Reviewed, UniProtKB/Swiss-Prot Q4QQW4 (HDAC1_RAT)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 1
      Short name=HD1
    EC=3.5.1.98

Gene names

Name:

Hdac1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subunit structure	Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, NFE4, PCAF, PHB2, MIER1, KDM4A, MINT, NRIP1, PRDM6, RERE, SETDB1, SUV39H1, TGIF, TGIF2, UHRF1, UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with BANP, CBFA2T3 and KDM5B. Interacts with E4F1 and KLF1 By similarity.
Subcellular location	Nucleus By similarity.
Post-translational modification	Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1 By similarity. Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes By similarity.
Sequence similarities	Belongs to the histone deacetylase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
PTM	Isopeptide bond Phosphoprotein Ubl conjugation
Gene Ontology (GO)
Biological process	cellular response to oxidative stress Inferred from direct assay. Source: RGD histone deacetylation Inferred from electronic annotation. Source: InterPro negative regulation of cell proliferation Inferred from direct assay. Source: RGD negative regulation of neuron apoptosis Inferred from mutant phenotype. Source: RGD negative regulation of transcription Inferred from direct assay. Source: RGD regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to drug Inferred from expression pattern. Source: RGD transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromatin Inferred from direct assay. Source: RGD nucleus Inferred from direct assay. Source: RGD protein complex Inferred from direct assay. Source: RGD
Molecular function	histone deacetylase activity Inferred from electronic annotation. Source: InterPro protein complex binding Inferred from direct assay. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	Histone deacetylase 1		PRO_0000304731
Regions
	Region	9 – 321	313	Histone deacetylase
Sites
	Active site	141	1	By similarity
Amino acid modifications
	Modified residue	221	1	Phosphotyrosine By similarity
	Modified residue	393	1	Phosphoserine By similarity
	Modified residue	421	1	Phosphoserine By similarity
	Modified residue	423	1	Phosphoserine By similarity
	Cross-link	444		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
	Cross-link	476		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QQW4-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 7F6563C17F5E4844	FASTA	482	55,093
	10 20 30 40 50 60 MAQTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN 70 80 90 100 110 120 AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSTGGSVAS 130 140 150 160 170 180 AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG 190 200 210 220 230 240 DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI 250 260 270 280 290 300 FKPVMSKVME MFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG 310 320 330 340 350 360 GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE 370 380 390 400 410 420 KIKQRLFENL RMLPHAPGVQ MQAIPEDAIP EESGDEDEED PDKRISICSS DKRIACEEEF 430 440 450 460 470 480 SDSDEEGEGG RKNSSNFKKA KRVKTEDEKE KDPEEKKEVT EEEKTKEEKP EAKGVKEEVK MA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC097943 mRNA. Translation: AAH97943.1. BC107476 mRNA. Translation: AAI07477.1.
IPI	IPI00364813.
RefSeq	NP_001020580.1.
UniGene	Rn.1863
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q4QQW4.
Genome annotation databases
Ensembl	ENSRNOG00000009568. Rattus norvegicus. [Contig view]
GeneID	297893.
KEGG	rno:297893.
NMPDR	fig|10116.3.peg.24004.
Organism-specific databases
RGD	619975. Hdac1.
Phylogenomic databases
HOVERGEN	Q4QQW4.
Gene expression databases
ArrayExpress	Q4QQW4.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR003084. His_deacetylse_1. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit. PTHR10625:SF28. His_deacetylse_1. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PIRSF	PIRSF037913. His_deacetylse_1. 1 hit.
PRINTS	PR01270. HDASUPER. PR01271. HISDACETLASE.
ProtoNet	Search...
Other Resources
NextBio	642799.

Entry information

Entry name

HDAC1_RAT

Accession

Primary (citable) accession number: Q4QQW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)