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Protein

POU domain, class 3, transcription factor 1

Gene

pou3f1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in neuronal differentiation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi286 – 345HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1Imported
Gene namesi
Name:pou3f1Imported
ORF Names:TTpA009b07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-853354. pou3f1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003896151 – 375POU domain, class 3, transcription factor 1Add BLAST375

Proteomic databases

PaxDbiQ4QQQ7.

Expressioni

Gene expression databases

BgeeiENSXETG00000011510.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000025161.

Structurei

3D structure databases

ProteinModelPortaliQ4QQQ7.
SMRiQ4QQQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 268POU-specificPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 191His-richSequence analysisAdd BLAST92

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-3 subfamily.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802. Eukaryota.
ENOG410XQ7X. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiQ4QQQ7.
KOiK09365.
OMAiMEDVYSQ.
OrthoDBiEOG091G0U0S.
TreeFamiTF316413.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom_sf.
IPR013847. POU.
IPR000327. POU_dom.
IPR016362. TF_POU_3.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4QQQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT
60 70 80 90 100
NAGHPMSLTH HQWLPNPASD WGSGSHLGAQ AEHGKSGVQS SREDLSSSFH
110 120 130 140 150
HHRSHLVHQQ TPSSHAWAQS GGHHLPPMSP GSNSHQPLIY SQSSYTNLNG
160 170 180 190 200
MLGPQASSLH HSMRDPLHDD PGVLDTHVES PPQHLSHHQD HSDEDAPSSD
210 220 230 240 250
DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI CRFEALQLSF
260 270 280 290 300
KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA
310 320 330 340 350
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP
360 370
HPPMEDVYSQ AETPPLHHTL QTSVQ
Length:375
Mass (Da):41,846
Last modified:July 19, 2005 - v1
Checksum:i3943AF27D39A7C59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR760792 mRNA. Translation: CAJ82966.1.
BC098088 mRNA. Translation: AAH98088.1.
RefSeqiNP_001016504.1. NM_001016504.2.
UniGeneiStr.25752.

Genome annotation databases

EnsembliENSXETT00000025161; ENSXETP00000025161; ENSXETG00000011510.
GeneIDi549258.
KEGGixtr:549258.

Similar proteinsi

Entry informationi

Entry nameiPO3F1_XENTR
AccessioniPrimary (citable) accession number: Q4QQQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 19, 2005
Last modified: November 22, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families