Q4QQW1 (REEP4_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor expression-enhancing protein 4

Gene names

Name:

Reep4

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May enhance the cell surface expression of odorant receptors By similarity.
Subunit structure	Interacts with odorant receptor proteins By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the DP1 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Receptor expression-enhancing protein 4		PRO_0000101833
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	42 – 62	21	Helical; Potential
Amino acid modifications
	Modified residue	152	1	Phosphoserine By similarity
	Modified residue	194	1	Phosphoserine By similarity
	Modified residue	196	1	Phosphothreonine By similarity
	Modified residue	202	1	Phosphoserine By similarity
	Modified residue	250	1	Phosphothreonine By similarity
	Modified residue	253	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QQW1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 4F7A370129800F13	FASTA	257	29,660
	10 20 30 40 50 60 MVSWMICRLV VLIFGMLYPA YASYKAVKSK NIREYVRWMM YWIVFAIFMA AETFTDIFIS 70 80 90 100 110 120 WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE KEIDACIVQA KERSYETMLS 130 140 150 160 170 180 FGKRSLNMAA SAAVQAATKS QGALAGRLRS FSMQDLRSIP DTSAPTYQDP LYLEDQAPRR 190 200 210 220 230 240 RPPIGYRPGG LQDSDTEDEC WSDNEIAPQP PVRPREKPLS RSQSLRVVKR KPLVREGTSR 250 SLKVRTRKKT IPSDLDS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC097957 mRNA. Translation: AAH97957.1.
IPI	IPI00373271.
RefSeq	NP_001020450.1. NM_001025279.1.
UniGene	Rn.6988.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000015169.
PTM databases
PhosphoSite	Q4QQW1.
Proteomic databases
PRIDE	Q4QQW1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000015169; ENSRNOP00000015169; ENSRNOG00000011373.
GeneID	306014.
KEGG	rno:306014.
UCSC	RGD:1306561. rat.
Organism-specific databases
CTD	80346.
RGD	1306561. Reep4.
Phylogenomic databases
eggNOG	COG5052.
GeneTree	ENSGT00550000074535.
HOGENOM	HOG000007472.
HOVERGEN	HBG056861.
InParanoid	Q4QQW1.
OMA	YLEDQVP.
OrthoDB	EOG4HQDK4.
Gene expression databases
Genevestigator	Q4QQW1.
GermOnline	ENSRNOG00000011373. Rattus norvegicus.
Family and domain databases
InterPro	IPR004345. TB2_DP1_HVA22. [Graphical view]
PANTHER	PTHR12300. PTHR12300. 1 hit.
Pfam	PF03134. TB2_DP1_HVA22. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	655414.

Entry information

Entry name

REEP4_RAT

Accession

Primary (citable) accession number: Q4QQW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	July 19, 2005
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program