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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei206PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei450PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiratno-CPVL Carboxypeptidase_S10
MEROPSiS10.003

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Gene namesi
Name:CPVL
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi1563609 Cpvl

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000331566? – 478Probable serine carboxypeptidase CPVL
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000033156523 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4QR71
PRIDEiQ4QR71

PTM databases

PhosphoSitePlusiQ4QR71

Expressioni

Gene expression databases

BgeeiENSRNOG00000009172

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012196

Structurei

3D structure databases

ProteinModelPortaliQ4QR71
SMRiQ4QR71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
GeneTreeiENSGT00880000137977
HOGENOMiHOG000252949
HOVERGENiHBG010805
InParanoidiQ4QR71
KOiK09645
OMAiMDNALPR
OrthoDBiEOG091G08SS
PhylomeDBiQ4QR71
TreeFamiTF354323

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QR71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAQWKVII LLILLMVIPS DGLFHSIYRS ILVAQPFKGN AGQPLFLSPY
60 70 80 90 100
IRTGKIKEGQ RKSMVSPFPG MYDKSYAGYI TVNQTYNSNL FFWFFPARTQ
110 120 130 140 150
PADAPVVLWL QGGPGGSSMF GLFVEHGPYI ITSNMTVLSR DFPWTFSLSM
160 170 180 190 200
LYIDNPVGTG FSFTDHIQGY AIDEDDVAQD LYSALVQFFK LFPEYAKNDF
210 220 230 240 250
YITGESYAGK YVPAIAYYIH SLNPVRRFKI RLKGIALGDA YTDPETIIGG
260 270 280 290 300
YATFLYEVGL LDEQQRRHFR KQCRKCIKYI KEQEWMKAFE VLDELLDGDL
310 320 330 340 350
TAGPSFFQNV TGCTNYYNIL QCTEPEDQSY FSKFLSLPQV RQAIHVGNRN
360 370 380 390 400
FSDGAEVEKY LREDTVKSVK PWLAEIMNYY KVLIYNGQLD IIVAAALTER
410 420 430 440 450
SLMTMDWKGS YAYRRTHKKI WKIFESDDEV AGYVRRVGKF HQVIVRGGGH
460 470
ILPYDQPLRS FDMINRFIYD RGWEPYKL
Length:478
Mass (Da):55,146
Last modified:July 19, 2005 - v1
Checksum:iBA1ED40D3776355C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097471 mRNA Translation: AAH97471.1
RefSeqiNP_001025098.1, NM_001029927.1
XP_008761137.1, XM_008762915.2
UniGeneiRn.162752

Genome annotation databases

EnsembliENSRNOT00000012196; ENSRNOP00000012196; ENSRNOG00000009172
ENSRNOT00000085812; ENSRNOP00000070651; ENSRNOG00000009172
GeneIDi502774
KEGGirno:502774
UCSCiRGD:1563609 rat

Entry informationi

Entry nameiCPVL_RAT
AccessioniPrimary (citable) accession number: Q4QR71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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