Reviewed, UniProtKB/Swiss-Prot Q4QP55 (URK_HAEI8)

Names and origin

Protein names

Recommended name:
    Uridine kinase
    EC=2.7.1.48
Alternative name(s):
    Uridine monophosphokinase
    Cytidine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	NTHI0218

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	213 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP MF_00551 ATP + cytidine = ADP + CMP. HAMAP MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine salvage Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 213	213	Uridine kinase HAMAP MF_00551		PRO_1000017877
Regions
	Nucleotide binding	13 – 20	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q4QP55-1 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: 483B844ADA41E4D9	FASTA	213	24,284
	10 20 30 40 50 60 MSNPSCIIIA ITGASASGKS SIASTVHKEL CNELGCQEIG IITEDSYYKD QSHLEMTERV 70 80 90 100 110 120 KTNYDHPNSM DRDLLIQHLK NLKNGSAVDV PVYSYVEHTR TNETTHFTPK RIVILEGILL 130 140 150 160 170 180 LTDERVRQLA DISVFVDTPL DICFIRRLQR DMEERGRSLQ SVIDQYRATV RPMFLQFIEP 190 200 210 SKQYADIVIP RGGKNRIAIN MLKAQILHLL NQK

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000057 Genomic DNA. Translation: AAX87192.1.
RefSeq	YP_247852.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3429556.
GenomeReviews	Gene locus NTHI0218 in contig CP000057_GR.
KEGG	hit:NTHI0218.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q4QP55.
OMA	Q4QP55. NQFIEPT.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0218-MON.
Family and domain databases
HAMAP	MF_00551. [Tree]
InterPro	IPR006083. PRK_URK. IPR000764. Uridine_kinase. [Graphical view]
PANTHER	PTHR10285:SF6. Uridine_kin. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_HAEI8

Accession

Primary (citable) accession number: Q4QP55

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)