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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061PROSITE-ProRule annotation
Active sitei390 – 3901PROSITE-ProRule annotation
Active sitei450 – 4501PROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiratno-CPVL. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Gene namesi
Name:CPVL
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1563609. Cpvl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 478Probable serine carboxypeptidase CPVLPRO_0000331566
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – ?Sequence analysisPRO_0000331565

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence analysis
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4QR71.
PRIDEiQ4QR71.

PTM databases

PhosphoSiteiQ4QR71.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012196.

Structurei

3D structure databases

ProteinModelPortaliQ4QR71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00790000123063.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ4QR71.
KOiK09645.
OMAiEYAKNDF.
OrthoDBiEOG74XS6J.
PhylomeDBiQ4QR71.
TreeFamiTF354323.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QR71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAQWKVII LLILLMVIPS DGLFHSIYRS ILVAQPFKGN AGQPLFLSPY
60 70 80 90 100
IRTGKIKEGQ RKSMVSPFPG MYDKSYAGYI TVNQTYNSNL FFWFFPARTQ
110 120 130 140 150
PADAPVVLWL QGGPGGSSMF GLFVEHGPYI ITSNMTVLSR DFPWTFSLSM
160 170 180 190 200
LYIDNPVGTG FSFTDHIQGY AIDEDDVAQD LYSALVQFFK LFPEYAKNDF
210 220 230 240 250
YITGESYAGK YVPAIAYYIH SLNPVRRFKI RLKGIALGDA YTDPETIIGG
260 270 280 290 300
YATFLYEVGL LDEQQRRHFR KQCRKCIKYI KEQEWMKAFE VLDELLDGDL
310 320 330 340 350
TAGPSFFQNV TGCTNYYNIL QCTEPEDQSY FSKFLSLPQV RQAIHVGNRN
360 370 380 390 400
FSDGAEVEKY LREDTVKSVK PWLAEIMNYY KVLIYNGQLD IIVAAALTER
410 420 430 440 450
SLMTMDWKGS YAYRRTHKKI WKIFESDDEV AGYVRRVGKF HQVIVRGGGH
460 470
ILPYDQPLRS FDMINRFIYD RGWEPYKL
Length:478
Mass (Da):55,146
Last modified:July 19, 2005 - v1
Checksum:iBA1ED40D3776355C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097471 mRNA. Translation: AAH97471.1.
RefSeqiNP_001025098.1. NM_001029927.1.
XP_008761137.1. XM_008762915.1.
UniGeneiRn.162752.

Genome annotation databases

EnsembliENSRNOT00000012196; ENSRNOP00000012196; ENSRNOG00000009172.
ENSRNOT00000085812; ENSRNOP00000070651; ENSRNOG00000009172.
GeneIDi502774.
KEGGirno:502774.
UCSCiRGD:1563609. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097471 mRNA. Translation: AAH97471.1.
RefSeqiNP_001025098.1. NM_001029927.1.
XP_008761137.1. XM_008762915.1.
UniGeneiRn.162752.

3D structure databases

ProteinModelPortaliQ4QR71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012196.

Protein family/group databases

ESTHERiratno-CPVL. Carboxypeptidase_S10.
MEROPSiS10.003.

PTM databases

PhosphoSiteiQ4QR71.

Proteomic databases

PaxDbiQ4QR71.
PRIDEiQ4QR71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012196; ENSRNOP00000012196; ENSRNOG00000009172.
ENSRNOT00000085812; ENSRNOP00000070651; ENSRNOG00000009172.
GeneIDi502774.
KEGGirno:502774.
UCSCiRGD:1563609. rat.

Organism-specific databases

CTDi54504.
RGDi1563609. Cpvl.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00790000123063.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ4QR71.
KOiK09645.
OMAiEYAKNDF.
OrthoDBiEOG74XS6J.
PhylomeDBiQ4QR71.
TreeFamiTF354323.

Miscellaneous databases

NextBioi712421.
PROiQ4QR71.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiCPVL_RAT
AccessioniPrimary (citable) accession number: Q4QR71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.