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Protein
Submitted name:

SLC8A1 protein

Gene

SLC8A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
SLC8A1 proteinImported
Gene namesi
Name:SLC8A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei209 – 23325HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei318 – 33821HelicalSequence analysisAdd
BLAST
Transmembranei354 – 37219HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA314.

PTM / Processingi

Proteomic databases

PaxDbiQ4QQH3.

Expressioni

Gene expression databases

BgeeiQ4QQH3.
GenevisibleiQ4QQH3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332931.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 3736Calx-betaInterPro annotationAdd
BLAST
Domaini212 – 374163Na_Ca_exInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sodium/potassium/calcium exchanger family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
HOVERGENiHBG006441.
KOiK05849.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 1 hit.
PF01699. Na_Ca_ex. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.

Sequencei

Sequence statusi: Fragment.

Q4QQH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DTCGELEFQN DEIVKTISVK VIDDEEYEKN KTFFLEIGEP RLVEMSEKKA
60 70 80 90 100
LLLNELGGFT ITGKYLFGQP VFRKVHAREH PILSTVITIA DEYDDKQPLT
110 120 130 140 150
SKEEEERRIA EMGRPILGEH TKLEVIIEES YEFKSTVDKL IKKTNLALVV
160 170 180 190 200
GTNSWREQFI EAITVSAGED DDDDECGEEK LPSCFDYVMH FLTVFWKVLF
210 220 230 240 250
AFVPPTEYWN GWACFIVSIL MIGLLTAFIG DLASHFGCTI GLKDSVTAVV
260 270 280 290 300
FVALGTSVPD TFASKVAATQ DQYADASIGN VTGSNAVNVF LGIGVAWSIA
310 320 330 340 350
AIYHAANGEQ FKVSPGTLAF SVTLFTIFAF INVGVLLYRR RPEIGGELGG
360 370 380
PRTAKLLTSC LFVLLWLLYI FFSSLEAYCH IKGF
Length:384
Mass (Da):42,734
Last modified:July 19, 2005 - v1
Checksum:i759F0B6C87D899AF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098285 mRNA. Translation: AAH98285.1.
RefSeqiNP_001106271.1. NM_001112800.1.
UniGeneiHs.31961.
Hs.468274.
Hs.744988.

Genome annotation databases

GeneIDi6546.
KEGGihsa:6546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC098285 mRNA. Translation: AAH98285.1.
RefSeqiNP_001106271.1. NM_001112800.1.
UniGeneiHs.31961.
Hs.468274.
Hs.744988.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332931.

Proteomic databases

PaxDbiQ4QQH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6546.
KEGGihsa:6546.

Organism-specific databases

CTDi6546.
PharmGKBiPA314.

Phylogenomic databases

eggNOGiKOG1306. Eukaryota.
ENOG410XPJP. LUCA.
HOVERGENiHBG006441.
KOiK05849.

Miscellaneous databases

ChiTaRSiSLC8A1. human.
GenomeRNAii6546.
NextBioi25469.

Gene expression databases

BgeeiQ4QQH3.
GenevisibleiQ4QQH3. HS.

Family and domain databases

InterProiIPR003644. Calx_beta.
IPR004836. Na_Ca_Ex.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF03160. Calx-beta. 1 hit.
PF01699. Na_Ca_ex. 1 hit.
[Graphical view]
PRINTSiPR01259. NACAEXCHNGR.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiQ4QQH3_HUMAN
AccessioniPrimary (citable) accession number: Q4QQH3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2005
Last sequence update: July 19, 2005
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.