Q4QPJ6 (UXAC_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uronate isomerase
EC=5.3.1.12

Alternative name(s):
Glucuronate isomerase
Uronic isomerase

Gene names

Name:	uxaC
Ordered Locus Names:	NTHI0056

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	467 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucuronate = D-fructuronate. HAMAP MF_00675 D-galacturonate = D-tagaturonate. HAMAP MF_00675
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00675
Sequence similarities	Belongs to the uronate isomerase family.

Ontologies

Keywords
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	glucuronate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 467	467	Uronate isomerase HAMAP MF_00675		PRO_1000044768

Sequences

	Sequence		Length	Mass (Da)
	Q4QPJ6 [UniParc]. Last modified August 30, 2005. Version 1. Checksum: 4CC03C3DDED0B851	FASTA	467	54,153
	10 20 30 40 50 60 MKQFMDENFL LSTDTAKILY HDYAKNKPIF DYHCHLNPRE VAENRQFNDL AEIWLEGDHY 70 80 90 100 110 120 KWRALRTAGV PEELITGKAT NYQKYLAWAK TVPLCIGNPI YHWTHLELRR PFGITNMLFN 130 140 150 160 170 180 PQNAEKIWHQ CNEMLQQPEF SARGIMQKMN VKLVGTTDDP IDSLQYHQAI KNDESFDIDV 190 200 210 220 230 240 VPSWRPDKVF KIELPQFNDY LVQLSEIADV DIYTFADLKK ALLKRLEYFD AQGCKSADHG 250 260 270 280 290 300 MEIVRFSAIP DESVLNSILQ KRLQNQPLLE EEVAQFSTAI LVWLASEYCK RHWVMQMHIG 310 320 330 340 350 360 AIRNNNSRMF ALLGADSGFD SIGDRTYAYP LSRLLDAMDK ENQLPKTILY CLNPRDNEMI 370 380 390 400 410 420 ASMIGNFQGD GIAGKIQFGS GWWFNDQKDG MERQLQQLSQ LGLLSQFVGM LTDSRSFLSY 430 440 450 460 TRHEYFRRIL CEMIGGWVEK GEAPNDISLL GKMIEDICFN NAKNYFK

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87051.1.
RefSeq	YP_247711.1. NC_007146.2.
3D structure databases
ProteinModelPortal	Q4QPJ6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QPJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3431056.
GenomeReviews	Gene locus NTHI0056 in contig CP000057_GR.
KEGG	hit:NTHI0056.
PATRIC	20180286. VBIHaeInf100748_0048.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1904.
HOGENOM	HBG297087.
OMA	AWAKTVP.
PhylomeDB	Q4QPJ6.
ProtClustDB	PRK02925.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0056-MONOMER.
Family and domain databases
HAMAP	MF_00675. UxaC. [Tree]
InterPro	IPR003766. Uronate_isomerase. IPR023177. Uronate_isomerase_dom2. [Graphical view]
Gene3D	G3DSA:1.10.2020.10. Uronate_isomerase_dom2. 1 hit.
KO	K01812.
Pfam	PF02614. UxaC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAC_HAEI8

Accession

Primary (citable) accession number: Q4QPJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 30, 2005
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program