Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q4QQW1

- REEP4_RAT

UniProt

Q4QQW1 - REEP4_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Receptor expression-enhancing protein 4

Gene

Reep4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity).By similarity

GO - Molecular functioni

  1. microtubule binding Source: UniProtKB

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
  2. mitotic nuclear envelope reassembly Source: UniProtKB
  3. nuclear envelope organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor expression-enhancing protein 4
Gene namesi
Name:Reep4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 15

Organism-specific databases

RGDi1306561. Reep4.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257Receptor expression-enhancing protein 4PRO_0000101833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei152 – 1521PhosphoserineBy similarity
Modified residuei194 – 1941PhosphoserineBy similarity
Modified residuei196 – 1961PhosphothreonineBy similarity
Modified residuei202 – 2021PhosphoserineBy similarity
Modified residuei250 – 2501PhosphothreonineBy similarity
Modified residuei253 – 2531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ4QQW1.

PTM databases

PhosphoSiteiQ4QQW1.

Expressioni

Gene expression databases

GenevestigatoriQ4QQW1.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015169.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the DP1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5052.
GeneTreeiENSGT00550000074535.
HOGENOMiHOG000007472.
HOVERGENiHBG056861.
InParanoidiQ4QQW1.
KOiK17338.
OMAiTYQDPLY.
OrthoDBiEOG71RXJX.
PhylomeDBiQ4QQW1.
TreeFamiTF314177.

Family and domain databases

InterProiIPR004345. TB2_DP1_HVA22.
[Graphical view]
PANTHERiPTHR12300. PTHR12300. 1 hit.
PfamiPF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQW1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSWMICRLV VLIFGMLYPA YASYKAVKSK NIREYVRWMM YWIVFAIFMA
60 70 80 90 100
AETFTDIFIS WFPFYYEIKM AFVLWLLSPY TKGASLLYRK FVHPSLSRHE
110 120 130 140 150
KEIDACIVQA KERSYETMLS FGKRSLNMAA SAAVQAATKS QGALAGRLRS
160 170 180 190 200
FSMQDLRSIP DTSAPTYQDP LYLEDQAPRR RPPIGYRPGG LQDSDTEDEC
210 220 230 240 250
WSDNEIAPQP PVRPREKPLS RSQSLRVVKR KPLVREGTSR SLKVRTRKKT

IPSDLDS
Length:257
Mass (Da):29,660
Last modified:July 19, 2005 - v1
Checksum:i4F7A370129800F13
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097957 mRNA. Translation: AAH97957.1.
RefSeqiNP_001020450.1. NM_001025279.1.
UniGeneiRn.6988.

Genome annotation databases

EnsembliENSRNOT00000015169; ENSRNOP00000015169; ENSRNOG00000011373.
GeneIDi306014.
KEGGirno:306014.
UCSCiRGD:1306561. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC097957 mRNA. Translation: AAH97957.1 .
RefSeqi NP_001020450.1. NM_001025279.1.
UniGenei Rn.6988.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015169.

PTM databases

PhosphoSitei Q4QQW1.

Proteomic databases

PRIDEi Q4QQW1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000015169 ; ENSRNOP00000015169 ; ENSRNOG00000011373 .
GeneIDi 306014.
KEGGi rno:306014.
UCSCi RGD:1306561. rat.

Organism-specific databases

CTDi 80346.
RGDi 1306561. Reep4.

Phylogenomic databases

eggNOGi COG5052.
GeneTreei ENSGT00550000074535.
HOGENOMi HOG000007472.
HOVERGENi HBG056861.
InParanoidi Q4QQW1.
KOi K17338.
OMAi TYQDPLY.
OrthoDBi EOG71RXJX.
PhylomeDBi Q4QQW1.
TreeFami TF314177.

Miscellaneous databases

NextBioi 655414.
PROi Q4QQW1.

Gene expression databases

Genevestigatori Q4QQW1.

Family and domain databases

InterProi IPR004345. TB2_DP1_HVA22.
[Graphical view ]
PANTHERi PTHR12300. PTHR12300. 1 hit.
Pfami PF03134. TB2_DP1_HVA22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS."
    Moser K., White F.M.
    J. Proteome Res. 5:98-104(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiREEP4_RAT
AccessioniPrimary (citable) accession number: Q4QQW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3