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Protein

Growth hormone-regulated TBC protein 1

Gene

Grtp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-regulated TBC protein 1
Gene namesi
Name:Grtp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1309210. Grtp1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002887101 – 289Growth hormone-regulated TBC protein 1Add BLAST289

Proteomic databases

PaxDbiQ4QQU7.
PRIDEiQ4QQU7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000061995.
GenevisibleiQ4QQU7. RN.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ4QQU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 211Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST171

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00860000133698.
HOGENOMiHOG000045576.
HOVERGENiHBG107100.
InParanoidiQ4QQU7.
KOiK19953.

Family and domain databases

InterProiView protein in InterPro
IPR000195. Rab-GTPase-TBC_dom.
IPR035969. Rab-GTPase_TBC_sf.
PfamiView protein in Pfam
PF00566. RabGAP-TBC. 1 hit.
SMARTiView protein in SMART
SM00164. TBC. 1 hit.
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiView protein in PROSITE
PS50086. TBC_RABGAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4QQU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAERAQAA RARVPRIDPY GFERPEDFDY AAYEEFFSTY LVILTKRAIK
60 70 80 90 100
WSKLLKGSGG VRKSVTDLNR TFPDNVMFRK TADPCLQKTL YNVLLAYGLH
110 120 130 140 150
NQDVGYCQGM NFIAGYLILI TKNEEESFWL LDALVGRILP DYYSPAMLGL
160 170 180 190 200
KTDQEVLAEL VRMKLPAVAA LMDGHGVLWT LLVSRWFICL FVDILPVETV
210 220 230 240 250
LRIWDCLFNE GSKIIFRVAL TLIKQHQEFI LEASSVPDIC DKFKQITKGD
260 270 280
FVTECHTFMQ KIFSEPGSLS MATITRLRES CRAALQAQS
Length:289
Mass (Da):32,929
Last modified:July 19, 2005 - v1
Checksum:i443EEF24301CB523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097985 mRNA. Translation: AAH97985.1.
RefSeqiNP_001026983.1. NM_001031813.2.
UniGeneiRn.19589.

Genome annotation databases

EnsembliENSRNOT00000073240; ENSRNOP00000065337; ENSRNOG00000061995.
GeneIDi361180.
KEGGirno:361180.
UCSCiRGD:1309210. rat.

Similar proteinsi

Entry informationi

Entry nameiGRTP1_RAT
AccessioniPrimary (citable) accession number: Q4QQU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome