Q4QPI9 (UXUA_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	NTHI0065

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 394	394	Mannonate dehydratase HAMAP MF_00106		PRO_0000231053

Sequences

	Sequence		Length	Mass (Da)
	Q4QPI9 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 944B1515B026BF41	FASTA	394	45,307
	10 20 30 40 50 60 MEQAWRWYGP KDPVSLSDIR QAGATGIVTA LHHIPNGEVW SIEEIKKRKT EIENAGLSWS 70 80 90 100 110 120 VVESVPVHEE IKTQTGNYQK WINNYKQTLR NLAQCGIDTV CYNFMPVLDW TRTDLAYELP 130 140 150 160 170 180 DGSKALRFDH IAFAAFELHI LKRPDAEKAY NQEEQVAART YYDKMSEQDI TQLTRNIIAG 190 200 210 220 230 240 LPGAEEGYTL DEFQTQLDRY KDISPEKFRT HLAYFLNEIV PVAQEVGIKM AIHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWFVET QPLPANGFTM CTGSYGVRSD NDLVKMTEQF ADRIYFAHLR 310 320 330 340 350 360 STQREDNPLT FHEAAHLEGD VDMFNVVKAL LNEEYRRLNQ GETRLIPMRP DHGHQMLDDL 370 380 390 RKKTNPGYSA IGRLKGLAEF RGLEMALKKV YFNK

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87058.1.
RefSeq	YP_247718.1. NC_007146.2.
3D structure databases
ProteinModelPortal	Q4QPI9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QPI9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3431064.
GenomeReviews	Gene locus NTHI0065 in contig CP000057_GR.
KEGG	hit:NTHI0065.
PATRIC	20180304. VBIHaeInf100748_0057.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
PhylomeDB	Q4QPI9.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0065-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_HAEI8

Accession

Primary (citable) accession number: Q4QPI9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program