ID   NAGK_HAEI8              Reviewed;         304 AA.
AC   Q4QP08;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=N-acetyl-D-glucosamine kinase;
DE            EC=2.7.1.59;
DE   AltName: Full=GlcNAc kinase;
GN   Name=nagK; OrderedLocusNames=NTHI0273;
OS   Haemophilus influenzae (strain 86-028NP).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=281310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15968074; DOI=10.1128/JB.187.13.4627-4636.2005;
RA   Harrison A., Dyer D.W., Gillaspy A., Ray W.C., Mungur R., Carson M.B.,
RA   Zhong H., Gipson J., Gipson M., Johnson L.S., Lewis L., Bakaletz L.O.,
RA   Munson R.S. Jr.;
RT   "Genomic sequence of an otitis media isolate of nontypeable
RT   Haemophilus influenzae: comparative study with H. influenzae serotype
RT   d, strain KW20.";
RL   J. Bacteriol. 187:4627-4636(2005).
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetyl-D-glucosamine
CC       (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-
CC       D-glucosamine 6-phosphate.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan recycling.
CC   -!- SIMILARITY: Belongs to the ROK (nagC/xylR) family. NagK subfamily.
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DR   EMBL; CP000057; AAX87239.1; -; Genomic_DNA.
DR   RefSeq; YP_247899.1; -.
DR   GeneID; 3429606; -.
DR   GenomeReviews; CP000057_GR; NTHI0273.
DR   KEGG; hit:NTHI0273; -.
DR   HOGENOM; Q4QP08; -.
DR   OMA; Q4QP08; HVERFME.
DR   BioCyc; HINF281310:NTHI0273-MON; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0045127; F:N-acetylglucosamine kinase activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006044; P:N-acetylglucosamine metabolic process; IEA:HAMAP.
DR   GO; GO:0009254; P:peptidoglycan turnover; IEA:HAMAP.
DR   HAMAP; MF_01271; -; 1.
DR   InterPro; IPR000600; ROK.
DR   Pfam; PF00480; ROK; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    304       N-acetyl-D-glucosamine kinase.
FT                                /FTId=PRO_0000270106.
FT   NP_BIND       4     11       ATP (Potential).
FT   NP_BIND     133    140       ATP (Potential).
FT   METAL       157    157       Zinc (By similarity).
FT   METAL       178    178       Zinc (By similarity).
FT   METAL       180    180       Zinc (By similarity).
FT   METAL       185    185       Zinc (By similarity).
SQ   SEQUENCE   304 AA;  33172 MW;  D77ABD8CEF6BF5F9 CRC64;
     MYYGLDIGGT KIELAVFNEE LEKLYSERVP TPKTDYEEWL NTIVDLVNRA DEKFGEVGTV
     GLGVPGFVNQ QTGLAEITNI RVADNKPILR DLSVRLGREV RAENDANCFA LSEAWDTENQ
     QYPTVLGLIL GTGFGGGFVL NGKVHSGQVG MAGELGHLQL NYHALKLLGW DNAPIYQCGC
     GNKACLDNYL SGRGFEMLYR DLKGETLSAR EIIDLFYQGN ESAVDFVNLF VELAAISIGN
     IITAFDPHMI VLGGGLSNFD YLYEALPKAL PPHLMRTAKV PPIKKAKHGD SGGVRGAAAL
     FLTK
//