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Q4QQW1 (REEP4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor expression-enhancing protein 4
Gene names
Name:Reep4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the DP1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 257257Receptor expression-enhancing protein 4
PRO_0000101833

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane42 – 6221Helical; Potential

Amino acid modifications

Modified residue1521Phosphoserine By similarity
Modified residue1941Phosphoserine By similarity
Modified residue1961Phosphothreonine By similarity
Modified residue2021Phosphoserine By similarity
Modified residue2501Phosphothreonine By similarity
Modified residue2531Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q4QQW1 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 4F7A370129800F13

FASTA25729,660
        10         20         30         40         50         60 
MVSWMICRLV VLIFGMLYPA YASYKAVKSK NIREYVRWMM YWIVFAIFMA AETFTDIFIS 

        70         80         90        100        110        120 
WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDACIVQA KERSYETMLS 

       130        140        150        160        170        180 
FGKRSLNMAA SAAVQAATKS QGALAGRLRS FSMQDLRSIP DTSAPTYQDP LYLEDQAPRR 

       190        200        210        220        230        240 
RPPIGYRPGG LQDSDTEDEC WSDNEIAPQP PVRPREKPLS RSQSLRVVKR KPLVREGTSR 

       250 
SLKVRTRKKT IPSDLDS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."
Moser K., White F.M.
J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC097957 mRNA. Translation: AAH97957.1.
RefSeqNP_001020450.1. NM_001025279.1.
UniGeneRn.6988.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000015169.

PTM databases

PhosphoSiteQ4QQW1.

Proteomic databases

PRIDEQ4QQW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000015169; ENSRNOP00000015169; ENSRNOG00000011373.
GeneID306014.
KEGGrno:306014.
UCSCRGD:1306561. rat.

Organism-specific databases

CTD80346.
RGD1306561. Reep4.

Phylogenomic databases

eggNOGCOG5052.
GeneTreeENSGT00550000074535.
HOGENOMHOG000007472.
HOVERGENHBG056861.
InParanoidQ4QQW1.
KOK17338.
OMAYLEDQVP.
OrthoDBEOG71RXJX.
PhylomeDBQ4QQW1.
TreeFamTF314177.

Gene expression databases

GenevestigatorQ4QQW1.

Family and domain databases

InterProIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERPTHR12300. PTHR12300. 1 hit.
PfamPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio655414.
PROQ4QQW1.

Entry information

Entry nameREEP4_RAT
AccessionPrimary (citable) accession number: Q4QQW1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2005
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families