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Protein

Ribosome biogenesis protein BRX1 homolog

Gene

Brix1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required for biogenesis of the 60S ribosomal subunit.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BRX1 homolog
Alternative name(s):
Brix domain-containing protein 2
Gene namesi
Name:Brix1
Synonyms:Brix, Bxdc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1308508. Brix1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Ribosome biogenesis protein BRX1 homologPRO_0000269726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751N6-acetyllysineBy similarity
Cross-linki321 – 321Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ4QQT6.
PRIDEiQ4QQT6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024285.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini59 – 248190BrixPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BRX1 family.Curated
Contains 1 Brix domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2971. Eukaryota.
COG5154. LUCA.
HOGENOMiHOG000212937.
HOVERGENiHBG039185.
InParanoidiQ4QQT6.
KOiK14820.
PhylomeDBiQ4QQT6.

Family and domain databases

InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
IPR026532. BRX1.
[Graphical view]
PANTHERiPTHR13634. PTHR13634. 1 hit.
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATKRKRRG DLEVQAKKPK KNRKDAGQPA KQADVAKEAE EEKDRIPGPV
60 70 80 90 100
CKGKWKNKER ILIFSSRGIN FRTRHLMQDL RMLMPHSKAD TKMDRKDKLF
110 120 130 140 150
VINEVCEMKN CNKCIYFEAK KKQDLYMWLS NSPHGPSAKF LVQNIHTLAE
160 170 180 190 200
LKMTGNCLKG SRPLLSFDPA FDDLPHYALL KEFLIQIFST PRYHPKSQPF
210 220 230 240 250
VDHVFTFTIL DNRIWFRNFQ IIEEDAALVE IGPRFVLNLI KIFQGSFGGP
260 270 280 290 300
TLYENPHYQS PNMHRRVVRS ITAAKYREKQ QVKDVQKSRK KEPKTILPHD
310 320 330 340 350
PTADVFVTPA EEKPIEVQWV KPEPKVDLKA RKRRIYKRHR KLQQKMSRGG

AK
Length:352
Mass (Da):41,115
Last modified:July 19, 2005 - v1
Checksum:iF5942D395FC7CCA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098005 mRNA. Translation: AAH98005.1.
RefSeqiNP_001025086.1. NM_001029915.1.
UniGeneiRn.17880.

Genome annotation databases

GeneIDi294799.
KEGGirno:294799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098005 mRNA. Translation: AAH98005.1.
RefSeqiNP_001025086.1. NM_001029915.1.
UniGeneiRn.17880.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024285.

Proteomic databases

PaxDbiQ4QQT6.
PRIDEiQ4QQT6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi294799.
KEGGirno:294799.

Organism-specific databases

CTDi55299.
RGDi1308508. Brix1.

Phylogenomic databases

eggNOGiKOG2971. Eukaryota.
COG5154. LUCA.
HOGENOMiHOG000212937.
HOVERGENiHBG039185.
InParanoidiQ4QQT6.
KOiK14820.
PhylomeDBiQ4QQT6.

Miscellaneous databases

NextBioi638598.
PROiQ4QQT6.

Family and domain databases

InterProiIPR004154. Anticodon-bd.
IPR007109. Brix.
IPR026532. BRX1.
[Graphical view]
PANTHERiPTHR13634. PTHR13634. 1 hit.
PfamiPF04427. Brix. 1 hit.
[Graphical view]
SMARTiSM00879. Brix. 1 hit.
[Graphical view]
SUPFAMiSSF52954. SSF52954. 1 hit.
PROSITEiPS50833. BRIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiBRX1_RAT
AccessioniPrimary (citable) accession number: Q4QQT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.