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Protein

Receptor expression-enhancing protein 4

Gene

Reep4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 4
Gene namesi
Name:Reep4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1306561. Reep4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001018331 – 257Receptor expression-enhancing protein 4Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphoserineCombined sources1
Modified residuei194PhosphoserineBy similarity1
Modified residuei196PhosphothreonineBy similarity1
Modified residuei202PhosphoserineBy similarity1
Modified residuei250PhosphothreonineBy similarity1
Modified residuei253PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ4QQW1.
PRIDEiQ4QQW1.

PTM databases

iPTMnetiQ4QQW1.
PhosphoSitePlusiQ4QQW1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000011373.
GenevisibleiQ4QQW1. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015169.

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1726. Eukaryota.
COG5052. LUCA.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000007472.
HOVERGENiHBG056861.
InParanoidiQ4QQW1.
KOiK17338.
OMAiIDSYIVQ.
OrthoDBiEOG091G0X58.
PhylomeDBiQ4QQW1.
TreeFamiTF314177.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSWMICRLV VLIFGMLYPA YASYKAVKSK NIREYVRWMM YWIVFAIFMA
60 70 80 90 100
AETFTDIFIS WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE
110 120 130 140 150
KEIDACIVQA KERSYETMLS FGKRSLNMAA SAAVQAATKS QGALAGRLRS
160 170 180 190 200
FSMQDLRSIP DTSAPTYQDP LYLEDQAPRR RPPIGYRPGG LQDSDTEDEC
210 220 230 240 250
WSDNEIAPQP PVRPREKPLS RSQSLRVVKR KPLVREGTSR SLKVRTRKKT

IPSDLDS
Length:257
Mass (Da):29,660
Last modified:July 19, 2005 - v1
Checksum:i4F7A370129800F13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097957 mRNA. Translation: AAH97957.1.
RefSeqiNP_001020450.1. NM_001025279.1.
UniGeneiRn.6988.

Genome annotation databases

EnsembliENSRNOT00000015169; ENSRNOP00000015169; ENSRNOG00000011373.
GeneIDi306014.
KEGGirno:306014.
UCSCiRGD:1306561. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097957 mRNA. Translation: AAH97957.1.
RefSeqiNP_001020450.1. NM_001025279.1.
UniGeneiRn.6988.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015169.

PTM databases

iPTMnetiQ4QQW1.
PhosphoSitePlusiQ4QQW1.

Proteomic databases

PaxDbiQ4QQW1.
PRIDEiQ4QQW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015169; ENSRNOP00000015169; ENSRNOG00000011373.
GeneIDi306014.
KEGGirno:306014.
UCSCiRGD:1306561. rat.

Organism-specific databases

CTDi80346.
RGDi1306561. Reep4.

Phylogenomic databases

eggNOGiKOG1726. Eukaryota.
COG5052. LUCA.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000007472.
HOVERGENiHBG056861.
InParanoidiQ4QQW1.
KOiK17338.
OMAiIDSYIVQ.
OrthoDBiEOG091G0X58.
PhylomeDBiQ4QQW1.
TreeFamiTF314177.

Miscellaneous databases

PROiQ4QQW1.

Gene expression databases

BgeeiENSRNOG00000011373.
GenevisibleiQ4QQW1. RN.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREEP4_RAT
AccessioniPrimary (citable) accession number: Q4QQW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.