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Protein

UvrABC system protein C

Gene

uvrC

Organism
Haemophilus influenzae (strain 86-028NP)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nuclease
Biological processDNA damage, DNA excision, DNA repair, SOS response

Enzyme and pathway databases

BioCyciHINF281310:GJ89-59-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein C
Short name:
Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene namesi
Name:uvrC
Ordered Locus Names:NTHI0067
OrganismiHaemophilus influenzae (strain 86-028NP)
Taxonomic identifieri281310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000002525 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002274351 – 609UvrABC system protein CAdd BLAST609

Interactioni

Subunit structurei

Interacts with UvrB in an incision complex.

Structurei

3D structure databases

ProteinModelPortaliQ4QPI7.
SMRiQ4QPI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 91GIY-YIGAdd BLAST79
Domaini201 – 236UVRAdd BLAST36

Sequence similaritiesi

Belongs to the UvrC family.

Phylogenomic databases

HOGENOMiHOG000279961.
KOiK03703.
OMAiLFPIRQC.
OrthoDBiPOG091H01BS.

Family and domain databases

Gene3Di3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPiMF_00203. UvrC. 1 hit.
InterProiView protein in InterPro
IPR000305. GIY-YIG_endonuc.
IPR035901. GIY-YIG_endonuc_sf.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
PfamiView protein in Pfam
PF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
SMARTiView protein in SMART
SM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsiTIGR00194. uvrC. 1 hit.
PROSITEiView protein in PROSITE
PS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q4QPI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDAKKFLAD VSHEPGVYRM YDDKDQVIYV GKAKDLKKRL SSYFRKNLSS
60 70 80 90 100
KKTEALVASI HHIDTMLTSS ETEALLLEHN FIKLYQPRYN VLLRDDKSYP
110 120 130 140 150
FILLTKERHP RITSYRGSKK FAGEYFGPYP HAGAVRETLS LLQKLFPVRQ
160 170 180 190 200
CENSVYSNRS RPCLQYQIGR CSAPCVQGYV SDEEYNQQVE LARLFLQGKD
210 220 230 240 250
QQVLDYLIGK MEQASRNLDF EQAARYRDQI QAVRSVIEKQ FVSNERLDDM
260 270 280 290 300
DIMSIAYQHG LACVQVMFIR QGKVLGNRSY FPKVPANTDL SELTETFVGQ
310 320 330 340 350
FYLQGHQGRS IPNSIIVDRQ LAEKSELEQL LTEQAGRKVT IQESVKGDKS
360 370 380 390 400
KYLQLAQVNA KAALNVQLKQ SSRMSERYQA LCDLLNLPEI KRMECFDISH
410 420 430 440 450
TMGNQTVASC VVFNQEGPLK SDYRRFNIEG ITGGDDYAAM EQALQKRYER
460 470 480 490 500
DLEEDKIPDI IFIDGGKGQL NRALNVFQHL QVKWDKNRPH LIGVAKGVDR
510 520 530 540 550
RAGQEVLIIS KQDREIHLPD DSLALHLIQH IRDESHNHAI SGHRKKRQKA
560 570 580 590 600
FTQSGLETIE GVGAKRRQAL LKYLGGLQGV KKATLDEIAS VPGISLKLAE

TIFETLKND
Length:609
Mass (Da):69,526
Last modified:July 19, 2005 - v1
Checksum:iED9C9E82BA2C728C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000057 Genomic DNA. Translation: AAX87060.1.
RefSeqiWP_011271801.1. NC_007146.2.

Genome annotation databases

EnsemblBacteriaiAAX87060; AAX87060; NTHI0067.
KEGGihit:NTHI0067.

Similar proteinsi

Entry informationi

Entry nameiUVRC_HAEI8
AccessioniPrimary (citable) accession number: Q4QPI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: July 19, 2005
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families