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Protein

Probable serine carboxypeptidase CPVL

Gene

CPVL

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei206PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei450PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiratno-CPVL. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Gene namesi
Name:CPVL
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1563609. Cpvl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000331566? – 478Probable serine carboxypeptidase CPVL
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000033156523 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ4QR71.
PRIDEiQ4QR71.

PTM databases

PhosphoSitePlusiQ4QR71.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009172.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012196.

Structurei

3D structure databases

ProteinModelPortaliQ4QR71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ4QR71.
KOiK09645.
OMAiEYAKNDF.
OrthoDBiEOG091G08SS.
PhylomeDBiQ4QR71.
TreeFamiTF354323.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QR71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRAQWKVII LLILLMVIPS DGLFHSIYRS ILVAQPFKGN AGQPLFLSPY
60 70 80 90 100
IRTGKIKEGQ RKSMVSPFPG MYDKSYAGYI TVNQTYNSNL FFWFFPARTQ
110 120 130 140 150
PADAPVVLWL QGGPGGSSMF GLFVEHGPYI ITSNMTVLSR DFPWTFSLSM
160 170 180 190 200
LYIDNPVGTG FSFTDHIQGY AIDEDDVAQD LYSALVQFFK LFPEYAKNDF
210 220 230 240 250
YITGESYAGK YVPAIAYYIH SLNPVRRFKI RLKGIALGDA YTDPETIIGG
260 270 280 290 300
YATFLYEVGL LDEQQRRHFR KQCRKCIKYI KEQEWMKAFE VLDELLDGDL
310 320 330 340 350
TAGPSFFQNV TGCTNYYNIL QCTEPEDQSY FSKFLSLPQV RQAIHVGNRN
360 370 380 390 400
FSDGAEVEKY LREDTVKSVK PWLAEIMNYY KVLIYNGQLD IIVAAALTER
410 420 430 440 450
SLMTMDWKGS YAYRRTHKKI WKIFESDDEV AGYVRRVGKF HQVIVRGGGH
460 470
ILPYDQPLRS FDMINRFIYD RGWEPYKL
Length:478
Mass (Da):55,146
Last modified:July 19, 2005 - v1
Checksum:iBA1ED40D3776355C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097471 mRNA. Translation: AAH97471.1.
RefSeqiNP_001025098.1. NM_001029927.1.
XP_008761137.1. XM_008762915.2.
UniGeneiRn.162752.

Genome annotation databases

EnsembliENSRNOT00000012196; ENSRNOP00000012196; ENSRNOG00000009172.
ENSRNOT00000085812; ENSRNOP00000070651; ENSRNOG00000009172.
GeneIDi502774.
KEGGirno:502774.
UCSCiRGD:1563609. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097471 mRNA. Translation: AAH97471.1.
RefSeqiNP_001025098.1. NM_001029927.1.
XP_008761137.1. XM_008762915.2.
UniGeneiRn.162752.

3D structure databases

ProteinModelPortaliQ4QR71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012196.

Protein family/group databases

ESTHERiratno-CPVL. Carboxypeptidase_S10.
MEROPSiS10.003.

PTM databases

PhosphoSitePlusiQ4QR71.

Proteomic databases

PaxDbiQ4QR71.
PRIDEiQ4QR71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012196; ENSRNOP00000012196; ENSRNOG00000009172.
ENSRNOT00000085812; ENSRNOP00000070651; ENSRNOG00000009172.
GeneIDi502774.
KEGGirno:502774.
UCSCiRGD:1563609. rat.

Organism-specific databases

CTDi54504.
RGDi1563609. Cpvl.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ4QR71.
KOiK09645.
OMAiEYAKNDF.
OrthoDBiEOG091G08SS.
PhylomeDBiQ4QR71.
TreeFamiTF354323.

Miscellaneous databases

PROiQ4QR71.

Gene expression databases

BgeeiENSRNOG00000009172.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPVL_RAT
AccessioniPrimary (citable) accession number: Q4QR71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.