ID   NANK_HAEI8              Reviewed;         300 AA.
AC   Q4QP43;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=N-acetylmannosamine kinase;
DE            EC=2.7.1.60;
DE   AltName: Full=N-acetyl-D-mannosamine kinase;
DE   AltName: Full=ManNAc kinase;
GN   Name=nanK; OrderedLocusNames=NTHI0230;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetylmannosamine
CC       (ManNAc) to ManNAc-6-P (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-
CC       mannosamine 6-phosphate.
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminic acid
CC       degradation; D-fructose 6-phosphate from N-acetylneuraminic acid:
CC       step 2/5.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NanK subfamily.
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DR   EMBL; CP000057; AAX87204.1; -; Genomic_DNA.
DR   RefSeq; YP_247864.1; -.
DR   GeneID; 3429570; -.
DR   GenomeReviews; CP000057_GR; NTHI0230.
DR   KEGG; hit:NTHI0230; -.
DR   HOGENOM; Q4QP43; -.
DR   OMA; Q4QP43; KNDEKAT.
DR   BioCyc; HINF281310:NTHI0230-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0009384; F:N-acylmannosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006051; P:N-acetylmannosamine metabolic process; IEA:HAMAP.
DR   HAMAP; MF_01234; -; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    300       N-acetylmannosamine kinase.
FT                                /FTId=PRO_0000301459.
FT   NP_BIND       5     12       ATP (Potential).
FT   NP_BIND     132    139       ATP (Potential).
FT   METAL       156    156       Zinc (By similarity).
FT   METAL       166    166       Zinc (By similarity).
FT   METAL       168    168       Zinc (By similarity).
FT   METAL       173    173       Zinc (By similarity).
SQ   SEQUENCE   300 AA;  31964 MW;  ECDD3F41A7A8DED2 CRC64;
     MRCLALDIGG TKIAAAIVKN GEIEQRQQIH TPRENVVEGM HQALGKLLAD YEGQFDYVAV
     ASTGIINNGI LSALNPKNLG GLAEFPLKAS IAKHTDKPIG LLNDAQAATY AEYQLQNFEQ
     VSNFVFITVS TGVGGGIVLN QILQTGSRGI AGHIGHTLAD PNGAICGCGR RGCVEAIASG
     RAIEAVSSQW EDPCDPKEVF ERFRKNDEKA TALVERSAKA IANLIADLVI SLDIQKIAIG
     GSVGLAEGYL SLVEKYLQDF PSIYCCEIET AKFGQDAGLI GAAYWVKDVL LDKPEGTIYG
//