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Q4QQW1

- REEP4_RAT

UniProt

Q4QQW1 - REEP4_RAT

Protein

Receptor expression-enhancing protein 4

Gene

Reep4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
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    Functioni

    Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes By similarity.By similarity

    GO - Molecular functioni

    1. microtubule binding Source: UniProtKB

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. mitotic nuclear envelope reassembly Source: UniProtKB
    3. nuclear envelope organization Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor expression-enhancing protein 4
    Gene namesi
    Name:Reep4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 15

    Organism-specific databases

    RGDi1306561. Reep4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. microtubule Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257Receptor expression-enhancing protein 4PRO_0000101833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei152 – 1521PhosphoserineBy similarity
    Modified residuei194 – 1941PhosphoserineBy similarity
    Modified residuei196 – 1961PhosphothreonineBy similarity
    Modified residuei202 – 2021PhosphoserineBy similarity
    Modified residuei250 – 2501PhosphothreonineBy similarity
    Modified residuei253 – 2531PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ4QQW1.

    PTM databases

    PhosphoSiteiQ4QQW1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ4QQW1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015169.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DP1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5052.
    GeneTreeiENSGT00550000074535.
    HOGENOMiHOG000007472.
    HOVERGENiHBG056861.
    InParanoidiQ4QQW1.
    KOiK17338.
    OMAiTYQDPLY.
    OrthoDBiEOG71RXJX.
    PhylomeDBiQ4QQW1.
    TreeFamiTF314177.

    Family and domain databases

    InterProiIPR004345. TB2_DP1_HVA22.
    [Graphical view]
    PANTHERiPTHR12300. PTHR12300. 1 hit.
    PfamiPF03134. TB2_DP1_HVA22. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q4QQW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSWMICRLV VLIFGMLYPA YASYKAVKSK NIREYVRWMM YWIVFAIFMA    50
    AETFTDIFIS WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE 100
    KEIDACIVQA KERSYETMLS FGKRSLNMAA SAAVQAATKS QGALAGRLRS 150
    FSMQDLRSIP DTSAPTYQDP LYLEDQAPRR RPPIGYRPGG LQDSDTEDEC 200
    WSDNEIAPQP PVRPREKPLS RSQSLRVVKR KPLVREGTSR SLKVRTRKKT 250
    IPSDLDS 257
    Length:257
    Mass (Da):29,660
    Last modified:July 19, 2005 - v1
    Checksum:i4F7A370129800F13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097957 mRNA. Translation: AAH97957.1.
    RefSeqiNP_001020450.1. NM_001025279.1.
    UniGeneiRn.6988.

    Genome annotation databases

    EnsembliENSRNOT00000015169; ENSRNOP00000015169; ENSRNOG00000011373.
    GeneIDi306014.
    KEGGirno:306014.
    UCSCiRGD:1306561. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC097957 mRNA. Translation: AAH97957.1 .
    RefSeqi NP_001020450.1. NM_001025279.1.
    UniGenei Rn.6988.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015169.

    PTM databases

    PhosphoSitei Q4QQW1.

    Proteomic databases

    PRIDEi Q4QQW1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000015169 ; ENSRNOP00000015169 ; ENSRNOG00000011373 .
    GeneIDi 306014.
    KEGGi rno:306014.
    UCSCi RGD:1306561. rat.

    Organism-specific databases

    CTDi 80346.
    RGDi 1306561. Reep4.

    Phylogenomic databases

    eggNOGi COG5052.
    GeneTreei ENSGT00550000074535.
    HOGENOMi HOG000007472.
    HOVERGENi HBG056861.
    InParanoidi Q4QQW1.
    KOi K17338.
    OMAi TYQDPLY.
    OrthoDBi EOG71RXJX.
    PhylomeDBi Q4QQW1.
    TreeFami TF314177.

    Miscellaneous databases

    NextBioi 655414.
    PROi Q4QQW1.

    Gene expression databases

    Genevestigatori Q4QQW1.

    Family and domain databases

    InterProi IPR004345. TB2_DP1_HVA22.
    [Graphical view ]
    PANTHERi PTHR12300. PTHR12300. 1 hit.
    Pfami PF03134. TB2_DP1_HVA22. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."
      Moser K., White F.M.
      J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiREEP4_RAT
    AccessioniPrimary (citable) accession number: Q4QQW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3