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Protein
Submitted name:

CD40 molecule

Gene

Cd40

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • antigen binding Source: RGD
  • enzyme binding Source: RGD
  • protein domain specific binding Source: RGD
  • tumor necrosis factor-activated receptor activity Source: GO_Central
  • ubiquitin protein ligase binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-RNO-5668541 TNFR2 non-canonical NF-kB pathway
R-RNO-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Names & Taxonomyi

Protein namesi
Submitted name:
CD40 moleculeImported
Submitted name:
CD40 molecule, TNF receptor superfamily member 5Imported
Submitted name:
Tumor necrosis factor receptor superfamily, member 5, isoform CRA_aImported
Gene namesi
Name:Cd40Imported
Synonyms:Tnfrsf5Imported
ORF Names:rCG_32260Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619830 Cd40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei194 – 215HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501430940424 – 289Sequence analysisAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 51PROSITE-ProRule annotation
Disulfide bondi41 ↔ 59PROSITE-ProRule annotation
Disulfide bondi62 ↔ 77PROSITE-ProRule annotation
Disulfide bondi125 ↔ 143PROSITE-ProRule annotation
Disulfide bondi146 ↔ 161PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSRNOG00000018488

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • protein domain specific binding Source: RGD
  • ubiquitin protein ligase binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052022

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 59TNFR-CysInterPro annotationAdd BLAST35
Repeati25 – 59TNFR-CysPROSITE-ProRule annotationAdd BLAST35
Domaini61 – 103TNFR-CysInterPro annotationAdd BLAST43
Repeati61 – 103TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini104 – 143TNFR-CysInterPro annotationAdd BLAST40
Repeati104 – 143TNFR-CysPROSITE-ProRule annotationAdd BLAST40
Domaini145 – 186TNFR-CysInterPro annotationAdd BLAST42
Repeati145 – 186TNFR-CysPROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IY0H Eukaryota
ENOG4112DB5 LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000136317
HOVERGENiHBG005117
KOiK03160
OMAiCHPWTSC
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

CDDicd13407 TNFRSF5, 1 hit
InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020435 TNFR_5
IPR034021 TNFRSF5_N
PfamiView protein in Pfam
PF00020 TNFR_c6, 3 hits
PRINTSiPR01922 TNFACTORR5
SMARTiView protein in SMART
SM00208 TNFR, 4 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 4 hits

Sequencei

Sequence statusi: Complete.

Q4QQW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPQLCAL WGCLLTAVHL GQCVTCSDKQ YLQGGECCDL CQPGNRLVSH
60 70 80 90 100
CTALEKTQCQ PCDSGEFSAH WNREIRCHQH RHCELNQGLQ VKKEGTAVSD
110 120 130 140 150
TVCTCKEGQH CASKECETCA QHTPCGPGFG VVQMATETTD TVCQPCPVGF
160 170 180 190 200
FSNGSSLFEK CHPWTSCEDQ KLMVLREGTS QTDTLCGFQP RMRALLVIPV
210 220 230 240 250
VMVILITIFV VFLYIKKVVK KPKDNEVLPP EARGQDPVEI EDYPGHNTAA
260 270 280
PVQETLHGCQ PVAQEDGKES RISVQERQVT GSMALKPLV
Length:289
Mass (Da):31,801
Last modified:July 19, 2005 - v1
Checksum:i7BFABA76182357AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054571 Genomic DNA No translation available.
BC097949 mRNA Translation: AAH97949.1
CH474005 Genomic DNA Translation: EDL96468.1
RefSeqiNP_599187.1, NM_134360.1
UniGeneiRn.25180

Genome annotation databases

EnsembliENSRNOT00000055148; ENSRNOP00000052022; ENSRNOG00000018488
GeneIDi171369
KEGGirno:171369

Similar proteinsi

Entry informationi

Entry nameiQ4QQW2_RAT
AccessioniPrimary (citable) accession number: Q4QQW2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health