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Protein

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

Gene

Ppp2r1b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1
R-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-180024 DARPP-32 events
R-RNO-195253 Degradation of beta-catenin by the destruction complex
R-RNO-196299 Beta-catenin phosphorylation cascade
R-RNO-198753 ERK/MAPK targets
R-RNO-202670 ERKs are inactivated
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-389513 CTLA4 inhibitory signaling
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-5673000 RAF activation
R-RNO-5675221 Negative regulation of MAPK pathway
R-RNO-6804757 Regulation of TP53 Degradation
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-68877 Mitotic Prometaphase
R-RNO-69231 Cyclin D associated events in G1
R-RNO-69273 Cyclin A/B1/B2 associated events during G2/M transition

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Alternative name(s):
PP2A subunit A isoform PR65-beta
PP2A subunit A isoform R1-beta
Gene namesi
Name:Ppp2r1b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1304764 Ppp2r1b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714062 – 601Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoformAdd BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ4QQT4
PRIDEiQ4QQT4

PTM databases

iPTMnetiQ4QQT4
PhosphoSitePlusiQ4QQT4

Expressioni

Gene expression databases

BgeeiENSRNOG00000010922
GenevisibleiQ4QQT4 RN

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9 (By similarity). Interacts with SGO1 (By similarity). Interacts with RAF1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ4QQT4, 1 interactor
MINTiQ4QQT4
STRINGi10116.ENSRNOP00000059428

Structurei

3D structure databases

ProteinModelPortaliQ4QQT4
SMRiQ4QQT4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 58HEAT 1Add BLAST39
Repeati59 – 96HEAT 2Add BLAST38
Repeati97 – 135HEAT 3Add BLAST39
Repeati136 – 173HEAT 4Add BLAST38
Repeati174 – 212HEAT 5Add BLAST39
Repeati213 – 251HEAT 6Add BLAST39
Repeati252 – 290HEAT 7Add BLAST39
Repeati291 – 333HEAT 8Add BLAST43
Repeati334 – 372HEAT 9Add BLAST39
Repeati373 – 411HEAT 10Add BLAST39
Repeati412 – 450HEAT 11Add BLAST39
Repeati451 – 489HEAT 12Add BLAST39
Repeati490 – 528HEAT 13Add BLAST39
Repeati529 – 567HEAT 14Add BLAST39
Repeati568 – 601HEAT 15Add BLAST34

Domaini

Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0211 Eukaryota
ENOG410XQVI LUCA
GeneTreeiENSGT00730000110944
HOGENOMiHOG000078539
HOVERGENiHBG000011
InParanoidiQ4QQT4
KOiK03456
OMAiIEDKSWR
OrthoDBiEOG091G045V

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000357 HEAT
IPR021133 HEAT_type_2
PfamiView protein in Pfam
PF02985 HEAT, 3 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50077 HEAT_REPEAT, 12 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q4QQT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGAAGPGTV PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI
60 70 80 90 100
ALALGVERTR TELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC
110 120 130 140 150
LLPPLESLAT VEETVVRDKA VESLRQISQE HTPVALEAHF VPLVKRLASG
160 170 180 190 200
DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ HFRSLCSDDT PMVRRAAASK
210 220 230 240 250
LGEFAKVLEL DSVKTEIVPL FTNLASDEQD SVRLLAVEAC VSIAQLLSQD
260 270 280 290 300
DLEALVMPTL RQAAEDKSWR VRYMVADKFS ELQKAVGPKI ALSDLIPAFQ
310 320 330 340 350
SLLRDCEAEV RAAAAHKVRE LCENLPTEGR ETVIMNQILP YIKELVSDTN
360 370 380 390 400
QHVKSALASV IMGLSTVLGK ENTIEHLLPL FLAQLKDECP EVRLNIISNL
410 420 430 440 450
DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF
460 470 480 490 500
FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV
510 520 530 540 550
MANDPNYLHR MTTLFCINAL SEACGKEITT KQMLPIVLKM AGDQVANVRF
560 570 580 590 600
NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL

A
Length:601
Mass (Da):66,006
Last modified:July 19, 2005 - v1
Checksum:iDA2A0BA19FC5A46D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098007 mRNA Translation: AAH98007.1
RefSeqiNP_001020589.1, NM_001025418.1
UniGeneiRn.163017

Genome annotation databases

EnsembliENSRNOT00000064290; ENSRNOP00000059428; ENSRNOG00000010922
GeneIDi315648
KEGGirno:315648
UCSCiRGD:1304764 rat

Similar proteinsi

Entry informationi

Entry namei2AAB_RAT
AccessioniPrimary (citable) accession number: Q4QQT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: July 19, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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