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Protein

Tax1-binding protein 3

Gene

Tax1bp3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-RNO-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Names & Taxonomyi

Protein namesi
Recommended name:
Tax1-binding protein 3
Gene namesi
Name:Tax1bp3Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1308924. Tax1bp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 9897Tax1-binding protein 3PRO_0000233945Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4QQV1.
PRIDEiQ4QQV1.

Expressioni

Tissue specificityi

Detected in kidney distal convoluted tubules (at protein level).1 Publication

Gene expression databases

GenevisibleiQ4QQV1. RN.

Interactioni

Subunit structurei

Interacts (via its PDZ domain) with GLS2. Interacts (via its PDZ domain) with RTKN (via the C-terminal region); this interaction facilitates Rho-mediated activation of the FOS serum response element (SRE). Interacts (via PDZ domain) with ARHGEF16. Interacts (via PDZ domain) with KCNJ4 (via C-terminus). Competes with LIN7A for KCNJ4 binding (By similarity). Interacts (via its PDZ domain) with CTNNB1; this interaction inhibits the transcriptional activity of CTNNB1 (By similarity). Interacts with ADGRB2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053298.

Structurei

3D structure databases

ProteinModelPortaliQ4QQV1.
SMRiQ4QQV1. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 8776PDZSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PDZ (DHR) domain.Sequence analysis

Phylogenomic databases

eggNOGiKOG3553. Eukaryota.
ENOG4111IK0. LUCA.
GeneTreeiENSGT00390000002877.
HOGENOMiHOG000015753.
HOVERGENiHBG052814.
InParanoidiQ4QQV1.
OMAiDPTQNPF.
OrthoDBiEOG7S4X7S.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017268. Tax1-binding_p3.
[Graphical view]
PANTHERiPTHR23136. PTHR23136. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QQV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK
60 70 80 90
TDKVNGWDMT MVTHDQARKR LTKRSEEVVR LLVTRQSLQK AVQQSMLS
Length:98
Mass (Da):11,050
Last modified:July 19, 2005 - v1
Checksum:iC58A4ECC5F0E1EC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097976 mRNA. Translation: AAH97976.1.
RefSeqiNP_001020590.1. NM_001025419.1.
UniGeneiRn.34842.

Genome annotation databases

EnsembliENSRNOT00000056460; ENSRNOP00000053298; ENSRNOG00000019357.
GeneIDi360564.
KEGGirno:360564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097976 mRNA. Translation: AAH97976.1.
RefSeqiNP_001020590.1. NM_001025419.1.
UniGeneiRn.34842.

3D structure databases

ProteinModelPortaliQ4QQV1.
SMRiQ4QQV1. Positions 1-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053298.

Proteomic databases

PaxDbiQ4QQV1.
PRIDEiQ4QQV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000056460; ENSRNOP00000053298; ENSRNOG00000019357.
GeneIDi360564.
KEGGirno:360564.

Organism-specific databases

CTDi30851.
RGDi1308924. Tax1bp3.

Phylogenomic databases

eggNOGiKOG3553. Eukaryota.
ENOG4111IK0. LUCA.
GeneTreeiENSGT00390000002877.
HOGENOMiHOG000015753.
HOVERGENiHBG052814.
InParanoidiQ4QQV1.
OMAiDPTQNPF.
OrthoDBiEOG7S4X7S.

Enzyme and pathway databases

ReactomeiR-RNO-5666185. RHO GTPases Activate Rhotekin and Rhophilins.

Miscellaneous databases

PROiQ4QQV1.

Gene expression databases

GenevisibleiQ4QQV1. RN.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR017268. Tax1-binding_p3.
[Graphical view]
PANTHERiPTHR23136. PTHR23136. 1 hit.
SUPFAMiSSF50156. SSF50156. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiTX1B3_RAT
AccessioniPrimary (citable) accession number: Q4QQV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 19, 2005
Last modified: June 8, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.