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Q4QQQ7 (PO3F1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 1
Gene names
Name:pou3f1
ORF Names:TTpA009b07.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in neuronal differentiation By similarity. UniProtKB P31363

Subcellular location

Nucleus By similarity UniProtKB P31361.

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processNeurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnervous system development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375POU domain, class 3, transcription factor 1
PRO_0000389615

Regions

Domain194 – 26875POU-specific
DNA binding286 – 34560Homeobox
Compositional bias100 – 19192His-rich

Sequences

Sequence LengthMass (Da)Tools
Q4QQQ7 [UniParc].

Last modified July 19, 2005. Version 1.
Checksum: 3943AF27D39A7C59

FASTA37541,846
        10         20         30         40         50         60 
MAATAQYLPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HQEYLQGLAT NAGHPMSLTH 

        70         80         90        100        110        120 
HQWLPNPASD WGSGSHLGAQ AEHGKSGVQS SREDLSSSFH HHRSHLVHQQ TPSSHAWAQS 

       130        140        150        160        170        180 
GGHHLPPMSP GSNSHQPLIY SQSSYTNLNG MLGPQASSLH HSMRDPLHDD PGVLDTHVES 

       190        200        210        220        230        240 
PPQHLSHHQD HSDEDAPSSD DLEQFAKQFK QRRIKLGFTQ ADVGLALGTL YGNVFSQTTI 

       250        260        270        280        290        300 
CRFEALQLSF KNMCKLKPLL NKWLEETDST TGSPTNLDKI AAQGRKRKKR TSIEVGVKGA 

       310        320        330        340        350        360 
LENHFLKCPK PSAHEITSLA DSLQLEKEVV RVWFCNRRQK EKRMTPAGVP HPPMEDVYSQ 

       370 
AETPPLHHTL QTSVQ 

« Hide

References

[1]Sanger Xenopus tropicalis EST/cDNA project
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Tadpole.
[2]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: F6.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR760792 mRNA. Translation: CAJ82966.1.
BC098088 mRNA. Translation: AAH98088.1.
RefSeqNP_001016504.1. NM_001016504.2.
UniGeneStr.25752.

3D structure databases

ProteinModelPortalQ4QQQ7.
SMRQ4QQQ7. Positions 200-346.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000025161.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000025161; ENSXETP00000025161; ENSXETG00000011510.
GeneID549258.
KEGGxtr:549258.

Organism-specific databases

CTD5453.
XenbaseXB-GENE-853354. pou3f1.

Phylogenomic databases

eggNOGNOG261729.
GeneTreeENSGT00730000110809.
HOGENOMHOG000116303.
HOVERGENHBG053120.
InParanoidQ4QQQ7.
KOK09365.
OMAKLMHHEW.
OrthoDBEOG7DJSMG.
TreeFamTF316413.

Gene expression databases

BgeeQ4QQQ7.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePO3F1_XENTR
AccessionPrimary (citable) accession number: Q4QQQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: July 19, 2005
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families