Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q4QQT5

- IDHG2_RAT

UniProt

Q4QQT5 - IDHG2_RAT

Protein

Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial

Gene
N/A
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (19 Jul 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei133 – 1331SubstrateBy similarity
    Binding sitei164 – 1641SubstrateBy similarity
    Sitei171 – 1711Critical for catalysisBy similarity
    Sitei218 – 2181Critical for catalysisBy similarity
    Metal bindingi251 – 2511Magnesium or manganeseBy similarity
    Binding sitei251 – 2511SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi53 – 8129NADSequence AnalysisAdd
    BLAST
    Nucleotide bindingi306 – 3138ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    3. magnesium ion binding Source: InterPro
    4. NAD binding Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, NAD, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial (EC:1.1.1.41)
    Alternative name(s):
    Isocitric dehydrogenase subunit gamma 2
    NAD(+)-specific ICDH subunit gamma 2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi1642415. LOC100125384.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
    BLAST
    Chaini26 – 395370Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrialPRO_0000401934Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ4QQT5.

    Interactioni

    Subunit structurei

    Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ4QQT5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    GeneTreeiENSGT00590000083091.
    HOVERGENiHBG052080.
    KOiK00030.
    OMAiHRNIANP.
    OrthoDBiEOG75B85R.
    PhylomeDBiQ4QQT5.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q4QQT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLAAGSCSVR TILQPALLLG HSREVVCELV TSFRNFCSKY SVPPSPKYGG    50
    KHTVTMIPGD GIGPELMVHV KRIFRSNCVP VEFEEVWATS TSSEEEINNA 100
    LMAIRRNRIT LKGNIATNHH LPAKYKSHNT KFRTALDLYA SVVHFKTFPG 150
    VETRHKDIDI LVVRENTEGE YTNLEHESVR GVVESLKIVT KTKSVRIADY 200
    AFRLAQKMGR KKVTVVHKAN IMKLGDGLFL QCCKDVAAHY PQITLESMII 250
    DNTAMQLVSK PQQFDVMLMP NLYGNIINSV CTGLVGGSGI VPGANYGDSY 300
    AIFETGSKEI GQDLAHRNIA NPVAMLLTSC IMLDYLDLQL YAAHIRSAVM 350
    ASLQNKSICT PDIGGQGTTA GVVEYILDHM KDQNSGCQPR FFLST 395
    Length:395
    Mass (Da):43,568
    Last modified:July 19, 2005 - v1
    Checksum:iC9CCD35DC729465B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473979 Genomic DNA. Translation: EDM07215.1.
    BC098006 mRNA. Translation: AAH98006.1.
    RefSeqiNP_001096833.1. NM_001103363.1.
    XP_003748914.1. XM_003748866.2.
    UniGeneiRn.215024.

    Genome annotation databases

    EnsembliENSRNOT00000074027; ENSRNOP00000066907; ENSRNOG00000045720.
    GeneIDi100125384.
    100909825.
    KEGGirno:100125384.
    rno:100909825.
    UCSCiRGD:1642415. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH473979 Genomic DNA. Translation: EDM07215.1 .
    BC098006 mRNA. Translation: AAH98006.1 .
    RefSeqi NP_001096833.1. NM_001103363.1.
    XP_003748914.1. XM_003748866.2.
    UniGenei Rn.215024.

    3D structure databases

    ProteinModelPortali Q4QQT5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074027 ; ENSRNOP00000066907 ; ENSRNOG00000045720 .
    GeneIDi 100125384.
    100909825.
    KEGGi rno:100125384.
    rno:100909825.
    UCSCi RGD:1642415. rat.

    Organism-specific databases

    RGDi 1642415. LOC100125384.

    Phylogenomic databases

    GeneTreei ENSGT00590000083091.
    HOVERGENi HBG052080.
    KOi K00030.
    OMAi HRNIANP.
    OrthoDBi EOG75B85R.
    PhylomeDBi Q4QQT5.

    Miscellaneous databases

    NextBioi 744472.

    Gene expression databases

    Genevestigatori Q4QQT5.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004434. Isocitrate_DH_NAD.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown Norway.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiIDHG2_RAT
    AccessioniPrimary (citable) accession number: Q4QQT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: July 19, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3