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Protein

Docking protein 1

Gene

Dok1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 1
Alternative name(s):
Downstream of tyrosine kinase 1
Gene namesi
Name:Dok1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1309499. Dok1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Docking protein 1PRO_0000356279Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei48 – 481PhosphoserineBy similarity
Modified residuei269 – 2691PhosphoserineBy similarity
Modified residuei290 – 2901PhosphoserineBy similarity
Modified residuei295 – 2951PhosphotyrosineBy similarity
Modified residuei336 – 3361PhosphotyrosineBy similarity
Modified residuei340 – 3401PhosphotyrosineBy similarity
Modified residuei361 – 3611Phosphotyrosine; by INSRBy similarity
Modified residuei376 – 3761PhosphotyrosineBy similarity
Modified residuei397 – 3971Phosphotyrosine; by INSRBy similarity
Modified residuei408 – 4081PhosphotyrosineBy similarity
Modified residuei415 – 4151PhosphoserineBy similarity
Modified residuei448 – 4481PhosphotyrosineBy similarity

Post-translational modificationi

Constitutively tyrosine-phosphorylated (By similarity). Phosphorylated by TEC. Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway (By similarity). Phosphorylated on tyrosine residues by SRMS (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ4QQV2.
PRIDEiQ4QQV2.

PTM databases

iPTMnetiQ4QQV2.
PhosphoSiteiQ4QQV2.

Expressioni

Gene expression databases

GenevisibleiQ4QQV2. RN.

Interactioni

Subunit structurei

Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3 (By similarity). Interacts with SRMS (via the SH2 and SH3 domains) (By similarity).By similarity

Protein-protein interaction databases

BioGridi260183. 4 interactions.
IntActiQ4QQV2. 3 interactions.
MINTiMINT-2517100.
STRINGi10116.ENSRNOP00000010020.

Structurei

3D structure databases

ProteinModelPortaliQ4QQV2.
SMRiQ4QQV2. Positions 152-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 119117PHAdd
BLAST
Domaini151 – 259109IRS-type PTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 31738Pro-richAdd
BLAST
Compositional biasi359 – 43072Pro-richAdd
BLAST

Domaini

The PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type A subfamily.Curated
Contains 1 IRS-type PTB domain.PROSITE-ProRule annotation
Contains 1 PH domain.Curated

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000112245.
HOVERGENiHBG018962.
InParanoidiQ4QQV2.
KOiK14752.
OMAiWPYTLLR.
OrthoDBiEOG77WWC5.
PhylomeDBiQ4QQV2.
TreeFamiTF324994.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGALMEGPL FLQSQRFGTK RWKKTWAVLY PASPHGVARL EFFDHKGSSS
60 70 80 90 100
GGGRGGSRRL DCKMIRLAEC VSVVPVTVES PPEPGASAFR LDTAQRSHLL
110 120 130 140 150
AADAASSTAW VQILCRTAFP KGGWALAQTE NPPKFSALEM LENSLYSPTW
160 170 180 190 200
EGSQFWVTSQ KTEASERCGL QGSYVLRVEA EKLTLLTLGA QSQILEPLLF
210 220 230 240 250
WPYTLLRRYG RDKVMFSFEA GRRCPSGPGT FTFQTAQGND IFQAVEAAIQ
260 270 280 290 300
QQKAQGKVGQ GQDITRTDSH DGETEGKMAP TPVPQEPLGS PPALYAEPLD
310 320 330 340 350
SLRIPPGPSQ DSLYSDPLGS TPAGAGEGVQ RKKPLYWDLY GHVQQQLLKT
360 370 380 390 400
KLIDSKEDPI YDEPEGLAPA PLRGLYDLPQ EPKDAWWCQA RLKEEGYELP
410 420 430 440 450
YNPATDDYAV PPPRSSKPTP APKPQGLILP ESGTTAGSGS KGSDTALYSQ
460 470 480
VQKSGTPGRW DCGLSRVGND RVGVKSEGST
Length:480
Mass (Da):52,170
Last modified:July 19, 2005 - v1
Checksum:iB276AC33DDA9F194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097972 mRNA. Translation: AAH97972.1.
RefSeqiNP_001020587.1. NM_001025416.1.
UniGeneiRn.117974.

Genome annotation databases

EnsembliENSRNOT00000010020; ENSRNOP00000010020; ENSRNOG00000007412.
GeneIDi312477.
KEGGirno:312477.
UCSCiRGD:1309499. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097972 mRNA. Translation: AAH97972.1.
RefSeqiNP_001020587.1. NM_001025416.1.
UniGeneiRn.117974.

3D structure databases

ProteinModelPortaliQ4QQV2.
SMRiQ4QQV2. Positions 152-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi260183. 4 interactions.
IntActiQ4QQV2. 3 interactions.
MINTiMINT-2517100.
STRINGi10116.ENSRNOP00000010020.

PTM databases

iPTMnetiQ4QQV2.
PhosphoSiteiQ4QQV2.

Proteomic databases

PaxDbiQ4QQV2.
PRIDEiQ4QQV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010020; ENSRNOP00000010020; ENSRNOG00000007412.
GeneIDi312477.
KEGGirno:312477.
UCSCiRGD:1309499. rat.

Organism-specific databases

CTDi1796.
RGDi1309499. Dok1.

Phylogenomic databases

eggNOGiKOG4047. Eukaryota.
ENOG410XS2S. LUCA.
GeneTreeiENSGT00730000110348.
HOGENOMiHOG000112245.
HOVERGENiHBG018962.
InParanoidiQ4QQV2.
KOiK14752.
OMAiWPYTLLR.
OrthoDBiEOG77WWC5.
PhylomeDBiQ4QQV2.
TreeFamiTF324994.

Enzyme and pathway databases

ReactomeiR-RNO-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.

Miscellaneous databases

PROiQ4QQV2.

Gene expression databases

GenevisibleiQ4QQV2. RN.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiDOK1_RAT
AccessioniPrimary (citable) accession number: Q4QQV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 19, 2005
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.