Q4QPH7 (MUTL_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	NTHI0080

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	629 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 629	629	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_1000010020

Sequences

	Sequence		Length	Mass (Da)
	Q4QPH7 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: D526E4ED250737F5	FASTA	629	71,654
	10 20 30 40 50 60 MPIKILSPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAN KIQIDIENGG ANLIRIRDNG 70 80 90 100 110 120 CGIPKEELSL ALARHATSKI ADLDDLEAIL SLGFRGEALA SISSVSRLTL TSRTEEQTEA 130 140 150 160 170 180 WQVYAQGRDM ETTIKPASHP VGTTVEVANL FFNTPARRKF LRTDKTEFAH IDEVIRRIAL 190 200 210 220 230 240 TKFNTAFTLT HNGKIIRQYR PAEAINQQLK RVAAICGDDF VKNALRIDWK HDDLHLSGWV 250 260 270 280 290 300 ATPNFSRTQN DLSYCYINGR MVRDKVISHA IRQAYAQYLP TDAYPAFVLF IDLNPHDVDV 310 320 330 340 350 360 NVHPTKHEVR FHQQRLIHDF IYEGISYALN NQEQLNWHTD QSAVENHEEN TVREPQPNYS 370 380 390 400 410 420 IRPNRAAAGQ NSFAPKYYEK PQQNQPHFSN TPVLPNHVST GYRDYRSDAP SKTEQRLYAE 430 440 450 460 470 480 LLRTLPPTAQ KDISDTAQQN ISDTAKIIST EIIECSSHLR TLSLIENRAL LLQQNQDFFL 490 500 510 520 530 540 LSLEKLQRLQ WQLALQQIQI EQQPLLIPIV FRLTEAQFQA WQQYSDNFKK IGFEFIENQA 550 560 570 580 590 600 QLRLTLNKVP NVLRTQNLQK CLMAMLTRDE NSSPFLTALC AQLECKTFDA LADALNLLSD 610 620 TERLLTQTNR TAFTQLLKPV NWQPLLDEI

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87070.1.
RefSeq	YP_247730.1. NC_007146.2.
3D structure databases
HSSP	HSSP built from PDB template 1BKN based on UniProtKB P23367.
ProteinModelPortal	Q4QPH7.
SMR	Q4QPH7. Positions 1-325.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QPH7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3431095.
GenomeReviews	Gene locus NTHI0080 in contig CP000057_GR.
KEGG	hit:NTHI0080.
PATRIC	20180330. VBIHaeInf100748_0070.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0323.
HOGENOM	HBG520262.
OMA	EVANLFF.
PhylomeDB	Q4QPH7.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0080-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_HAEI8

Accession

Primary (citable) accession number: Q4QPH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program