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Protein

Interleukin-1 receptor-associated kinase-like 2

Gene

Irak2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371ATPPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi216 – 2249ATPPROSITE-ProRule annotation
Nucleotide bindingi337 – 3404ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-209543. p75NTR recruits signalling complexes.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-RNO-937042. IRAK2 mediated activation of TAK1 complex.
R-RNO-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-RNO-975155. MyD88 dependent cascade initiated on endosome.
R-RNO-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase-like 2
Short name:
IRAK-2
Gene namesi
Name:Irak2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1309584. Irak2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 624624Interleukin-1 receptor-associated kinase-like 2PRO_0000277562Add
BLAST

Proteomic databases

PaxDbiQ4QQS0.
PRIDEiQ4QQS0.

PTM databases

iPTMnetiQ4QQS0.
PhosphoSiteiQ4QQS0.

Expressioni

Gene expression databases

GenevisibleiQ4QQS0. RN.

Interactioni

Subunit structurei

Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034508.

Structurei

3D structure databases

ProteinModelPortaliQ4QQS0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 9482DeathAdd
BLAST
Domaini210 – 475266Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 death domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063073.
HOGENOMiHOG000113102.
HOVERGENiHBG052145.
InParanoidiQ4QQS0.
KOiK04731.
OMAiLSEWDWM.
OrthoDBiEOG747PHP.
PhylomeDBiQ4QQS0.
TreeFamiTF328924.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033611. IRAK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24419:SF2. PTHR24419:SF2. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQS0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACYIYQLPS WVLDDLCRNI DTLSEWDWMQ FASYVITDLT QLRKIKSMER
60 70 80 90 100
VQGVSITREL LWWWSMRQAT VQQLVDLLCH LELYRAAQIV LSWKPAPDSL
110 120 130 140 150
SPLSAFPEAV KPGPVATSGR NLKDDQKKGQ PVKPCSFLSS GTTMAGAQQQ
160 170 180 190 200
ASCQRPCEED APCSLKTDVP DSLQSKYCST SIPKQEKLLN LPGDRLFWSE
210 220 230 240 250
ADIVQATEDF DQSHRISEGT FADIYRGQRN GVAFAFKRLR EVTGSSPGSM
260 270 280 290 300
DRFLQAEMQL CLRCCHPNIL PLLGFCTGRQ FHSLIYPYMA NGSLQDRLWA
310 320 330 340 350
QGDSDMLSWP QRASICSGLL LAVEHLHSLD IIHSNVKSAN VLLDQHLNPK
360 370 380 390 400
LAHPVAHPCP TNKKTKYTVM KTHLFQASAA YLPENFIRVG QLTKQVDIFS
410 420 430 440 450
CGIVLAEVLT GIPAMDKDRS PVYLKDLLLS EIPSNTSSVH SRKTSMGKVV
460 470 480 490 500
VKEICQKHLE RKAGLLPEAC AETWATAVSV CLRRREASLE EARVSMAGVE
510 520 530 540 550
EQLRGQLSLP WSRVSEDTGS SSNTPEETDD VDNSSLSVPS SVMVVSCARV
560 570 580 590 600
SSPPPSMGNG TAQPSTSGRQ EADSSSEACA GPQPPQEATE TSWKIEINEA
610 620
KRRLMENILL YKEEKLDSVE LFGP
Length:624
Mass (Da):69,237
Last modified:July 19, 2005 - v1
Checksum:iEF8995F30AB4FDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098060 mRNA. Translation: AAH98060.1.
RefSeqiNP_001020593.1. NM_001025422.1.
UniGeneiRn.17123.

Genome annotation databases

EnsembliENSRNOT00000029819; ENSRNOP00000034508; ENSRNOG00000021817.
GeneIDi362418.
KEGGirno:362418.
UCSCiRGD:1309584. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098060 mRNA. Translation: AAH98060.1.
RefSeqiNP_001020593.1. NM_001025422.1.
UniGeneiRn.17123.

3D structure databases

ProteinModelPortaliQ4QQS0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034508.

PTM databases

iPTMnetiQ4QQS0.
PhosphoSiteiQ4QQS0.

Proteomic databases

PaxDbiQ4QQS0.
PRIDEiQ4QQS0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000029819; ENSRNOP00000034508; ENSRNOG00000021817.
GeneIDi362418.
KEGGirno:362418.
UCSCiRGD:1309584. rat.

Organism-specific databases

CTDi3656.
RGDi1309584. Irak2.

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063073.
HOGENOMiHOG000113102.
HOVERGENiHBG052145.
InParanoidiQ4QQS0.
KOiK04731.
OMAiLSEWDWM.
OrthoDBiEOG747PHP.
PhylomeDBiQ4QQS0.
TreeFamiTF328924.

Enzyme and pathway databases

ReactomeiR-RNO-168638. NOD1/2 Signaling Pathway.
R-RNO-209543. p75NTR recruits signalling complexes.
R-RNO-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-RNO-446652. Interleukin-1 signaling.
R-RNO-450302. activated TAK1 mediates p38 MAPK activation.
R-RNO-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-RNO-937042. IRAK2 mediated activation of TAK1 complex.
R-RNO-975138. TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
R-RNO-975155. MyD88 dependent cascade initiated on endosome.
R-RNO-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.

Miscellaneous databases

PROiQ4QQS0.

Gene expression databases

GenevisibleiQ4QQS0. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR033611. IRAK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PANTHERiPTHR24419:SF2. PTHR24419:SF2. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiIRAK2_RAT
AccessioniPrimary (citable) accession number: Q4QQS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 19, 2005
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Asn-335 is present instead of the conserved Asp which is expected to be an active site residue.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.