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Protein

Tax1-binding protein 3

Gene

Tax1bp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-RNO-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 3
Gene namesi
Name:Tax1bp3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1308924 Tax1bp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002339452 – 98Tax1-binding protein 3Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4QQV1
PRIDEiQ4QQV1

Expressioni

Tissue specificityi

Detected in kidney distal convoluted tubules (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000019357
GenevisibleiQ4QQV1 RN

Interactioni

Subunit structurei

Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding (By similarity). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1 (By similarity). Interacts with ADGRB2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053298

Structurei

3D structure databases

ProteinModelPortaliQ4QQV1
SMRiQ4QQV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 87PDZSequence analysisAdd BLAST76

Phylogenomic databases

eggNOGiKOG3553 Eukaryota
ENOG4111IK0 LUCA
GeneTreeiENSGT00390000002877
HOGENOMiHOG000015753
HOVERGENiHBG052814
InParanoidiQ4QQV1
OMAiHKETEIN
OrthoDBiEOG091G0UZR

Family and domain databases

InterProiView protein in InterPro
IPR036034 PDZ_sf
IPR017268 Tax1-binding_p3
PANTHERiPTHR23136 PTHR23136, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QQV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK
60 70 80 90
TDKVNGWDMT MVTHDQARKR LTKRSEEVVR LLVTRQSLQK AVQQSMLS
Length:98
Mass (Da):11,050
Last modified:July 19, 2005 - v1
Checksum:iC58A4ECC5F0E1EC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097976 mRNA Translation: AAH97976.1
RefSeqiNP_001020590.1, NM_001025419.1
UniGeneiRn.34842

Genome annotation databases

EnsembliENSRNOT00000056460; ENSRNOP00000053298; ENSRNOG00000019357
GeneIDi360564
KEGGirno:360564

Similar proteinsi

Entry informationi

Entry nameiTX1B3_RAT
AccessioniPrimary (citable) accession number: Q4QQV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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