Q4QP43 (NANK_HAEI8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetylmannosamine kinase
EC=2.7.1.60

Alternative name(s):
ManNAc kinase
N-acetyl-D-mannosamine kinase

Gene names

Name:	nanK
Ordered Locus Names:	NTHI0230

Organism

Haemophilus influenzae (strain 86-028NP) [Complete proteome] [HAMAP]

Taxonomic identifier

281310 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P By similarity. HAMAP MF_01234
Catalytic activity	ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate. HAMAP MF_01234
Pathway	Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 2/5. HAMAP MF_01234
Subunit structure	Homodimer By similarity. HAMAP MF_01234
Sequence similarities	Belongs to the ROK (nagC/xylR) family. NanK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	N-acetylneuraminate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW N-acylmannosamine kinase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 300	300	N-acetylmannosamine kinase HAMAP MF_01234		PRO_0000301459
Regions
	Nucleotide binding	5 – 12	8	ATP Potential
	Nucleotide binding	132 – 139	8	ATP Potential
Sites
	Metal binding	156	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity
	Metal binding	168	1	Zinc By similarity
	Metal binding	173	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q4QP43 [UniParc]. Last modified July 19, 2005. Version 1. Checksum: ECDD3F41A7A8DED2	FASTA	300	31,964
	10 20 30 40 50 60 MRCLALDIGG TKIAAAIVKN GEIEQRQQIH TPRENVVEGM HQALGKLLAD YEGQFDYVAV 70 80 90 100 110 120 ASTGIINNGI LSALNPKNLG GLAEFPLKAS IAKHTDKPIG LLNDAQAATY AEYQLQNFEQ 130 140 150 160 170 180 VSNFVFITVS TGVGGGIVLN QILQTGSRGI AGHIGHTLAD PNGAICGCGR RGCVEAIASG 190 200 210 220 230 240 RAIEAVSSQW EDPCDPKEVF ERFRKNDEKA TALVERSAKA IANLIADLVI SLDIQKIAIG 250 260 270 280 290 300 GSVGLAEGYL SLVEKYLQDF PSIYCCEIET AKFGQDAGLI GAAYWVKDVL LDKPEGTIYG

References

[1]

"Genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B., Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O., Munson R.S. Jr. J. Bacteriol. 187:4627-4636(2005) [PubMed: 15968074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 86-028NP.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000057 Genomic DNA. Translation: AAX87204.1.
RefSeq	YP_247864.1. NC_007146.2.
3D structure databases
HSSP	HSSP built from PDB template 2AA4 based on UniProtKB P45425.
ProteinModelPortal	Q4QP43.
ModBase	Search...
Protein-protein interaction databases
STRING	Q4QP43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3429570.
GenomeReviews	Gene locus NTHI0230 in contig CP000057_GR.
KEGG	hit:NTHI0230.
PATRIC	20180646. VBIHaeInf100748_0211.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1940.
HOGENOM	HBG730260.
OMA	KNDEKAT.
PhylomeDB	Q4QP43.
ProtClustDB	PRK05082.
Enzyme and pathway databases
BioCyc	HINF281310:NTHI0230-MONOMER.
Family and domain databases
HAMAP	MF_01234. ManNAc_kinase. [Tree]
InterPro	IPR023945. ManNAc_kinase_bac. IPR000600. ROK. [Graphical view]
KO	K00885.
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NANK_HAEI8

Accession

Primary (citable) accession number: Q4QP43

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2005
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program