases

CTDi64220.
RGDi1307551. Stra6.

Phylogenomic databases

eggNOGiENOG410IDYH. Eukaryota.
ENOG410YGRH. LUCA.
GeneTreeiENSGT00390000015272.
HOGENOMiHOG000154441.
HOVERGENiHBG106311.
InParanoidiQ4QR83.
OMAiAIFCWMS.
OrthoDBiEOG7CRTPB.
PhylomeDBiQ4QR83.
TreeFamiTF331851.

Enzyme and pathway databases

ReactomeiR-RNO-2453902. The canonical retinoid cycle in rods (twilight vision).

Miscellaneous databases

PROiQ4QR83.

Gene expression databases

ExpressionAtlasiQ4QR83. baseline and differential.
GenevisibleiQ4QR83. RN.

Family and domain databases

InterProiIPR026612. STRA6.
[Graphical view]
PANTHERiPTHR21444:SF16. PTHR21444:SF16. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiSTRA6_RAT
AccessioniPrimary (citable) accession number: Q4QR83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 19, 2005
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.