Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Growth hormone-regulated TBC protein 1

Gene

Grtp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-regulated TBC protein 1
Gene namesi
Name:Grtp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi1309210. Grtp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Growth hormone-regulated TBC protein 1PRO_0000288710Add
BLAST

Proteomic databases

PaxDbiQ4QQU7.
PRIDEiQ4QQU7.

Expressioni

Gene expression databases

GenevisibleiQ4QQU7. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054552.

Structurei

3D structure databases

ProteinModelPortaliQ4QQU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 211171Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000045576.
HOVERGENiHBG107100.
InParanoidiQ4QQU7.
KOiK19953.
OrthoDBiEOG76DTS1.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPAERAQAA RARVPRIDPY GFERPEDFDY AAYEEFFSTY LVILTKRAIK
60 70 80 90 100
WSKLLKGSGG VRKSVTDLNR TFPDNVMFRK TADPCLQKTL YNVLLAYGLH
110 120 130 140 150
NQDVGYCQGM NFIAGYLILI TKNEEESFWL LDALVGRILP DYYSPAMLGL
160 170 180 190 200
KTDQEVLAEL VRMKLPAVAA LMDGHGVLWT LLVSRWFICL FVDILPVETV
210 220 230 240 250
LRIWDCLFNE GSKIIFRVAL TLIKQHQEFI LEASSVPDIC DKFKQITKGD
260 270 280
FVTECHTFMQ KIFSEPGSLS MATITRLRES CRAALQAQS
Length:289
Mass (Da):32,929
Last modified:July 19, 2005 - v1
Checksum:i443EEF24301CB523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097985 mRNA. Translation: AAH97985.1.
RefSeqiNP_001026983.1. NM_001031813.2.
UniGeneiRn.19589.

Genome annotation databases

EnsembliENSRNOT00000073240; ENSRNOP00000065337; ENSRNOG00000061995.
GeneIDi361180.
KEGGirno:361180.
UCSCiRGD:1309210. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC097985 mRNA. Translation: AAH97985.1.
RefSeqiNP_001026983.1. NM_001031813.2.
UniGeneiRn.19589.

3D structure databases

ProteinModelPortaliQ4QQU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054552.

Proteomic databases

PaxDbiQ4QQU7.
PRIDEiQ4QQU7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000073240; ENSRNOP00000065337; ENSRNOG00000061995.
GeneIDi361180.
KEGGirno:361180.
UCSCiRGD:1309210. rat.

Organism-specific databases

CTDi79774.
RGDi1309210. Grtp1.

Phylogenomic databases

eggNOGiENOG410IEA9. Eukaryota.
ENOG410XPXD. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000045576.
HOVERGENiHBG107100.
InParanoidiQ4QQU7.
KOiK19953.
OrthoDBiEOG76DTS1.

Miscellaneous databases

PROiQ4QQU7.

Gene expression databases

GenevisibleiQ4QQU7. RN.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiGRTP1_RAT
AccessioniPrimary (citable) accession number: Q4QQU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 19, 2005
Last modified: June 8, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.