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Protein

Stimulated by retinoic acid gene 6 protein homolog

Gene

Stra6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity).By similarity

GO - Molecular functioni

  • receptor activity Source: RGD
  • vitamin transporter activity Source: RGD

GO - Biological processi

  • retinoic acid metabolic process Source: RGD
  • vitamin A import Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-2453902. The canonical retinoid cycle in rods (twilight vision).

Names & Taxonomyi

Protein namesi
Recommended name:
Stimulated by retinoic acid gene 6 protein homolog
Gene namesi
Name:Stra6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1307551. Stra6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 50ExtracellularSequence analysisAdd BLAST50
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Topological domaini72 – 98CytoplasmicSequence analysisAdd BLAST27
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Topological domaini120 – 204ExtracellularSequence analysisAdd BLAST85
Transmembranei205 – 225HelicalSequence analysisAdd BLAST21
Topological domaini226 – 296CytoplasmicSequence analysisAdd BLAST71
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 325ExtracellularSequence analysis8
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Topological domaini347 – 362CytoplasmicSequence analysisAdd BLAST16
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384 – 440ExtracellularSequence analysisAdd BLAST57
Transmembranei441 – 461HelicalSequence analysisAdd BLAST21
Topological domaini462 – 475CytoplasmicSequence analysisAdd BLAST14
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Topological domaini497 – 510ExtracellularSequence analysisAdd BLAST14
Transmembranei511 – 531HelicalSequence analysisAdd BLAST21
Topological domaini532 – 670CytoplasmicSequence analysisAdd BLAST139

GO - Cellular componenti

  • integral component of membrane Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112311 – 670Stimulated by retinoic acid gene 6 protein homologAdd BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ4QR83.
PRIDEiQ4QR83.

PTM databases

PhosphoSitePlusiQ4QR83.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008312.
ExpressionAtlasiQ4QR83. baseline and differential.
GenevisibleiQ4QR83. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011074.

Structurei

3D structure databases

ProteinModelPortaliQ4QR83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYH. Eukaryota.
ENOG410YGRH. LUCA.
GeneTreeiENSGT00390000015272.
HOGENOMiHOG000154441.
HOVERGENiHBG106311.
InParanoidiQ4QR83.
OrthoDBiEOG091G05AQ.
PhylomeDBiQ4QR83.
TreeFamiTF331851.

Family and domain databases

InterProiIPR026612. STRA6.
[Graphical view]
PANTHERiPTHR21444:SF16. PTHR21444:SF16. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4QR83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQASENGS QTSSGVTDDY SSWYIEEPLG AEEVQPEGVN PLCQPTVPPA
60 70 80 90 100
LHHACLASLS LLALLLLALL VRRRRLWPHC AHCRPGLPSP VDFLAGNRSW
110 120 130 140 150
TVPTAVFVAL FSNLCLLLPD ENPLPFLNRT AASSPDGEPE TSRGPWKLLA
160 170 180 190 200
LLYYPALYYP LAACATAGHR AAYLLGTVLS WVHVSVQVWQ RAECPQDPKI
210 220 230 240 250
YKHYSLLASL PLLLSLGFLS LWYPVQVVQS IRHRTGAGSQ GLQTSYSEKY
260 270 280 290 300
LRALLCPKKL DSCSHPASKR SLLSRAWAFS QHSIYTPEPG FCLPLKLVIS
310 320 330 340 350
ATLTGTATYQ VALLLLVSVV PTVQKVRAGI TTDVSYLLAG FGIVLSEDRQ
360 370 380 390 400
EVVELVKHHL WAVEACYISA LVLSCSLTFL LLIRSLRTHR ANLKALHRGA
410 420 430 440 450
ALDLGPPLQS THPSRQAIVC WMSFSAYQTA FSCLGLLVQQ VIFFLGTTIL
460 470 480 490 500
AFLVFVPLLH GRNLLLLRSL ESTWPFWLTL VLAVILQNIA ANWVFLESHH
510 520 530 540 550
GYPELTNRRM LCVATFLLFP INMLVGAIMA IWRVLLSSLY NTVHLGQMDL
560 570 580 590 600
SLLPQRAASL DPGYHTYRNF LRIEASQSHP GVIAFCALLL HVPSPQPQPP
610 620 630 640 650
LAPQDSLRPA AEEEGMQLLQ TKDLMAKGAG PKGSRSRARW GLAYTLLHNP
660 670
SLQAFRKAAL TSAKANGTQP
Length:670
Mass (Da):73,763
Last modified:July 19, 2005 - v1
Checksum:i4762A19CA3E816A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097373 mRNA. Translation: AAH97373.1.
RefSeqiNP_001025095.1. NM_001029924.1.
UniGeneiRn.12735.

Genome annotation databases

EnsembliENSRNOT00000090588; ENSRNOP00000070968; ENSRNOG00000008312.
GeneIDi363071.
KEGGirno:363071.
UCSCiRGD:1307551. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097373 mRNA. Translation: AAH97373.1.
RefSeqiNP_001025095.1. NM_001029924.1.
UniGeneiRn.12735.

3D structure databases

ProteinModelPortaliQ4QR83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011074.

PTM databases

PhosphoSitePlusiQ4QR83.

Proteomic databases

PaxDbiQ4QR83.
PRIDEiQ4QR83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000090588; ENSRNOP00000070968; ENSRNOG00000008312.
GeneIDi363071.
KEGGirno:363071.
UCSCiRGD:1307551. rat.

Organism-specific databases

CTDi64220.
RGDi1307551. Stra6.

Phylogenomic databases

eggNOGiENOG410IDYH. Eukaryota.
ENOG410YGRH. LUCA.
GeneTreeiENSGT00390000015272.
HOGENOMiHOG000154441.
HOVERGENiHBG106311.
InParanoidiQ4QR83.
OrthoDBiEOG091G05AQ.
PhylomeDBiQ4QR83.
TreeFamiTF331851.

Enzyme and pathway databases

ReactomeiR-RNO-2453902. The canonical retinoid cycle in rods (twilight vision).

Miscellaneous databases

PROiQ4QR83.

Gene expression databases

BgeeiENSRNOG00000008312.
ExpressionAtlasiQ4QR83. baseline and differential.
GenevisibleiQ4QR83. RN.

Family and domain databases

InterProiIPR026612. STRA6.
[Graphical view]
PANTHERiPTHR21444:SF16. PTHR21444:SF16. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSTRA6_RAT
AccessioniPrimary (citable) accession number: Q4QR83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.