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Protein
Submitted name:

CD40 molecule, TNF receptor superfamily member 5

Gene

Cd40

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: RGD
  • protein domain specific binding Source: RGD
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
CD40 molecule, TNF receptor superfamily member 5Imported
Submitted name:
Protein Cd40Imported
Submitted name:
Tumor necrosis factor receptor superfamily, member 5, isoform CRA_aImported
Gene namesi
Name:Cd40Imported
Synonyms:Tnfrsf5Imported
ORF Names:rCG_32260Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi619830. Cd40.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei194 – 215HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

  • CD40 receptor complex Source: Ensembl
  • cell surface Source: RGD
  • cytoplasm Source: RGD
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: Ensembl
  • extracellular space Source: RGD
  • intracellular membrane-bounded organelle Source: Ensembl
  • neuronal cell body Source: RGD
  • varicosity Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500878055224 – 289Sequence analysisAdd BLAST266

Expressioni

Gene expression databases

BgeeiENSRNOG00000018488.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052022.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 59TNFR-CysInterPro annotationAdd BLAST35
Domaini61 – 103TNFR-CysInterPro annotationAdd BLAST43
Domaini104 – 143TNFR-CysInterPro annotationAdd BLAST40
Domaini145 – 186TNFR-CysInterPro annotationAdd BLAST42

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
KOiK03160.
OMAiEKCHPWT.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPQLCAL WGCLLTAVHL GQCVTCSDKQ YLQGGECCDL CQPGNRLVSH
60 70 80 90 100
CTALEKTQCQ PCDSGEFSAH WNREIRCHQH RHCELNQGLQ VKKEGTAVSD
110 120 130 140 150
TVCTCKEGQH CASKECETCA QHTPCGPGFG VVQMATETTD TVCQPCPVGF
160 170 180 190 200
FSNGSSLFEK CHPWTSCEDQ KLMVLREGTS QTDTLCGFQP RMRALLVIPV
210 220 230 240 250
VMVILITIFV VFLYIKKVVK KPKDNEVLPP EARGQDPVEI EDYPGHNTAA
260 270 280
PVQETLHGCQ PVAQEDGKES RISVQERQVT GSMALKPLV
Length:289
Mass (Da):31,801
Last modified:July 19, 2005 - v1
Checksum:i7BFABA76182357AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054571 Genomic DNA. No translation available.
BC097949 mRNA. Translation: AAH97949.1.
CH474005 Genomic DNA. Translation: EDL96468.1.
RefSeqiNP_599187.1. NM_134360.1.
UniGeneiRn.25180.

Genome annotation databases

EnsembliENSRNOT00000055148; ENSRNOP00000052022; ENSRNOG00000018488.
GeneIDi171369.
KEGGirno:171369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07054571 Genomic DNA. No translation available.
BC097949 mRNA. Translation: AAH97949.1.
CH474005 Genomic DNA. Translation: EDL96468.1.
RefSeqiNP_599187.1. NM_134360.1.
UniGeneiRn.25180.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000052022.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055148; ENSRNOP00000052022; ENSRNOG00000018488.
GeneIDi171369.
KEGGirno:171369.

Organism-specific databases

CTDi958.
RGDi619830. Cd40.

Phylogenomic databases

eggNOGiENOG410IY0H. Eukaryota.
ENOG4112DB5. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000136317.
HOVERGENiHBG005117.
KOiK03160.
OMAiEKCHPWT.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.

Gene expression databases

BgeeiENSRNOG00000018488.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020435. TNFR_5.
[Graphical view]
PfamiPF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01922. TNFACTORR5.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ4QQW2_RAT
AccessioniPrimary (citable) accession number: Q4QQW2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.