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Protein

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Gene

Ppp2r1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-RNO-163685. Integration of energy metabolism.
R-RNO-163767. PP2A-mediated dephosphorylation of key metabolic factors.
R-RNO-180024. DARPP-32 events.
R-RNO-195253. Degradation of beta-catenin by the destruction complex.
R-RNO-196299. Beta-catenin phosphorylation cascade.
R-RNO-198753. ERK/MAPK targets.
R-RNO-202670. ERKs are inactivated.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-389513. CTLA4 inhibitory signaling.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-5673000. RAF activation.
R-RNO-5675221. Negative regulation of MAPK pathway.
R-RNO-6804757. Regulation of TP53 Degradation.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-RNO-68877. Mitotic Prometaphase.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69273. Cyclin A/B1 associated events during G2/M transition.
R-RNO-70171. Glycolysis.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Alternative name(s):
PP2A subunit A isoform PR65-beta
PP2A subunit A isoform R1-beta
Gene namesi
Name:Ppp2r1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1304764. Ppp2r1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714062 – 601Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4QQT4.
PRIDEiQ4QQT4.

PTM databases

iPTMnetiQ4QQT4.
PhosphoSitePlusiQ4QQT4.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010922.
GenevisibleiQ4QQT4. RN.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 (By similarity). Interacts with SGO1 (By similarity). Interacts with RAF1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ4QQT4. 1 interactor.
STRINGi10116.ENSRNOP00000059428.

Structurei

3D structure databases

ProteinModelPortaliQ4QQT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 58HEAT 1Add BLAST39
Repeati59 – 96HEAT 2Add BLAST38
Repeati97 – 135HEAT 3Add BLAST39
Repeati136 – 173HEAT 4Add BLAST38
Repeati174 – 212HEAT 5Add BLAST39
Repeati213 – 251HEAT 6Add BLAST39
Repeati252 – 290HEAT 7Add BLAST39
Repeati291 – 333HEAT 8Add BLAST43
Repeati334 – 372HEAT 9Add BLAST39
Repeati373 – 411HEAT 10Add BLAST39
Repeati412 – 450HEAT 11Add BLAST39
Repeati451 – 489HEAT 12Add BLAST39
Repeati490 – 528HEAT 13Add BLAST39
Repeati529 – 567HEAT 14Add BLAST39
Repeati568 – 601HEAT 15Add BLAST34

Domaini

Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.

Sequence similaritiesi

Contains 15 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0211. Eukaryota.
ENOG410XQVI. LUCA.
GeneTreeiENSGT00730000110944.
HOGENOMiHOG000078539.
HOVERGENiHBG000011.
InParanoidiQ4QQT4.
KOiK03456.
OMAiCGREITT.
OrthoDBiEOG091G045V.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR031090. PP2A_A_meta.
[Graphical view]
PANTHERiPTHR10648:SF9. PTHR10648:SF9. 1 hit.
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QQT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAAGPGTV PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI
60 70 80 90 100
ALALGVERTR TELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC
110 120 130 140 150
LLPPLESLAT VEETVVRDKA VESLRQISQE HTPVALEAHF VPLVKRLASG
160 170 180 190 200
DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ HFRSLCSDDT PMVRRAAASK
210 220 230 240 250
LGEFAKVLEL DSVKTEIVPL FTNLASDEQD SVRLLAVEAC VSIAQLLSQD
260 270 280 290 300
DLEALVMPTL RQAAEDKSWR VRYMVADKFS ELQKAVGPKI ALSDLIPAFQ
310 320 330 340 350
SLLRDCEAEV RAAAAHKVRE LCENLPTEGR ETVIMNQILP YIKELVSDTN
360 370 380 390 400
QHVKSALASV IMGLSTVLGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL
410 420 430 440 450
DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF
460 470 480 490 500
FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV
510 520 530 540 550
MANDPNYLHR MTTLFCINAL SEACGKEITT KQMLPIVLKM AGDQVANVRF
560 570 580 590 600
NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL

A
Length:601
Mass (Da):66,006
Last modified:July 19, 2005 - v1
Checksum:iDA2A0BA19FC5A46D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098007 mRNA. Translation: AAH98007.1.
RefSeqiNP_001020589.1. NM_001025418.1.
UniGeneiRn.163017.

Genome annotation databases

EnsembliENSRNOT00000064290; ENSRNOP00000059428; ENSRNOG00000010922.
GeneIDi315648.
KEGGirno:315648.
UCSCiRGD:1304764. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098007 mRNA. Translation: AAH98007.1.
RefSeqiNP_001020589.1. NM_001025418.1.
UniGeneiRn.163017.

3D structure databases

ProteinModelPortaliQ4QQT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ4QQT4. 1 interactor.
STRINGi10116.ENSRNOP00000059428.

PTM databases

iPTMnetiQ4QQT4.
PhosphoSitePlusiQ4QQT4.

Proteomic databases

PaxDbiQ4QQT4.
PRIDEiQ4QQT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000064290; ENSRNOP00000059428; ENSRNOG00000010922.
GeneIDi315648.
KEGGirno:315648.
UCSCiRGD:1304764. rat.

Organism-specific databases

CTDi5519.
RGDi1304764. Ppp2r1b.

Phylogenomic databases

eggNOGiKOG0211. Eukaryota.
ENOG410XQVI. LUCA.
GeneTreeiENSGT00730000110944.
HOGENOMiHOG000078539.
HOVERGENiHBG000011.
InParanoidiQ4QQT4.
KOiK03456.
OMAiCGREITT.
OrthoDBiEOG091G045V.

Enzyme and pathway databases

ReactomeiR-RNO-113501. Inhibition of replication initiation of damaged DNA by RB1/E2F1.
R-RNO-163685. Integration of energy metabolism.
R-RNO-163767. PP2A-mediated dephosphorylation of key metabolic factors.
R-RNO-180024. DARPP-32 events.
R-RNO-195253. Degradation of beta-catenin by the destruction complex.
R-RNO-196299. Beta-catenin phosphorylation cascade.
R-RNO-198753. ERK/MAPK targets.
R-RNO-202670. ERKs are inactivated.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2500257. Resolution of Sister Chromatid Cohesion.
R-RNO-389513. CTLA4 inhibitory signaling.
R-RNO-5663220. RHO GTPases Activate Formins.
R-RNO-5673000. RAF activation.
R-RNO-5675221. Negative regulation of MAPK pathway.
R-RNO-6804757. Regulation of TP53 Degradation.
R-RNO-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-RNO-68877. Mitotic Prometaphase.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69273. Cyclin A/B1 associated events during G2/M transition.
R-RNO-70171. Glycolysis.

Miscellaneous databases

PROiQ4QQT4.

Gene expression databases

BgeeiENSRNOG00000010922.
GenevisibleiQ4QQT4. RN.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR031090. PP2A_A_meta.
[Graphical view]
PANTHERiPTHR10648:SF9. PTHR10648:SF9. 1 hit.
PfamiPF02985. HEAT. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2AAB_RAT
AccessioniPrimary (citable) accession number: Q4QQT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.