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Q4QQT5

- IDHG2_RAT

UniProt

Q4QQT5 - IDHG2_RAT

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Protein

Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei133 – 1331SubstrateBy similarity
Binding sitei164 – 1641SubstrateBy similarity
Sitei171 – 1711Critical for catalysisBy similarity
Sitei218 – 2181Critical for catalysisBy similarity
Metal bindingi251 – 2511Magnesium or manganeseBy similarity
Binding sitei251 – 2511SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 8129NADSequence AnalysisAdd
BLAST
Nucleotide bindingi306 – 3138ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
  4. NAD binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial (EC:1.1.1.41)
Alternative name(s):
Isocitric dehydrogenase subunit gamma 2
NAD(+)-specific ICDH subunit gamma 2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi1642415. LOC100125384.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
BLAST
Chaini26 – 395370Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrialPRO_0000401934Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ4QQT5. baseline.
GenevestigatoriQ4QQT5.

Interactioni

Subunit structurei

Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ4QQT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00590000083091.
HOVERGENiHBG052080.
InParanoidiQ4QQT5.
KOiK00030.
OMAiHRNIANP.
OrthoDBiEOG75B85R.
PhylomeDBiQ4QQT5.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QQT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAAGSCSVR TILQPALLLG HSREVVCELV TSFRNFCSKY SVPPSPKYGG
60 70 80 90 100
KHTVTMIPGD GIGPELMVHV KRIFRSNCVP VEFEEVWATS TSSEEEINNA
110 120 130 140 150
LMAIRRNRIT LKGNIATNHH LPAKYKSHNT KFRTALDLYA SVVHFKTFPG
160 170 180 190 200
VETRHKDIDI LVVRENTEGE YTNLEHESVR GVVESLKIVT KTKSVRIADY
210 220 230 240 250
AFRLAQKMGR KKVTVVHKAN IMKLGDGLFL QCCKDVAAHY PQITLESMII
260 270 280 290 300
DNTAMQLVSK PQQFDVMLMP NLYGNIINSV CTGLVGGSGI VPGANYGDSY
310 320 330 340 350
AIFETGSKEI GQDLAHRNIA NPVAMLLTSC IMLDYLDLQL YAAHIRSAVM
360 370 380 390
ASLQNKSICT PDIGGQGTTA GVVEYILDHM KDQNSGCQPR FFLST
Length:395
Mass (Da):43,568
Last modified:July 19, 2005 - v1
Checksum:iC9CCD35DC729465B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM07215.1.
BC098006 mRNA. Translation: AAH98006.1.
RefSeqiNP_001096833.1. NM_001103363.1.
XP_008757687.1. XM_008759465.1.
UniGeneiRn.215024.

Genome annotation databases

EnsembliENSRNOT00000074027; ENSRNOP00000066907; ENSRNOG00000045720.
GeneIDi100125384.
103690168.
KEGGirno:100125384.
rno:100909825.
UCSCiRGD:1642415. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473979 Genomic DNA. Translation: EDM07215.1 .
BC098006 mRNA. Translation: AAH98006.1 .
RefSeqi NP_001096833.1. NM_001103363.1.
XP_008757687.1. XM_008759465.1.
UniGenei Rn.215024.

3D structure databases

ProteinModelPortali Q4QQT5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000074027 ; ENSRNOP00000066907 ; ENSRNOG00000045720 .
GeneIDi 100125384.
103690168.
KEGGi rno:100125384.
rno:100909825.
UCSCi RGD:1642415. rat.

Organism-specific databases

RGDi 1642415. LOC100125384.

Phylogenomic databases

GeneTreei ENSGT00590000083091.
HOVERGENi HBG052080.
InParanoidi Q4QQT5.
KOi K00030.
OMAi HRNIANP.
OrthoDBi EOG75B85R.
PhylomeDBi Q4QQT5.

Miscellaneous databases

NextBioi 744472.

Gene expression databases

ExpressionAtlasi Q4QQT5. baseline.
Genevestigatori Q4QQT5.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiIDHG2_RAT
AccessioniPrimary (citable) accession number: Q4QQT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: July 19, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3