ID   URK_HAEI8               Reviewed;         213 AA.
AC   Q4QP55;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Uridine kinase;
DE            EC=2.7.1.48;
DE   AltName: Full=Uridine monophosphokinase;
DE   AltName: Full=Cytidine monophosphokinase;
GN   Name=udk; OrderedLocusNames=NTHI0218;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- CATALYTIC ACTIVITY: ATP + uridine = ADP + UMP.
CC   -!- CATALYTIC ACTIVITY: ATP + cytidine = ADP + CMP.
CC   -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage
CC       pathway; CTP from cytidine: step 1/3.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage
CC       pathway; UMP from uridine: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the uridine kinase family.
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DR   EMBL; CP000057; AAX87192.1; -; Genomic_DNA.
DR   RefSeq; YP_247852.1; -.
DR   GeneID; 3429556; -.
DR   GenomeReviews; CP000057_GR; NTHI0218.
DR   KEGG; hit:NTHI0218; -.
DR   HOGENOM; Q4QP55; -.
DR   OMA; Q4QP55; NQFIEPT.
DR   BioCyc; HINF281310:NTHI0218-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0016773; F:phosphotransferase activity, alcohol group ...; IEA:InterPro.
DR   GO; GO:0004849; F:uridine kinase activity; IEA:HAMAP.
DR   GO; GO:0008655; P:pyrimidine salvage; IEA:HAMAP.
DR   HAMAP; MF_00551; -; 1.
DR   InterPro; IPR006083; PRK_URK.
DR   InterPro; IPR000764; Uridine_kinase.
DR   PANTHER; PTHR10285:SF6; Uridine_kin; 1.
DR   Pfam; PF00485; PRK; 1.
DR   PRINTS; PR00988; URIDINKINASE.
DR   TIGRFAMs; TIGR00235; udk; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding;
KW   Transferase.
FT   CHAIN         1    213       Uridine kinase.
FT                                /FTId=PRO_1000017877.
FT   NP_BIND      13     20       ATP (Potential).
SQ   SEQUENCE   213 AA;  24284 MW;  483B844ADA41E4D9 CRC64;
     MSNPSCIIIA ITGASASGKS SIASTVHKEL CNELGCQEIG IITEDSYYKD QSHLEMTERV
     KTNYDHPNSM DRDLLIQHLK NLKNGSAVDV PVYSYVEHTR TNETTHFTPK RIVILEGILL
     LTDERVRQLA DISVFVDTPL DICFIRRLQR DMEERGRSLQ SVIDQYRATV RPMFLQFIEP
     SKQYADIVIP RGGKNRIAIN MLKAQILHLL NQK
//