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Q4QQQ7

- PO3F1_XENTR

UniProt

Q4QQQ7 - PO3F1_XENTR

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Protein

POU domain, class 3, transcription factor 1

Gene

pou3f1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in neuronal differentiation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi286 – 34560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. nervous system development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1Imported
Gene namesi
Name:pou3f1Imported
ORF Names:TTpA009b07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-853354. pou3f1.

Subcellular locationi

Nucleus By similarityPROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375POU domain, class 3, transcription factor 1PRO_0000389615Add
BLAST

Expressioni

Gene expression databases

BgeeiQ4QQQ7.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000025161.

Structurei

3D structure databases

ProteinModelPortaliQ4QQQ7.
SMRiQ4QQQ7. Positions 200-346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 26875POU-specificPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 19192His-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-3 subfamily.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
Contains 1 POU-specific domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiQ4QQQ7.
KOiK09365.
OMAiKLMHHEW.
OrthoDBiEOG7DJSMG.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q4QQQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT
60 70 80 90 100
NAGHPMSLTH HQWLPNPASD WGSGSHLGAQ AEHGKSGVQS SREDLSSSFH
110 120 130 140 150
HHRSHLVHQQ TPSSHAWAQS GGHHLPPMSP GSNSHQPLIY SQSSYTNLNG
160 170 180 190 200
MLGPQASSLH HSMRDPLHDD PGVLDTHVES PPQHLSHHQD HSDEDAPSSD
210 220 230 240 250
DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF
260 270 280 290 300
KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA
310 320 330 340 350
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP
360 370
HPPMEDVYSQ AETPPLHHTL QTSVQ
Length:375
Mass (Da):41,846
Last modified:July 19, 2005 - v1
Checksum:i3943AF27D39A7C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760792 mRNA. Translation: CAJ82966.1.
BC098088 mRNA. Translation: AAH98088.1.
RefSeqiNP_001016504.1. NM_001016504.2.
UniGeneiStr.25752.

Genome annotation databases

EnsembliENSXETT00000025161; ENSXETP00000025161; ENSXETG00000011510.
GeneIDi549258.
KEGGixtr:549258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760792 mRNA. Translation: CAJ82966.1 .
BC098088 mRNA. Translation: AAH98088.1 .
RefSeqi NP_001016504.1. NM_001016504.2.
UniGenei Str.25752.

3D structure databases

ProteinModelPortali Q4QQQ7.
SMRi Q4QQQ7. Positions 200-346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000025161.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000025161 ; ENSXETP00000025161 ; ENSXETG00000011510 .
GeneIDi 549258.
KEGGi xtr:549258.

Organism-specific databases

CTDi 5453.
Xenbasei XB-GENE-853354. pou3f1.

Phylogenomic databases

eggNOGi NOG261729.
GeneTreei ENSGT00760000118935.
HOGENOMi HOG000116303.
HOVERGENi HBG053120.
InParanoidi Q4QQQ7.
KOi K09365.
OMAi KLMHHEW.
OrthoDBi EOG7DJSMG.
TreeFami TF316413.

Gene expression databases

Bgeei Q4QQQ7.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: TadpoleImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: F6Imported.

Entry informationi

Entry nameiPO3F1_XENTR
AccessioniPrimary (citable) accession number: Q4QQQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 19, 2005
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3